Lea H. Gregersen
@gregersenlab.bsky.social
Group leader at @UCPH_health, working on RNA-binding proteins and co-transcriptional regulation. Previously at @UPCH_BRIC,
@BIMSB_MDC and @TheCrick
@BIMSB_MDC and @TheCrick
What happens to transcription upon oxidative DNA damage? 🧬💥
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...
Oxidative stress triggers RNAPII arrest through PARylation and DNA damage
UV or gamma irradiation, as well as certain chemicals, generate DNA damage that disrupts transcription through a variety of well-characterised mechanisms. In contrast, the transcriptional response to ...
www.biorxiv.org
November 7, 2025 at 12:13 PM
What happens to transcription upon oxidative DNA damage? 🧬💥
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...
RNAPII halts instantly within genes ⛔️ and even more surprisingly: It restarts from where it stopped without leaving the DNA template 🚦
👀📄 How does this happen? Find out in our new preprint👇 www.biorxiv.org/cgi/content/...
Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure rates across 3,000+ genes 🧬
genome.cshlp.org/content/earl...
This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors
Details below! 👇
genome.cshlp.org/content/earl...
This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors
Details below! 👇
Kinetic measurement of gene-specific RNA polymerase II transcription elongation rates
An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms
genome.cshlp.org
October 24, 2025 at 10:25 AM
Interested in measuring RNAPII elongation rates? We developed DRB/TTchem-seq2 to directly measure rates across 3,000+ genes 🧬
genome.cshlp.org/content/earl...
This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors
Details below! 👇
genome.cshlp.org/content/earl...
This fantastic work led by Haiyue Liu reveals gene and intra-genic variation, links to histone marks & elongation factors
Details below! 👇
Such a beautiful example of how tight control of transcriptional activity is achieved and even more important: plays a crucial developmental role. Congratulations @jzylicz.bsky.social and team!
Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
HDAC3 prevents enhancer hyperactivation to enable developmental transitions
Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...
www.biorxiv.org
September 18, 2025 at 12:47 PM
Such a beautiful example of how tight control of transcriptional activity is achieved and even more important: plays a crucial developmental role. Congratulations @jzylicz.bsky.social and team!
❗️One more week to apply for a PhD position in our group👇
We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @ucph.bsky.social. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com). It's a wonderful city and amazing research environment. Deadline March 6. jobportal.ku.dk/phd/?show=16...
February 28, 2025 at 12:39 PM
❗️One more week to apply for a PhD position in our group👇
Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @ucph.bsky.social in wonderful Copenhagen. Want to join our team to work on transcriptional regulation? More information at: gregersenlab.com Deadline March 18. Apply here: jobportal.ku.dk/phd/?show=16...
Gegersen Lab
The aim of the lab is to understand regulation of transcription and co-transcriptional processing in human cells
gregersenlab.com
February 21, 2025 at 8:56 AM
Another chance to join our group! Center for Gene Expression has 2 or more postdoc positions @ucph.bsky.social in wonderful Copenhagen. Want to join our team to work on transcriptional regulation? More information at: gregersenlab.com Deadline March 18. Apply here: jobportal.ku.dk/phd/?show=16...
We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @ucph.bsky.social. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com). It's a wonderful city and amazing research environment. Deadline March 6. jobportal.ku.dk/phd/?show=16...
February 13, 2025 at 8:09 PM
We are recruiting! Center for Gene Expression has 2 or more open positions for PhDs @ucph.bsky.social. Come join our team to work on RNAPII and transcriptional regulation (gregersenlab.com). It's a wonderful city and amazing research environment. Deadline March 6. jobportal.ku.dk/phd/?show=16...
Reposted by Lea H. Gregersen
Postdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...
Postdoc positions in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet
Ledig stilling ved Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation, Aarhus Universitet
mbg.au.dk
February 12, 2025 at 9:02 AM
Postdoc positions on nuclear RNA biology available in the Heick Jensen lab. Come join us in tiny Denmark. Interested? - then follow this link: mbg.au.dk/aktuelt/ledi...
Reposted by Lea H. Gregersen
We're hiring a motivated PhD student! Join reNEW @ucph.bsky.social & @nucleardn.bsky.social to study how metabolism regulates chromatin & stem cell fate thanks to generous Marie Skłodowska-Curie Fellowship. Remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.
February 7, 2025 at 3:20 PM
We're hiring a motivated PhD student! Join reNEW @ucph.bsky.social & @nucleardn.bsky.social to study how metabolism regulates chromatin & stem cell fate thanks to generous Marie Skłodowska-Curie Fellowship. Remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.
Reposted by Lea H. Gregersen
New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology
@molbiolau.bsky.social
mbg.au.dk/en/news-and-...
@molbiolau.bsky.social
mbg.au.dk/en/news-and-...
Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
February 7, 2025 at 12:41 PM
New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology
@molbiolau.bsky.social
mbg.au.dk/en/news-and-...
@molbiolau.bsky.social
mbg.au.dk/en/news-and-...
Reposted by Lea H. Gregersen
Now official: We have another opening for a fully funded #PhDposition in the Beusch lab (www.beuschlab.org) at @uniwuerzburg.bsky.social! More details here: tinyurl.com/947xcw85 If you or someone you know is curious about #splicing please apply or contact me for more information! #RNAsky #RNAbiology
PhD-Beusch_202501_final.pdf
tinyurl.com
January 29, 2025 at 8:52 AM
Now official: We have another opening for a fully funded #PhDposition in the Beusch lab (www.beuschlab.org) at @uniwuerzburg.bsky.social! More details here: tinyurl.com/947xcw85 If you or someone you know is curious about #splicing please apply or contact me for more information! #RNAsky #RNAbiology