Great talk by David Olson UCDavis yesterday at UCSD. Impressive voyage through drug discovery, chemistry and systems neuroscience. www.science.org/doi/10.1126/...

5/6: The responses are anatomically separated in MEC (but not in POR).

4/6: While POR neurons respond to cues and cue-outcome associations - only a few MEC neurons develop visual cue selectivity, but large populations develop a bias towards the reward or the cue-reward association

3/6: A large fraction of POR neurons are visual cue-responsive from the beginning as mice begin to learn the task, while MEC neurons develop responses especially to the plus cue during learning.

2/6: We compare the neural dynamics in postrhinal (POR) and medical entorhinal cortex (MEC) as mice learn a visual Go/NoGo task. Same cells recorded from completely naïve to expert and through rule reversal.

New preprint out in eLife! Neurons in medical entorhinal cortex (MEC) develop responses to visual cues and reward as mice learn a visual Go/NoGo task. elifesciences.org/reviewed-pre...

Strikingly different responses to visual stimuli in postrhinal (POR) cortex compared to MEC. Following the same neurons through the learning process. Single cell example from each region below.