Irene Farabella
banner
iosonoirene.bsky.social
Irene Farabella
@iosonoirene.bsky.social
💻 🧬 3D genome & RNA lovers Group Leader at Center for Human Technologies, Italian Institute of Technology | CDA @ArmeniseHarvard
Pinned
🧬 We’re hiring a Postdoc in Genomic Data Science @IITalk! Join us to explore 3D genome architecture and RNAs using imaging, genomics & ML 💻🔬🐠
💼 Up to €45k/year
✅ PhD + Python/ML skills
➕ Experience with omics, imaging, or modelling = plus
📍 Genoa 🌊☀️
📧 [email protected]
🔗 tinyurl.com/6z52jhr9
Postdoc in Genomic Data Science
Commitment & contract: Post Doc 1 year collaboration contract, renewable Location: Centre for Human Technologies – Genoa At the Italian Institute of Technology (IIT), we are committed to advancing h...
tinyurl.com
Reposted by Irene Farabella
4️⃣ Featuring the fourth of our showcase projects

Upgrading GROMACS to handle billion-atom systems and enhancing I/O performance and precision, making the first-ever whole-cell simulation possible ➡️ bioexcel.eu/uw67

#MolecularDynamics #GROMACS #ComputationalBiology
September 12, 2025 at 6:22 AM
Reposted by Irene Farabella
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
www.biorxiv.org/content/10.1...
Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
The nuclear periphery is a key site for heterochromatin organization in eukaryotic cells, where lamina-associated domains (LADs) promote transcriptional repression and genome stability. Despite their ...
www.biorxiv.org
August 14, 2025 at 7:01 PM
Reposted by Irene Farabella
Extensive differences observed in 3D genome structure between homologous heterozygous chromosomes revealed by Genome Architecture Mapping #GAM in the @apombo1.bsky.social lab ➡️ www.embopress.org/doi/full/10....
May 15, 2025 at 5:32 PM
Reposted by Irene Farabella
Glad to share our latest publication in Nature Genetics: Tracing the evolution of single-cell 3D genomes in Kras-driven cancers. In this work, we generated the first single-cell 3D genome atlases of any cancer using any technique. 1/12
August 19, 2025 at 4:53 PM
Reposted by Irene Farabella
What better way to launch our new account with the publication of @jmstein.bsky.social latest paper from the lab! 🧪 Check out the 🧵 below to learn more about tkPAINT and how we use it to image proteins, DNA, and RNA in the nucleus using DNA-PAINT.
(1/n) DNA-PAINT imaging inside the nucleus at single antibody resolution using TIRF? Ultrathin sectioning makes it happen!

Grateful to share my postdoctoral work introducing “tomographic & kinetically-enhanced DNA-PAINT” or in brief: tkPAINT. Out in @pnas.org!
doi.org/10.1073/pnas...
👇🧵
August 13, 2025 at 6:16 PM
Reposted by Irene Farabella
Our new preprint is out on bioRxiv! We show that restoring rigidity sensing via Tpm2.1 is not enough to trigger anoikis in cancer cells, thanks to compensatory AKT signaling and cell–cell adhesion.
With Anat, Nehal, and in memory of Mike Sheetz. www.biorxiv.org/content/10.1...
www.biorxiv.org
June 16, 2025 at 11:50 AM
Reposted by Irene Farabella
🌐 EMBL’s new initiative is set to transform life science research through full AI integration – from genomics to drug discovery.

💡 Funding from the Hector Foundation is dedicated to attracting interdisciplinary talent, boosting infrastructure, training, & innovation.

www.embl.org/news/connect...
August 1, 2025 at 7:15 AM
Reposted by Irene Farabella
To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
Reposted by Irene Farabella
Are you @ the late stages of your postdoc ? Want to pursue a PI career ?

Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...

Peer-networking / Career orientation and more !!!

Please distribute :) 🙂
June 12, 2025 at 12:58 PM
Reposted by Irene Farabella
New from the Dai and Li labs: Meta-learning-empowered reflective lattice light-sheet virtual structured illumination microscopy (Meta-rLLS-VSIM) offers near-isotropic resolution for fast and versatile super-resolution imaging of subcellular dynamics www.nature.com/articles/s41...
April 29, 2025 at 7:54 PM
Reposted by Irene Farabella
Out in Cell @cp-cell.bsky.social: Design principles of cell-state-specific enhancers in hematopoiesis
🧬🩸 screen of fully synthetic enhancers in blood progenitors
🤖 AI that creates new cell state specific enhancers
🔍 negative synergies between TFs lead to specificity!
www.cell.com/cell/fulltex...
🧵
Design principles of cell-state-specific enhancers in hematopoiesis
Screen of minimalistic enhancers in blood progenitor cells demonstrates widespread dual activator-repressor function of transcription factors (TFs) and enables the model-guided design of cell-state-sp...
www.cell.com
May 8, 2025 at 4:07 PM
Check this out! 👇🏻👇🏻
Amazing work on regulatory element evolution .. Bravo to all involved @arnausebe.bsky.social @mamartirenom.bsky.social but
expecially @ianakim.bsky.social … she is a star 👏🏻👏🏻
May 8, 2025 at 4:38 AM
Reposted by Irene Farabella
Perturb-tracing integrates CRISPR screening with barcode readout and chromatin tracing for loss-of-function screens, facilitating the study of chromatin folding regulators.

www.nature.com/articles/s41...
April 11, 2025 at 2:36 PM
Reposted by Irene Farabella
Read the News & Views highlighting this cool work here!

www.nature.com/articles/s41...
April 11, 2025 at 6:02 PM
Bravo to all !! Definitely in my reading list for the weekend !!
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 12, 2025 at 6:56 PM
Reposted by Irene Farabella
Excited to share our latest work on how cells fold their genomes, and build mitotic chromosomes! Out in Science today!

Lots of interesting results and proposals for those interested in loop extrusion, and chromosomes!

With @golobor.bsky.social, Leonid Mirny, Bill Earnshaw labs.

See thread below:
Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!!
www.science.org/doi/10.1126/...
A short clip describing the key results:
www.youtube.com/watch?v=pmvO...
Rules of Engagement
YouTube video by Johan Gibcus
www.youtube.com
April 11, 2025 at 4:06 PM
Reposted by Irene Farabella
Looking for a PhD in sunny Barcelona? ☀️🔬
Our team is hiring a PhD student for the @hologen.bsky.social
project!

📅 Deadline: *Apr 20*
⚠️ READ THE MOBILITY RULE FOR THIS POSITION
🔁 Please, spread the word

All the info here 👉 www.cnag.eu/jobs/phd-stu...

#PhDlife #Genomics #HoloGen #Barcelona
PhD Student - Structural Genomics Team (HoloGen Project) | CNAG, Centro Nacional de Análisis Genómico
MPORTANT MOBILITY RULE FOR THIS POSITION The MSCA mobility rule applies to this position: the applicant must not have resided or carried out their main activity (e.g., studies, work, research) in Spai...
www.cnag.eu
April 8, 2025 at 8:48 AM
Reposted by Irene Farabella
1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇
March 17, 2025 at 11:56 AM
Just apply! Amazing Lab ☺️
April 2, 2025 at 5:25 AM
Reposted by Irene Farabella
Looking for a PhD in sunny Barcelona? ☀️🔬
Our team is hiring a PhD student for the @hologen.bsky.social project!

📅 Deadline: Apr 20
⚠️ READ THE MOBILITY RULE FOR THIS POSITION
🔁 Please, spread the word

All the info here 👉 www.cnag.eu/jobs/phd-stu...

#PhDlife #Genomics #HoloGen #Barcelona
PhD Student - Structural Genomics Team (HoloGen Project) | CNAG, Centro Nacional de Análisis Genómico
MPORTANT MOBILITY RULE FOR THIS POSITION The MSCA mobility rule applies to this position: the applicant must not have resided or carried out their main activity (e.g., studies, work, research) in Spai...
www.cnag.eu
March 29, 2025 at 11:02 AM
Reposted by Irene Farabella
Celebrating 10 years of our lab with a new preprint:
www.biorxiv.org/content/10.1...
How does enhancer location within a TAD control transcriptional bursts from a cognate promoter?
Experiments by Jana Tünnermann and modelling by Gregory Roth
March 29, 2025 at 12:46 PM
Reposted by Irene Farabella
It's Day 2 of #EMBLAIOneHealth! 🎉

Today, participants heard a keynote from Giorgio Metta (Italian Institute of Technology (IIT), Italy) on artificial intelligence in RNA interactions, disease prediction, and therapeutic design.

📷 EMBL Photolab: Stuart Ingham
April 1, 2025 at 3:24 PM
🧬 We’re hiring a Postdoc in Genomic Data Science @IITalk! Join us to explore 3D genome architecture and RNAs using imaging, genomics & ML 💻🔬🐠
💼 Up to €45k/year
✅ PhD + Python/ML skills
➕ Experience with omics, imaging, or modelling = plus
📍 Genoa 🌊☀️
📧 [email protected]
🔗 tinyurl.com/6z52jhr9
Postdoc in Genomic Data Science
Commitment & contract: Post Doc 1 year collaboration contract, renewable Location: Centre for Human Technologies – Genoa At the Italian Institute of Technology (IIT), we are committed to advancing h...
tinyurl.com
April 1, 2025 at 2:33 PM
Reposted by Irene Farabella
🚨🚨 MEGA JOB ALERT 🚨🚨
Independent Group Leader Positions in Computational Biology @humantechnopole.bsky.social!

Are you ready to start your own lab? Do you know someone who is? Repost this + share with everyone who might want to know about it. Thanks!!! 🙏

More details below... check it out! 🧵 1/3
January 29, 2025 at 10:40 AM