Helena Schulz-Mirbach
@helenasm.bsky.social
PhD student rewiring E. coli for synthetic C1 assimilation
Amazing work led by Vittorio Rainaldi from the lab of @nicoc-micsynmet.bsky.social on realizing the majority of the rMASP cycle for #synthetic #co2 #fixation in E. coli!
#Ccr, the key carboxylase of the CETCH, THETA and HOPAC cycles finally works #invivo !
#Ccr, the key carboxylase of the CETCH, THETA and HOPAC cycles finally works #invivo !
Newest preprint from our lab: a new family of promising synthetic CO2 fixation cycles that may outcompete the Calvin cycle and that Vittorio Rainaldi realized to a great extent in E. coli! Up to 11 heterologous enzymes in a cascade supporting CO2 fixation & growth! www.biorxiv.org/content/10.1...
Modular in vivo engineering of the reductive methylaspartate cycles for synthetic CO2 fixation
Biological carbon fixation is currently limited to seven naturally occurring pathways. Synthetic carbon fixation pathways have the potential to surpass aerobic natural pathways in efficiency, but none...
www.biorxiv.org
November 25, 2025 at 6:44 PM
Amazing work led by Vittorio Rainaldi from the lab of @nicoc-micsynmet.bsky.social on realizing the majority of the rMASP cycle for #synthetic #co2 #fixation in E. coli!
#Ccr, the key carboxylase of the CETCH, THETA and HOPAC cycles finally works #invivo !
#Ccr, the key carboxylase of the CETCH, THETA and HOPAC cycles finally works #invivo !
Reposted by Helena Schulz-Mirbach
🔥🔥🔥 Friday Evening, Paper Out, Feierabend 🔥🔥🔥
When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.
doi.org/10.1016/j.ym...
When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.
doi.org/10.1016/j.ym...
Redirecting
doi.org
October 24, 2025 at 5:00 PM
🔥🔥🔥 Friday Evening, Paper Out, Feierabend 🔥🔥🔥
When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.
doi.org/10.1016/j.ym...
When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy.
doi.org/10.1016/j.ym...
Reposted by Helena Schulz-Mirbach
Please repost!
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
efzu.fa.em2.oraclecloud.com
September 12, 2025 at 11:43 AM
Please repost!
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!
Location: DTU Biosustain
🦠🧬🔬
Starting in 01/2026!
Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...
Reposted by Helena Schulz-Mirbach
Our perspective on C1 utilizing bioprocesses moved online, a super teamwork made it possible 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Industrial applicability of enzymatic and whole-cell processes for the utilization of C1 building blocks - Nature Communications
Significant process has been made in using one carbon sources toward biomanufacturing. Here, the authors explore how to strength its competitiveness, and highlight latest technologies and the released...
www.nature.com
August 1, 2025 at 6:46 PM
Our perspective on C1 utilizing bioprocesses moved online, a super teamwork made it possible 👏
www.nature.com/articles/s41...
www.nature.com/articles/s41...
#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Escherichia coli selection strains for growth-coupled metabolic engineering
Synthetic metabolism has the potential to transform carbon capture, bioremediation, or bioproduction strategies. To transfer metabolic designs from an…
www.sciencedirect.com
July 12, 2025 at 3:57 PM
#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Helena Schulz-Mirbach
#ME16
This is quite subjective , but imo
@helenasm.bsky.social just gave the most impressive talk of the conference so far and she is "only" in the third year of her PhD.
If you are interested in synthetic pathway engineering or C1 fixation you should check out her research.
This is quite subjective , but imo
@helenasm.bsky.social just gave the most impressive talk of the conference so far and she is "only" in the third year of her PhD.
If you are interested in synthetic pathway engineering or C1 fixation you should check out her research.
scholar.google.com
June 16, 2025 at 1:45 PM
#ME16
This is quite subjective , but imo
@helenasm.bsky.social just gave the most impressive talk of the conference so far and she is "only" in the third year of her PhD.
If you are interested in synthetic pathway engineering or C1 fixation you should check out her research.
This is quite subjective , but imo
@helenasm.bsky.social just gave the most impressive talk of the conference so far and she is "only" in the third year of her PhD.
If you are interested in synthetic pathway engineering or C1 fixation you should check out her research.
Reposted by Helena Schulz-Mirbach
Excited to share a main project from my PhD, out now in
@naturecomms.bsky.social! 📝
We've designed and brought to life the “CORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱
nature.com/articles/s41...
Take a look! Thread below... 🧵
@naturecomms.bsky.social! 📝
We've designed and brought to life the “CORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱
nature.com/articles/s41...
Take a look! Thread below... 🧵
April 4, 2025 at 10:03 AM
Excited to share a main project from my PhD, out now in
@naturecomms.bsky.social! 📝
We've designed and brought to life the “CORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱
nature.com/articles/s41...
Take a look! Thread below... 🧵
@naturecomms.bsky.social! 📝
We've designed and brought to life the “CORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱
nature.com/articles/s41...
Take a look! Thread below... 🧵
Reposted by Helena Schulz-Mirbach
We just #published an end-to-end work for the computer-aided design💻, construction🛠️, validation✅, characterization🔬 & application💪 of #auxotroph metabolic sensors, the work-horses of in vivo growth-coupled selection screening systems-using glycolate as test case. 🧵👇1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
March 4, 2025 at 8:38 PM
We just #published an end-to-end work for the computer-aided design💻, construction🛠️, validation✅, characterization🔬 & application💪 of #auxotroph metabolic sensors, the work-horses of in vivo growth-coupled selection screening systems-using glycolate as test case. 🧵👇1/
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Really happy to share that our work on constructing six glyoxylate / glycolate sensors covering a three order of magnitude concentration range is out now in Nature Communications ! 🔥
Read below to see how we developed the sensors and what they are good for 🥳.
www.nature.com/articles/s41...
Read below to see how we developed the sensors and what they are good for 🥳.
www.nature.com/articles/s41...
Computation-aided designs enable developing auxotrophic metabolic sensors for wide-range glyoxylate and glycolate detection - Nature Communications
Auxotrophic metabolic sensors (AMS) are vital for bioengineering but are often time-consuming to develop. Here, the authors present a workflow for designing versatile AMS, demonstrating their use for ...
www.nature.com
March 4, 2025 at 6:03 PM
Really happy to share that our work on constructing six glyoxylate / glycolate sensors covering a three order of magnitude concentration range is out now in Nature Communications ! 🔥
Read below to see how we developed the sensors and what they are good for 🥳.
www.nature.com/articles/s41...
Read below to see how we developed the sensors and what they are good for 🥳.
www.nature.com/articles/s41...