Clair Crewe et al. offer a roadmap for studying extracellular vesicles (EVs), emphasizing plasma preparation, lipoprotein clearance, accurate particle dosing, and uptake validation to ensure reproducible results. @natmetabolism.nature.com doi.org/10.1038/s422... 🧪

Why should you consider adding refractive index measurements to your regular nanoparticle analysis?

Exosome tethering requires tetherin homodimerisation www.biorxiv.org/content/10.1...

What is holographic microscopy?
And why are we so excited about it’s scientific potential?

Size is a key descriptor of extracellular vesicles #EV. In samples containing contaminating particles with an overlapping size distribution, size alone is insufficient. Measuring refractive index at the individual particle level enables differentiation of extracellular vesicles and lipoproteins.

Excited to share this pre-print from our collaborators, the Edgar lab, at the University of Cambridge, UK
www.linkedin.com/posts/james-...

What is DAISY?
DAISY is next generation nanoparticle tracking analysis!

We will also be presenting at the European National Societies of Extracellular Vesicles MOVE symposium in Tartu, Estonia Oct 7th to 9th:
move2025.ee
See you there!

It is shaping up be a busy autumn! HOLTRA are excited to be presenting our technology at the European Colloid and Interface Society meeting in Bristol, UK. Sept. 7th to 12th
www.ecis-web.eu/about-us/eci...

DAISY can see inside your liposomes and lipid nanoparticle preparations to reveal internal structure!
Read more here:
www.holtra.tech/en/applicati...

DAISY nanoparticle tracking in action!
sample is 415 nm silica beads

Do you want to easily identify and quantify contaminants and aggregates in your extracellular vesicle samples?
Take a look at our EV application note to find out how DAISY can improve your EV analysis:
www.holtra.tech/en/applicati...

Check out our updated website for an overview of our technology and real-world applications in nanoparticle analysis:
www.holtra.tech