Hua Zhang
@huazhanglab.bsky.social
Assistant Professor at University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center. Our lab works to improve our understanding of lung cancer.
Very excited to share our work on targeted degradation of KRAS G12V, where we demonstrated the power of the dTAG approach in a lung cancer GEMM. This work is a collaborative effort from @behnamnabet.bsky.social (Fred Hutch), Kwok-kin Wong (NYU), @huazhanglab.bsky.social (UPitt) and others.
🧪 Ready, set, degrade!
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
So proud to share our work in the @jclinical-invest.bsky.social, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer.
Link: www.jci.org/articles/vie...
December 29, 2024 at 5:16 PM
Very excited to share our work on targeted degradation of KRAS G12V, where we demonstrated the power of the dTAG approach in a lung cancer GEMM. This work is a collaborative effort from @behnamnabet.bsky.social (Fred Hutch), Kwok-kin Wong (NYU), @huazhanglab.bsky.social (UPitt) and others.