Guim Aguadé-Gorgorió
@guimaguade.bsky.social
Marie Skłodowska-Curie fellow at ISEM Montpellier. Physicist studying complex biological systems - ecosystems, cancer, immune networks and microbial communities.
A central finding is that, even if we could measure pairwise interactions up to a certain precision, strong indirect effects can make our efforts useless: at high collectivity, pairwise interactions no longer inform about community coexistence
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 12, 2025 at 10:28 AM
A central finding is that, even if we could measure pairwise interactions up to a certain precision, strong indirect effects can make our efforts useless: at high collectivity, pairwise interactions no longer inform about community coexistence
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Some tumors with many mutations are eliminated by immunotherapy, while others evade immune surveillance and eventually relapse. A new mathematical model could help us understand the complex role of mutational load in immunotherapy resistance www.biorxiv.org/content/10.1... @ricardsole.bsky.social
August 13, 2025 at 8:44 AM
Some tumors with many mutations are eliminated by immunotherapy, while others evade immune surveillance and eventually relapse. A new mathematical model could help us understand the complex role of mutational load in immunotherapy resistance www.biorxiv.org/content/10.1... @ricardsole.bsky.social
Immunotherapy fails at curing heterogeneous cancers. Why? Modeling and clinical data suggest a limit to tumor heterogeneity, beyond which T cells fail at controlling highly-diverse tumors. Can we take advantage of this limit? @ricardsole.bsky.social royalsocietypublishing.org/doi/full/10....
June 2, 2025 at 2:59 PM
Immunotherapy fails at curing heterogeneous cancers. Why? Modeling and clinical data suggest a limit to tumor heterogeneity, beyond which T cells fail at controlling highly-diverse tumors. Can we take advantage of this limit? @ricardsole.bsky.social royalsocietypublishing.org/doi/full/10....
Our work is based on two great recent articles that strongly impacted the way I think about complexity in ecology. Inspiring! @changyuchang.bsky.social @asanchezlab.bsky.social
May 22, 2025 at 5:42 AM
Our work is based on two great recent articles that strongly impacted the way I think about complexity in ecology. Inspiring! @changyuchang.bsky.social @asanchezlab.bsky.social
Microbial communities can harbor many species that do not coexist in pairs, yet can coexist in the full community. Here we provide the mathematical foundations of emergent coexistence, and explain why it can't be predicted from pairwise tests www.biorxiv.org/content/10.1...
May 20, 2025 at 1:16 PM
Microbial communities can harbor many species that do not coexist in pairs, yet can coexist in the full community. Here we provide the mathematical foundations of emergent coexistence, and explain why it can't be predicted from pairwise tests www.biorxiv.org/content/10.1...
Tumors harbor hundreds of different cell types that compete and cooperate, mirroring a natural ecosystem. Can we model cancer as a complex ecosystem of many interacting species?
An honor to work w/ @ricardsole.bsky.social and Sandy Anderson while bringing in recent work in ecology with Sonia Kéfi!
An honor to work w/ @ricardsole.bsky.social and Sandy Anderson while bringing in recent work in ecology with Sonia Kéfi!
January 13, 2025 at 11:06 AM
Tumors harbor hundreds of different cell types that compete and cooperate, mirroring a natural ecosystem. Can we model cancer as a complex ecosystem of many interacting species?
An honor to work w/ @ricardsole.bsky.social and Sandy Anderson while bringing in recent work in ecology with Sonia Kéfi!
An honor to work w/ @ricardsole.bsky.social and Sandy Anderson while bringing in recent work in ecology with Sonia Kéfi!