HarrisTryon Lab
@harristryonlab.bsky.social
Welcome! We are uncovering how bacteria impact skin health and disease. My views are my own. #dermtwitter. @LHooperLab, @hopkinsmedicine @haverfordedu alum.
11/11These findings, supported by
@BWFPATH, are even more fascinating in the context of our work @theJIDJournal led by @JPineider @HunterJPyle., Melissa Mauskar showing site-, disease-, and sex-dependent differences in the secretion of androgens at the skin surface. Links below.
@BWFPATH, are even more fascinating in the context of our work @theJIDJournal led by @JPineider @HunterJPyle., Melissa Mauskar showing site-, disease-, and sex-dependent differences in the secretion of androgens at the skin surface. Links below.
January 14, 2025 at 5:08 PM
11/11These findings, supported by
@BWFPATH, are even more fascinating in the context of our work @theJIDJournal led by @JPineider @HunterJPyle., Melissa Mauskar showing site-, disease-, and sex-dependent differences in the secretion of androgens at the skin surface. Links below.
@BWFPATH, are even more fascinating in the context of our work @theJIDJournal led by @JPineider @HunterJPyle., Melissa Mauskar showing site-, disease-, and sex-dependent differences in the secretion of androgens at the skin surface. Links below.
10/11 In an exciting final twist, we can leverage this conversation between host hormones and bacteria for #therapeutics to decrease S. aureus virulence, with an enantiomer of testosterone, inhibiting expression of PSMs, red blood cell hemolysis and neutrophil killing.
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January 14, 2025 at 5:08 PM
10/11 In an exciting final twist, we can leverage this conversation between host hormones and bacteria for #therapeutics to decrease S. aureus virulence, with an enantiomer of testosterone, inhibiting expression of PSMs, red blood cell hemolysis and neutrophil killing.
9/11…testosterone cannot activate strains that lack AgrCA. Together, our findings illuminate a molecular conversation between S. aureus and the host through the sensing of testosterone and DHT.
January 14, 2025 at 5:08 PM
9/11…testosterone cannot activate strains that lack AgrCA. Together, our findings illuminate a molecular conversation between S. aureus and the host through the sensing of testosterone and DHT.
8/11 … both in mouse models and in culture, testosterone is sufficient to activate quorum sensing without the need for the autoinducer, AIP-I. However…
January 14, 2025 at 5:08 PM
8/11 … both in mouse models and in culture, testosterone is sufficient to activate quorum sensing without the need for the autoinducer, AIP-I. However…
7/11 …the impact of testosterone on S. aureus transcription is highly specific, narrowly activating transcripts in the agr signaling pathway.
@rebecca_keogh. Further, …
@rebecca_keogh. Further, …
January 14, 2025 at 5:08 PM
7/11 …the impact of testosterone on S. aureus transcription is highly specific, narrowly activating transcripts in the agr signaling pathway.
@rebecca_keogh. Further, …
@rebecca_keogh. Further, …
6/11 …further dissected this phenotype in culture and show that testosterone and dihydrotestosterone (DHT) activate the expression of agr quorum sensing pathways in S. aureus, including stimulation of virulence factors, such as the phenol soluble modulins (PSMs). In fact…
January 14, 2025 at 5:08 PM
6/11 …further dissected this phenotype in culture and show that testosterone and dihydrotestosterone (DHT) activate the expression of agr quorum sensing pathways in S. aureus, including stimulation of virulence factors, such as the phenol soluble modulins (PSMs). In fact…
5/11 Next, with tools generated in the lab of Alex Horswill by @mohinibattharya, we…
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January 14, 2025 at 5:08 PM
5/11 Next, with tools generated in the lab of Alex Horswill by @mohinibattharya, we…
4/11 …generated mice defective in hormone synthesis at the skin surface and show that without hormone secretion in the skin, mice are resistant to skin infection with S. aureus.
January 14, 2025 at 5:08 PM
4/11 …generated mice defective in hormone synthesis at the skin surface and show that without hormone secretion in the skin, mice are resistant to skin infection with S. aureus.
3/11...IL4 signaling regulates androgen production in sebaceous glands, leading @harristryonlab
to wonder whether testosterone might stimulate virulence in S. aureus, allowing it to colonize the skin in #atopicdermatitis. To test this we…
to wonder whether testosterone might stimulate virulence in S. aureus, allowing it to colonize the skin in #atopicdermatitis. To test this we…
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ALT: a bald man wearing 3d glasses is screaming with his mouth open
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January 14, 2025 at 5:08 PM
3/11...IL4 signaling regulates androgen production in sebaceous glands, leading @harristryonlab
to wonder whether testosterone might stimulate virulence in S. aureus, allowing it to colonize the skin in #atopicdermatitis. To test this we…
to wonder whether testosterone might stimulate virulence in S. aureus, allowing it to colonize the skin in #atopicdermatitis. To test this we…
2/11 S. aureus is the most common cause of skin infections, yet it rarely colonizes healthy skin.
During inflammation, like #atopicdermatitis and #eczema S. aureus begins to dominate. Infections are also more common in men. Our lab showed in 2021@PNASNews that…
During inflammation, like #atopicdermatitis and #eczema S. aureus begins to dominate. Infections are also more common in men. Our lab showed in 2021@PNASNews that…
January 14, 2025 at 5:08 PM
2/11 S. aureus is the most common cause of skin infections, yet it rarely colonizes healthy skin.
During inflammation, like #atopicdermatitis and #eczema S. aureus begins to dominate. Infections are also more common in men. Our lab showed in 2021@PNASNews that…
During inflammation, like #atopicdermatitis and #eczema S. aureus begins to dominate. Infections are also more common in men. Our lab showed in 2021@PNASNews that…