Han Xu
@hanxu-mdacc.bsky.social
Associate professor at MD Anderson Cancer Center.
My lab uses high-throughput CRISPR perturbation screening methods to understand protein functions and their roles in cancer.
My lab uses high-throughput CRISPR perturbation screening methods to understand protein functions and their roles in cancer.
Reposted by Han Xu
Nature research paper: Comprehensive interrogation of synthetic lethality in the DNA damage response
https://go.nature.com/42878AI
https://go.nature.com/42878AI
Comprehensive interrogation of synthetic lethality in the DNA damage response - Nature
Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in preventing under-replication and SMARCAL1 and FANCM in remodelling persistent cruciform DNA structures.
go.nature.com
April 12, 2025 at 1:12 PM
Nature research paper: Comprehensive interrogation of synthetic lethality in the DNA damage response
https://go.nature.com/42878AI
https://go.nature.com/42878AI