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High-quality, topflight, and clinically impactful basic and translational research representative of all biomedical specialties and physician-scientists: https://insight.jci.org/
Dysregulated calcium signaling contributes to Alzheimer’s, but the molecular details are unresolved.
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
November 25, 2025 at 2:02 PM
Dysregulated calcium signaling contributes to Alzheimer’s, but the molecular details are unresolved.
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Here, Lauren H. Sansing & team report on changes of GLO1 with age & its association with calcium leak in degeneration, using mouse and macaque models: insight.jci.org/articles/vie...
Behind the Scenes: Authors Dominik Robak and Gaizun Hu investigate the intestinal epithelial barrier.
November 24, 2025 at 5:10 PM
Behind the Scenes: Authors Dominik Robak and Gaizun Hu investigate the intestinal epithelial barrier.
A high percentage of neonatal seizures resist treatment
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
November 11, 2025 at 2:03 PM
A high percentage of neonatal seizures resist treatment
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Joseph Glykys & team show recurrent neonatal seizures increases tonic inhibition through extrasynaptic GABAA receptors and respond to delta subunit selective GABAergic enhancers in mouse models: insight.jci.org/articles/vie...
Recently, a rare pediatric case revealed a role for Site1-protease in development and lipid metabolism.
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
November 5, 2025 at 2:03 PM
Recently, a rare pediatric case revealed a role for Site1-protease in development and lipid metabolism.
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...
Lijun Xia & team generated mouse models, discovering S1P/SREBP2-mediated cholesterol biosynthesis is necessary for lymphatic vascular development: insight.jci.org/articles/vie...