Gonzalo Parra
@gonzaparra.bsky.social
Ramón y Cajal Junior Group Leader @BSC_CNS 🇦🇷🇪🇸🏳️🌈 ENFJ | Bioinformatics | 3DSIG Co-Chair | @fi_uner, @exactas_uba, @mpi_bpc, @embl, @dkfz alumnus | @iscb BoD | Opinions my own
Interesting work that we conducted from the Student Council of
@iscb.bsky.social to estimate the impact of the COVID19 pandemics on early career researchers in computational biology!
Thanks for leading this effort Farzana Rahman and to the entire team!
journals.plos.org/ploscompbiol...
@iscb.bsky.social to estimate the impact of the COVID19 pandemics on early career researchers in computational biology!
Thanks for leading this effort Farzana Rahman and to the entire team!
journals.plos.org/ploscompbiol...
October 15, 2025 at 9:05 PM
Interesting work that we conducted from the Student Council of
@iscb.bsky.social to estimate the impact of the COVID19 pandemics on early career researchers in computational biology!
Thanks for leading this effort Farzana Rahman and to the entire team!
journals.plos.org/ploscompbiol...
@iscb.bsky.social to estimate the impact of the COVID19 pandemics on early career researchers in computational biology!
Thanks for leading this effort Farzana Rahman and to the entire team!
journals.plos.org/ploscompbiol...
A collab referred me to this paper which I of course read when it came out in 2013. However, as a mid-way PhD student my capacity to deeply understand its details was pretty limited. 12 years later, I can understand much more! I really recomend this jewel!
doi.org/10.1063/1.48...
doi.org/10.1063/1.48...
October 14, 2025 at 7:28 PM
A collab referred me to this paper which I of course read when it came out in 2013. However, as a mid-way PhD student my capacity to deeply understand its details was pretty limited. 12 years later, I can understand much more! I really recomend this jewel!
doi.org/10.1063/1.48...
doi.org/10.1063/1.48...
After months of buildup, it’s finally real! 🎉 The Evolutionary Systems Biophysics Group (ESBG) is officially alive at @bsc-cns.bsky.social . Proud to start this new adventure as a Ramon y Cajal Junior Group Leader🧬
Thanks to all who have been part of this process!
tinyurl.com/4r9vf4zx
Thanks to all who have been part of this process!
tinyurl.com/4r9vf4zx
October 2, 2025 at 8:06 AM
After months of buildup, it’s finally real! 🎉 The Evolutionary Systems Biophysics Group (ESBG) is officially alive at @bsc-cns.bsky.social . Proud to start this new adventure as a Ramon y Cajal Junior Group Leader🧬
Thanks to all who have been part of this process!
tinyurl.com/4r9vf4zx
Thanks to all who have been part of this process!
tinyurl.com/4r9vf4zx
CATH turns 30 years old 🥳
They celebrate with a Symposium on September 16th! I'll be presenting our work: "An Atlas of Energetic Evolutionary Constraints Across Protein Families"
Unbelievable selection of speakers! So if you are around London, you can register to attend:
tinyurl.com/2pnk8hj5
They celebrate with a Symposium on September 16th! I'll be presenting our work: "An Atlas of Energetic Evolutionary Constraints Across Protein Families"
Unbelievable selection of speakers! So if you are around London, you can register to attend:
tinyurl.com/2pnk8hj5
August 23, 2025 at 3:08 PM
CATH turns 30 years old 🥳
They celebrate with a Symposium on September 16th! I'll be presenting our work: "An Atlas of Energetic Evolutionary Constraints Across Protein Families"
Unbelievable selection of speakers! So if you are around London, you can register to attend:
tinyurl.com/2pnk8hj5
They celebrate with a Symposium on September 16th! I'll be presenting our work: "An Atlas of Energetic Evolutionary Constraints Across Protein Families"
Unbelievable selection of speakers! So if you are around London, you can register to attend:
tinyurl.com/2pnk8hj5
Finally online: my 1st current opinion article & my 1st article with only 2 authors, small dreams I had since my PhD student years! I hope you enjoy reading it! "Frustration, dynamics, and catalysis" together with my mentor Diego Ferreiro ⭐️
link:
t.co/q0K2g61F13
link:
t.co/q0K2g61F13
August 5, 2025 at 9:15 AM
Finally online: my 1st current opinion article & my 1st article with only 2 authors, small dreams I had since my PhD student years! I hope you enjoy reading it! "Frustration, dynamics, and catalysis" together with my mentor Diego Ferreiro ⭐️
link:
t.co/q0K2g61F13
link:
t.co/q0K2g61F13
Happy that our proposal "MEGA-scale Frustration Analysis of the Protein Universe: Evolution, Dynamics, and SNV Impact (MEGAFrustratEDS)" got selected to be funded by @ageinves.bsky.social! This is the 1st research grant to fund my team at @bsc-cns.bsky.social as a Ramon y Cajal Researcher! Thankful⭐️
July 29, 2025 at 4:19 PM
Happy that our proposal "MEGA-scale Frustration Analysis of the Protein Universe: Evolution, Dynamics, and SNV Impact (MEGAFrustratEDS)" got selected to be funded by @ageinves.bsky.social! This is the 1st research grant to fund my team at @bsc-cns.bsky.social as a Ramon y Cajal Researcher! Thankful⭐️
1 week away to go to Liverpool to one more
@iscb.bsky.social #ISMB2025! It's my favourite event of the year!
Happy to chair @3dsig.bsky.social and the #LGBTQIA+ meet up!
Looking forward to meet all the friends and colleagues! Let's organisé for coffees & dinners! ⭐️🎶🤝
@iscb.bsky.social #ISMB2025! It's my favourite event of the year!
Happy to chair @3dsig.bsky.social and the #LGBTQIA+ meet up!
Looking forward to meet all the friends and colleagues! Let's organisé for coffees & dinners! ⭐️🎶🤝
July 11, 2025 at 7:06 AM
1 week away to go to Liverpool to one more
@iscb.bsky.social #ISMB2025! It's my favourite event of the year!
Happy to chair @3dsig.bsky.social and the #LGBTQIA+ meet up!
Looking forward to meet all the friends and colleagues! Let's organisé for coffees & dinners! ⭐️🎶🤝
@iscb.bsky.social #ISMB2025! It's my favourite event of the year!
Happy to chair @3dsig.bsky.social and the #LGBTQIA+ meet up!
Looking forward to meet all the friends and colleagues! Let's organisé for coffees & dinners! ⭐️🎶🤝
7/8
We give our perspective in aspects such as:
*How distal mutations affect activity via dynamics
*How frustration affects motions in different timescales (µs–ms)
*ProteinMPNN, frustration and function
We give our perspective in aspects such as:
*How distal mutations affect activity via dynamics
*How frustration affects motions in different timescales (µs–ms)
*ProteinMPNN, frustration and function
July 9, 2025 at 9:17 AM
7/8
We give our perspective in aspects such as:
*How distal mutations affect activity via dynamics
*How frustration affects motions in different timescales (µs–ms)
*ProteinMPNN, frustration and function
We give our perspective in aspects such as:
*How distal mutations affect activity via dynamics
*How frustration affects motions in different timescales (µs–ms)
*ProteinMPNN, frustration and function
5/8
⚖️ Fig 2: Proteins evolved a “just right” frustration level
Enzyme catalysis involves transitions between internal and external states.
Too little frustration = motions freeze ❄️
Too much = chaos 🌪️
Just right = productive conformational transitions (FIMs) for catalysis 🧬
⚖️ Fig 2: Proteins evolved a “just right” frustration level
Enzyme catalysis involves transitions between internal and external states.
Too little frustration = motions freeze ❄️
Too much = chaos 🌪️
Just right = productive conformational transitions (FIMs) for catalysis 🧬
July 9, 2025 at 9:17 AM
5/8
⚖️ Fig 2: Proteins evolved a “just right” frustration level
Enzyme catalysis involves transitions between internal and external states.
Too little frustration = motions freeze ❄️
Too much = chaos 🌪️
Just right = productive conformational transitions (FIMs) for catalysis 🧬
⚖️ Fig 2: Proteins evolved a “just right” frustration level
Enzyme catalysis involves transitions between internal and external states.
Too little frustration = motions freeze ❄️
Too much = chaos 🌪️
Just right = productive conformational transitions (FIMs) for catalysis 🧬
4/8
📊 Fig 1: Frustration in dynamic energy landscapes
A: the dynamic energy funnel, proteins fold into a low-energy native ensemble, but local frustration adds ruggedness.
B: how this frustration enables FIMs to link conformational substates (CS) across the catalytic cycle.
📊 Fig 1: Frustration in dynamic energy landscapes
A: the dynamic energy funnel, proteins fold into a low-energy native ensemble, but local frustration adds ruggedness.
B: how this frustration enables FIMs to link conformational substates (CS) across the catalytic cycle.
July 9, 2025 at 9:17 AM
4/8
📊 Fig 1: Frustration in dynamic energy landscapes
A: the dynamic energy funnel, proteins fold into a low-energy native ensemble, but local frustration adds ruggedness.
B: how this frustration enables FIMs to link conformational substates (CS) across the catalytic cycle.
📊 Fig 1: Frustration in dynamic energy landscapes
A: the dynamic energy funnel, proteins fold into a low-energy native ensemble, but local frustration adds ruggedness.
B: how this frustration enables FIMs to link conformational substates (CS) across the catalytic cycle.
3/8
🧠 What is local frustration?
It’s when some interactions in a folded structure are energetically "suboptimal", leading to competing conformations (Conformational Substates or CS).
These CS enable functionally important motions (FIMs) needed for catalysis.
🧠 What is local frustration?
It’s when some interactions in a folded structure are energetically "suboptimal", leading to competing conformations (Conformational Substates or CS).
These CS enable functionally important motions (FIMs) needed for catalysis.
July 9, 2025 at 9:17 AM
3/8
🧠 What is local frustration?
It’s when some interactions in a folded structure are energetically "suboptimal", leading to competing conformations (Conformational Substates or CS).
These CS enable functionally important motions (FIMs) needed for catalysis.
🧠 What is local frustration?
It’s when some interactions in a folded structure are energetically "suboptimal", leading to competing conformations (Conformational Substates or CS).
These CS enable functionally important motions (FIMs) needed for catalysis.
🚨We've updated our preprint "Frustration, Dynamics, and Catalysis" ✨ We appreciate RT ☺️
A short 🧵1/8: We expanded the conceptual connection between the energy landscapes theory and catalysis, added new figures, and clarified how local frustration shapes enzyme function.
arxiv.org/pdf/2505.00600
A short 🧵1/8: We expanded the conceptual connection between the energy landscapes theory and catalysis, added new figures, and clarified how local frustration shapes enzyme function.
arxiv.org/pdf/2505.00600
July 9, 2025 at 9:17 AM
🚨We've updated our preprint "Frustration, Dynamics, and Catalysis" ✨ We appreciate RT ☺️
A short 🧵1/8: We expanded the conceptual connection between the energy landscapes theory and catalysis, added new figures, and clarified how local frustration shapes enzyme function.
arxiv.org/pdf/2505.00600
A short 🧵1/8: We expanded the conceptual connection between the energy landscapes theory and catalysis, added new figures, and clarified how local frustration shapes enzyme function.
arxiv.org/pdf/2505.00600
Our FrustraEvo web server has been relocated from Buenos Aires to Barcelona! We have fixed several issues and the resource should be more stable now! Looking forward to see how people use it :)
frustraevo.bsc.es
doi.org/10.1093/nar/...
frustraevo.bsc.es
doi.org/10.1093/nar/...
May 13, 2025 at 12:27 PM
Our FrustraEvo web server has been relocated from Buenos Aires to Barcelona! We have fixed several issues and the resource should be more stable now! Looking forward to see how people use it :)
frustraevo.bsc.es
doi.org/10.1093/nar/...
frustraevo.bsc.es
doi.org/10.1093/nar/...
We are extremely happy to host Dr. @joanampereira.bsky.social from VIB AI next May 29th for a Severo Ochoa seminar at @bsc-cns.bsky.social!
"AI-Driven Insights into Novel Families and Functions Across the Protein Universe"
You can attend online by registering here:
tinyurl.com/ywuepw9r
"AI-Driven Insights into Novel Families and Functions Across the Protein Universe"
You can attend online by registering here:
tinyurl.com/ywuepw9r
May 13, 2025 at 8:34 AM
We are extremely happy to host Dr. @joanampereira.bsky.social from VIB AI next May 29th for a Severo Ochoa seminar at @bsc-cns.bsky.social!
"AI-Driven Insights into Novel Families and Functions Across the Protein Universe"
You can attend online by registering here:
tinyurl.com/ywuepw9r
"AI-Driven Insights into Novel Families and Functions Across the Protein Universe"
You can attend online by registering here:
tinyurl.com/ywuepw9r
Our reviewers finished the selection of talks for this year's @3DSIG_ISCB @ ISMB! We had more excellent abstracts than we could accept! Notification have been sent to all authors! Check your emails!
We have a great programme ahead! Congratulations to the selected authors!
We have a great programme ahead! Congratulations to the selected authors!
May 13, 2025 at 6:49 AM
Our reviewers finished the selection of talks for this year's @3DSIG_ISCB @ ISMB! We had more excellent abstracts than we could accept! Notification have been sent to all authors! Check your emails!
We have a great programme ahead! Congratulations to the selected authors!
We have a great programme ahead! Congratulations to the selected authors!
Excited to share our opinion preprint article: "Frustration, dynamics and catalysis" where we discuss the rol of local frustration in how enzymes work to transform substrates into products
It was a pleasure, like always, to work with Prof. Diego Ferreiro on this!
arxiv.org/abs/2505.00600
It was a pleasure, like always, to work with Prof. Diego Ferreiro on this!
arxiv.org/abs/2505.00600
May 2, 2025 at 11:50 AM
Excited to share our opinion preprint article: "Frustration, dynamics and catalysis" where we discuss the rol of local frustration in how enzymes work to transform substrates into products
It was a pleasure, like always, to work with Prof. Diego Ferreiro on this!
arxiv.org/abs/2505.00600
It was a pleasure, like always, to work with Prof. Diego Ferreiro on this!
arxiv.org/abs/2505.00600
Our latest review is finally online in the Molecular Aspects of Medicine journal!
tinyurl.com/49kh9wzy
We have reviewed almost 2 decades of research in local frustration applied to proteins and also give new perspectives to be applied in other realms such as the brain! ⭐️🧑🔬
tinyurl.com/49kh9wzy
We have reviewed almost 2 decades of research in local frustration applied to proteins and also give new perspectives to be applied in other realms such as the brain! ⭐️🧑🔬
April 24, 2025 at 3:18 AM
Our latest review is finally online in the Molecular Aspects of Medicine journal!
tinyurl.com/49kh9wzy
We have reviewed almost 2 decades of research in local frustration applied to proteins and also give new perspectives to be applied in other realms such as the brain! ⭐️🧑🔬
tinyurl.com/49kh9wzy
We have reviewed almost 2 decades of research in local frustration applied to proteins and also give new perspectives to be applied in other realms such as the brain! ⭐️🧑🔬
We are moving at full speed towards a great meeting this year!
This year's programme will look fabulous! You can still be part of it!! There is still one more week to go to send your work to this year's 3DSIG!! Do not miss the chance!!!
Check our great keynotes!
Submit now!
t.co/gCPpDtpzD8
This year's programme will look fabulous! You can still be part of it!! There is still one more week to go to send your work to this year's 3DSIG!! Do not miss the chance!!!
Check our great keynotes!
Submit now!
t.co/gCPpDtpzD8
April 10, 2025 at 4:58 PM
We are moving at full speed towards a great meeting this year!
This year's programme will look fabulous! You can still be part of it!! There is still one more week to go to send your work to this year's 3DSIG!! Do not miss the chance!!!
Check our great keynotes!
Submit now!
t.co/gCPpDtpzD8
This year's programme will look fabulous! You can still be part of it!! There is still one more week to go to send your work to this year's 3DSIG!! Do not miss the chance!!!
Check our great keynotes!
Submit now!
t.co/gCPpDtpzD8
We are getting so many great abstracts!! This year's programme will look fabulous! You can still be part of it!! There is still one more week to go to send your work to this year's 3DSIG!! Do not miss the chance!!!
Submit now!
t.co/gCPpDtpzD8
Submit now!
t.co/gCPpDtpzD8
April 9, 2025 at 8:25 AM
We are getting so many great abstracts!! This year's programme will look fabulous! You can still be part of it!! There is still one more week to go to send your work to this year's 3DSIG!! Do not miss the chance!!!
Submit now!
t.co/gCPpDtpzD8
Submit now!
t.co/gCPpDtpzD8
Everything comes to an end but memories remain!!
We had a great 3DSIG/3DBioinfo event in "sunny" Barcelona this week!! I have enjoyed so much to help organising it & to have such great minds all together sharing science for 3 days!!
Aufwiedersehen friends! For more science & friendships to come! ⭐
We had a great 3DSIG/3DBioinfo event in "sunny" Barcelona this week!! I have enjoyed so much to help organising it & to have such great minds all together sharing science for 3 days!!
Aufwiedersehen friends! For more science & friendships to come! ⭐
March 22, 2025 at 1:45 PM
Everything comes to an end but memories remain!!
We had a great 3DSIG/3DBioinfo event in "sunny" Barcelona this week!! I have enjoyed so much to help organising it & to have such great minds all together sharing science for 3 days!!
Aufwiedersehen friends! For more science & friendships to come! ⭐
We had a great 3DSIG/3DBioinfo event in "sunny" Barcelona this week!! I have enjoyed so much to help organising it & to have such great minds all together sharing science for 3 days!!
Aufwiedersehen friends! For more science & friendships to come! ⭐
Great thoughts by Prof. Yves Moreau! We, academics, have the moral duty to resist & to keep speaking up against the totalitarian technocracy that is proposed by these billionaires ✊
www.linkedin.com/pulse/our-st...
www.linkedin.com/pulse/our-st...
March 22, 2025 at 1:44 PM
Great thoughts by Prof. Yves Moreau! We, academics, have the moral duty to resist & to keep speaking up against the totalitarian technocracy that is proposed by these billionaires ✊
www.linkedin.com/pulse/our-st...
www.linkedin.com/pulse/our-st...
I cannot wait to this event to happen! We will have 3 days of great scientific discussions, planning for collaborators and networking with old friends and new colleagues!
Programme:
iscb.org/3dbioinfo202...
You can still register:
iscb.org/3dbioinfo202...
Programme:
iscb.org/3dbioinfo202...
You can still register:
iscb.org/3dbioinfo202...
February 19, 2025 at 7:27 PM
I cannot wait to this event to happen! We will have 3 days of great scientific discussions, planning for collaborators and networking with old friends and new colleagues!
Programme:
iscb.org/3dbioinfo202...
You can still register:
iscb.org/3dbioinfo202...
Programme:
iscb.org/3dbioinfo202...
You can still register:
iscb.org/3dbioinfo202...
Just 1.5 months away from our joint 3DBioinfo/3DSIG amazing conference!
These are two of our great invited speakers!
Gemma Atkinson and Isaure Chauvot de Beauchene!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...
These are two of our great invited speakers!
Gemma Atkinson and Isaure Chauvot de Beauchene!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...
February 15, 2025 at 10:50 AM
Just 1.5 months away from our joint 3DBioinfo/3DSIG amazing conference!
These are two of our great invited speakers!
Gemma Atkinson and Isaure Chauvot de Beauchene!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...
These are two of our great invited speakers!
Gemma Atkinson and Isaure Chauvot de Beauchene!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...
Check some of our invited speakers!!! @ptck72.bsky.social and Silvio Tosatto!
Register to the conference:
iscb.org/3dbioinfo202...
Register to the conference:
iscb.org/3dbioinfo202...
February 14, 2025 at 10:14 AM
Check some of our invited speakers!!! @ptck72.bsky.social and Silvio Tosatto!
Register to the conference:
iscb.org/3dbioinfo202...
Register to the conference:
iscb.org/3dbioinfo202...
RT please: Just 1.5 months away from our joint 3DBioinfo/3DSIG amazing conference!
These are our two great keynote speakers!
@rolanddunbrack.bsky.social & @silviaosuna.bsky.social!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...
These are our two great keynote speakers!
@rolanddunbrack.bsky.social & @silviaosuna.bsky.social!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...
February 13, 2025 at 10:41 AM
RT please: Just 1.5 months away from our joint 3DBioinfo/3DSIG amazing conference!
These are our two great keynote speakers!
@rolanddunbrack.bsky.social & @silviaosuna.bsky.social!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...
These are our two great keynote speakers!
@rolanddunbrack.bsky.social & @silviaosuna.bsky.social!
Check our preliminary programme here:
www.iscb.org/3dbioinfo202...
Registration link:
www.iscb.org/3dbioinfo202...