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hittingerlab.bsky.social
HittingerLab
@hittingerlab.bsky.social
460 followers 610 following 44 posts
Yeast evolutionary genomics with applications in brewing and bioenergy at the University of Wisconsin-Madison. Moderated by Hittinger Lab members. Opinions do not necessarily belong to anyone. Lab website: http://hittinger.genetics.wisc.edu.
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hittingerlab.bsky.social
ECAR variation is associated with glycolyitc genes across the yeast subphylum (Figure 1 in this work)
https://www.biorxiv.org/content/10.1101/2025.10.02.679963v2
October 7, 2025 at 5:14 PM
hittingerlab.bsky.social
Congrats to @emuthemycologist.bsky.social for presenting her first talk at #MSAfungi25!
July 2, 2025 at 9:52 PM
hittingerlab.bsky.social
Congratulations to @linder-surprise.bsky.social for winning an award for mentoring undergraduates from the office of the Provost! 🎉

@glbioenergy.bsky.social @uwenergy.bsky.social
May 15, 2025 at 3:35 PM
hittingerlab.bsky.social
Congratulations to Katarina Aranguiz for being recognized with an award for best poster at the UW-Madison Fungal Supergroup Undergraduate Symposium!

@glbioenergy.bsky.social @uwbiochem.bsky.social
May 6, 2025 at 6:37 PM
hittingerlab.bsky.social
Congratulations to Lizza Korolev for being awarded the Hilldale Fellowship to support her undergraduate research!
@glbioenergy.bsky.social @uwenergy.bsky.social @tksato.bsky.social
Lizza holds up a certificate for her fellowship
April 30, 2025 at 3:52 PM
hittingerlab.bsky.social
Importantly, this also decreases the variation in fermentation from different harvest years of switchgrass:
A graph showing that increasing the pH from 5 to 5.8 increases ethanol yields from switchgrass hydrolysate.
January 21, 2025 at 4:44 PM
hittingerlab.bsky.social
In case you happen to be in Tokyo, Masako Takashima organized on "Yeasts and fermentation: progress brought by genomic data" tomorrow afternoon, 13th December 2024: nodaiweb.university.jp/nric/yeast/i...
December 12, 2024 at 5:29 AM
hittingerlab.bsky.social
We also zoomed out to look at the (very large) Major Facilitator Superfamily across diverse yeasts and found that these specialized alpha-glucoside transporters likely evolved from a generalist ancestral transporter.

See the full paper for more!
December 2, 2024 at 8:11 PM
hittingerlab.bsky.social
Turns out that multiple simultaneous mutations are required for this - explaining why our evolved isolate had a chimeric transporter.
Fig. 2.High-order intramolecular interactions are required to evolve a novel function in chimeric α-glucoside transporters. Points and bars show mean ± standard error of the mean of normalized growth on maltotriose (AUC) of strains expressing chimeric transporters or wild-type MalT4 (top row). Filled circles denote growth significantly greater than the negative control (P < 0.01, Mann–Whitney U test with Benjamini–Hochberg correction). The architecture of each tested transporter is depicted as a cartoon on the y axis, where rounded rectangles represent each of the 12 TMHs and circles represent the ICH domain that links the N- and C-terminal six-helix bundles; regions are colored by parental protein identity. In almost every case, the N- and C-terminal intracellular regions have the same parental protein identity as the neighboring TMH and are omitted for clarity; the two exceptions are depicted. Inverted arrows and brackets indicate the location and identity of protein regions underlying the largest detected intramolecular interaction.
December 2, 2024 at 8:11 PM