Seth Thomas Scanlon
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immunoeditor.bsky.social
Seth Thomas Scanlon
@immunoeditor.bsky.social
2.8K followers 250 following 210 posts
Editor, Science Immunology
science.org/journal/sciimmunol

🇺🇸 + 🇳🇱 & based in 🇪🇺

Twitter: x.com/ImmunoEditor
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immunoeditor.bsky.social
Nov issue of #Science #Immunology out now!

This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!

scim.ag/4qQA6Q6
ONLINE COVERB Cell Help Measures Up Against Parasites. How B cells acquire antigens from large pathogens, including single-celled parasites, to support T cell–driven humoral responses is not well understood. Gao et al. used Ighg2A10 B cells specific for the surface Plasmodium falciparum circumsporozoite protein (PfCSP) to examine the interaction between B cells and Plasmodium berghei sporozoites engineered to express PfCSP. Ighg2A10 B cells could internalize and present cognate and bystander surface antigens, which resulted in both intramolecular and intermolecular CD4 T cell help. This help either suppressed or supported protective B cell responses depending on whether the CD4 T cells recognized cytosolic or surface sporozoite antigens. This month’s cover is a pseudocolored and digitally altered scanning electron microscopy (SEM) micrograph of Plasmodium sporozoites (pale purple) attached to Ighg2A10 B cells (bright pink) at one end. Martin Oeggerli (Micronaut) 2025, with Xin Gao and Ian Cockburn, The John Curtin School of Medicine Research, Australian National University
November 7, 2025 at 10:19 PM
immunoeditor.bsky.social
Last week in #Science #Immunology: two papers from Bill Schief, Facundo Batista, @profshanecrotty.bsky.social, & al. provide evidence that simultaneous #immunization with multiple #bnAb #immunogens could be a viable #HIV #vaccine strategy!

Xie & al.
scim.ag/3W7wfQl

Sutton & al.
scim.ag/4ofvKQa
October 24, 2025 at 5:19 PM
immunoeditor.bsky.social
I'm so excited to be in stunning Stockholm for the 50th annual meeting of the #Scandinavian Society for #Immunology!

swimm.se/ssi-2025/

@finnsocimm.bsky.social @swimm-immuno.bsky.social @yssi-immunology.bsky.social @ki.se
Main stage of the Aula Medica auditorium in Stockholm, Sweden. Three people are standing near the lectern on stage. Text on the screen above the stage reads "50th annual meeting of the Scandinavian Society for Immunology" and features the SSI logo.
October 15, 2025 at 7:38 AM
immunoeditor.bsky.social
To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!

bit.ly/SciImm_free
October 9, 2025 at 5:43 PM
immunoeditor.bsky.social
The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week!

scim.ag/46TGooP
Decoding the Brain Tumor Immune Microenvironment. Brain tumors originate either from within the brain or as metastases from other tissues and pose major clinical challenges because of their heterogenous and aggressive nature. Bunse et al. review the cellular and molecular determinants of brain tumor antigenicity and factors that contribute to the immunosuppressive brain tumor microenvironment (TME). This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain. Credit: Rioka Hayama
October 3, 2025 at 8:08 PM
immunoeditor.bsky.social
The September issue of #Science #Immunology is out! This week: METTL1 m⁷G RNA modification of NAD+ #metabolism → #macrophage -mediated #inflammation; proenkaphalin+ #Tregs restrain skin inflamm via control of #nociception; #RNA helicase DDX55 is regulator of naïve #TCell homeostasis

scim.ag/3HKC5DP
Shining a Light on Naïve T Cell Homeostasis: Homeostatic maintenance of naïve T cells is critical to maintain a large and diverse T cell pool. However, the underlying mechanisms regulating this process are not well understood. Wu et al. report that the RNA helicase DDX55 regulates the homeostatic maintenance of naïve T cells by preventing MYC from binding to enhancer- and promoter-like transposable elements (TEs) near T cell activation genes. In naïve T cells, DDX55 prevents the inappropriate activation of TEs and ensures their genomic stability by preventing R-loop formation. This month’s cover features a light bulb with its filament stylized as a DNA double helix. Its left half glows with an intact filament, symbolizing TEs as regulators, and its right side is dimmed and features a broken filament, representing TEs’ disruptive potential. Credit: Bingyu Yang and Jianling Zhu/Sichuan University
September 5, 2025 at 6:23 PM
immunoeditor.bsky.social
The cover was illustrated by Rioka Hayama, who also designed #Science #Immunology 's wicked JAN 2025 cover!

riokahayama.com
August 12, 2025 at 8:41 PM
immunoeditor.bsky.social
This week's @science.org #IMMUNOLOGY-themed SPECIAL ISSUE features Reviews by {Kassiotis & Stoye}, {Nahrendorf, Ginhoux, & Swirski}, {Sharma, Gibbons, & Saphire}, & {@jessmetcalf.bsky.social, @grahammunology.bsky.social, Yates, & Cummings} + an absolutely wild & wonderful cover!

scim.ag/3UqRrA6
COVER This illustration depicts the changes in the immune system throughout an individual’s life span, from infancy to childhood, adulthood, and older age. The infant silhouette contains DNA, and the figures are enveloped by the nuclear and plasma membranes. These components reference the evolution of immunity over millennia, as viruses integrated into the genome and as life progressed from single-celled to multicellular organisms. See the special section beginning on page 586. Illustration: Rioka Hayama
August 12, 2025 at 8:32 PM
immunoeditor.bsky.social
The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice!

wwwscience.org/toc/sciimmun...
August 1, 2025 at 8:21 PM
immunoeditor.bsky.social
The July issue of #Science #Immunology is out now! This week:

• Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy!

• Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut!

New content each week!

www.science.org/toc/sciimmun...
Checkpoint on Type 2 Immunity. Tuft cells play key roles in the initiation and propagation of type 2 immune responses in the gut, but whether they have regulatory machinery for constraining these responses is not known. Wang et al. found that the transcription factor Spi-B prevents excessive type 2 immune responses against helminth infection and food allergens by limiting tuft cell activation and proliferation in the small intestine. Spi-B represses c-Kit signaling in tuft cells, which limits their production of the cytokine TSLP and the subsequent activation of T helper 2 (TH2) cells. This month’s cover image features a tuft cell (dark red) within the epithelial lining of the small intestine in which Spi-B has been inactivated, leading to increased production of TSLP by tuft cells and the cytokine interleukin-13 (IL-13) by TH2 cells (white). Credit: A. Fisher/Science Immunology
July 4, 2025 at 10:34 PM
immunoeditor.bsky.social
I am so delighted to be in #Japan for this year's RIKEN IMS–JSI International Symposium on #Immunology! 🇯🇵

温かく迎えてくれた主催者に感謝する！
June 27, 2025 at 2:44 AM
immunoeditor.bsky.social
To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025

bit.ly/SciImm_free
June 25, 2025 at 1:56 PM
immunoeditor.bsky.social
This month in #Science #Immunology, Shivangi Dave & André Ballesteros Tato at the #NIH review the noncanonical contributions of #TFollicularHelper ( #TFH ) cells cells to immune regulation beyond their traditional roles in #BCell help!

science.org/doi/10.1126/sciimmunol.adr1052
Conventional and nonconventional functions of TFH cells: In addition to their conventional role as GC facilitators—providing survival and proliferation signals to GC B cells—TFH cells also perform noncanonical functions. They can support CD8+ T cell responses, produce effector-like cytokines that critically influence B cell fate decisions beyond GC maintenance, and exhibit TSCM properties that allow them to serve as reservoirs for pathogenic Teff cell subsets across various anatomical niches
June 18, 2025 at 10:50 AM
immunoeditor.bsky.social
The June issue of #Science #Immunology has launched! This week: inducible #FoxP3 degradation in #Tregs; the immune landscape of human #psoriatic #arthritis; & #IL12 gives #mRNA #vaccines a boost!

New content every week! Check it out!

www.science.org/toc/sciimmun...
ONLINE COVERLNP mRNA Vaccines Get a Boost. Lipid nanoparticle (LNP) mRNA vaccines induce robust immune responses and provide protection against infectious diseases, but this immunity can be short-lived, necessitating frequent booster vaccinations. Aunins et al. investigated how adjuvanting LNP-mRNA vaccines with mRNA encoding the cytokine interleukin-12 (IL-12) influences CD8 T cell responses in mice. Il12 mRNA-LNPs (LNP–IL-12) enhanced antigen-specific CD8 T cell responses and CD8 T cell memory, providing greater protection against bacterial infection and in a mouse model of melanoma. Cytokine-adjuvanted mRNA-LNPs may help future vaccine platforms better tailor the magnitude and nature of the immune response. This month’s cover image features a stylized mRNA-LNP with various lipid (red, coral, and pink) and cholesterol molecules (maroon) encapsulating Il12 mRNA (yellow). Credit: A. Mastin/Science Immunology
June 6, 2025 at 7:22 PM
immunoeditor.bsky.social
Austin is so talented! Here's his illustration for the Science Immunology Feb 2024 cover, drawn in a markedly different style!
May 30, 2025 at 8:36 PM
immunoeditor.bsky.social
The May issue of #Science #Immunology is out now!

This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes!

science.org/toc/sciimmunol/10/107
ONLINE COVER: Lymph Nodes Get a Remodel. Fibroblastic reticular cells (FRCs) are stromal cells that coordinate structural remodeling and adaptive immune responses in the lymph node. Using single-cell transcriptomics and high-resolution microscopy, Lütge et al. comprehensively characterized the stromal cell landscape of human lymph nodes during quiescence and inflammation. Inflammation drove lymph node remodeling including the expansion of peptidase inhibitor 16 (PI16)+ FRCs in macrophage-rich perivascular niches. This month’s cover image shows an inflamed human lymph node that has undergone expansion of podoplanin+ FRCs (purple) near alpha smooth muscle actin (ACTA2)+ vascular smooth muscle cells (green) to support immune cell infiltration and BCL6+ germinal center B cell (orange) activity. Credit: Lisa Kurz/Kantonsspital St. Gallen
May 2, 2025 at 8:25 PM
immunoeditor.bsky.social
In sunny Freiburg for the International Symposium on #Perinatal and #EarlyLife #Immunity!

www.perinatal-immunity.de/en/symposium...
April 10, 2025 at 7:14 AM
immunoeditor.bsky.social
The March issue is out! This week: TOX-inducible-KO 🐁show how #TOX maintains #exhausted CD8 #Tcell epigenetic fate; visualizing temporal & spatial #STING expression; & UVB-driven #mitochondrial Z-🧬complexed w ZBP1 fuels #autoimmune #photosensitivity via cGAS-STING!

science.org/toc/sciimmunol/10/105
This month’s cover features a keratinocyte mitochondrion damaged by UVB radiation, which then releases reactive oxygen species (red spheres) and Z-DNA complexed with ZBP1 into the cytoplasm. (Credit: A. Fisher/Science Immunology)
March 7, 2025 at 8:07 PM
immunoeditor.bsky.social
To celebrate with the @keystonesymposia.bsky.social #myeloid cell meeting happening now in Hannover, we have released a free collection of 6 recent #Science #Immunology papers focused on myeloid cells!

Check 'em out! They will be available until the end of April!

bit.ly/SciImm_free

#KSmyeloid25
March 5, 2025 at 11:39 PM
immunoeditor.bsky.social
To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org
The February 2024 cover of Science Immunology depicts CRISPR–Cas9–mediated repair of a dysfunctional cytotoxic T cell (red) from an individual with familial hemophagocytic lymphohistiocytosis (FHL), which allows it to secrete normal cytotoxic granules (pink) and effectively kill virally infected B cells (blue). (Credit: A. Fisher/Science Immunology)
February 28, 2025 at 9:37 PM
immunoeditor.bsky.social
Ha ha! The Vince Lombardi is ours! Phellow Philadelphians: rejoice!
February 10, 2025 at 3:26 AM
immunoeditor.bsky.social
Our February issue is now live! This week: CD22 restrains #IL4 -driven #TVMcell expansion during #helminth infection; molecular determinants of #TCR x-reactivity against #influenza variants; & #MultipleMyeloma breakout lesions are tumor–immune interaction hotspots!

science.org/toc/sciimmunol/10/104
February 7, 2025 at 7:31 PM
immunoeditor.bsky.social
#Paris lab visits day 2: @pasteur.fr! Un grand merci to all the researchers who shared their exciting data with me today! Formidable!
Bust of Ilya Mechnikov, Pasteur Institute, Paris, France
February 4, 2025 at 6:10 PM
immunoeditor.bsky.social
I would like to send a great big thank you to the many researchers who made my visit to @institutcurie.bsky.social today so wonderful!
Mural of scientist Marie Curie (Paris, France)
February 3, 2025 at 8:14 PM
immunoeditor.bsky.social
At AAAS headquarters & just caught a terrific gallery show curated by @science.org Visuals team. "The invisible, novel, and complex: A decade of visualizing science" highlights a selection of eye-popping covers, photos, and custom illustrations from the past 10 years. In DC? Be sure to check it out!
January 8, 2025 at 7:47 PM