Gladfelter Lab
@gladfelterlab.bsky.social
Scientists using microscopes, math, physics and fun to discover how cells work @Duke Cell Biology/BME. https://gladfelterlab.net
Delighted to share the latest chapter in the mystery series on how septins sense membrane curvature. Grateful to reviewers for thoughtful critiques and @jcb.org for publishing our work! doi.org/10.1083/jcb....
Lipid packing and local geometry influence septin curvature sensing
Localization of the septin cytoskeleton is controlled by regulatory factors, membrane curvature, and charge. In this study, changes to lipid composition th
doi.org
November 4, 2025 at 4:13 AM
Delighted to share the latest chapter in the mystery series on how septins sense membrane curvature. Grateful to reviewers for thoughtful critiques and @jcb.org for publishing our work! doi.org/10.1083/jcb....
Our paper on the spatial organization of nuclear paraspeckles is out in #PNAS! Excited to see what comes next from the teams of @shrinivaslab.bsky.social and @sneadlab.bsky.social at Northwestern! pnas.org/doi/10.1073/pnas.2504778122
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
August 7, 2025 at 4:10 PM
Our paper on the spatial organization of nuclear paraspeckles is out in #PNAS! Excited to see what comes next from the teams of @shrinivaslab.bsky.social and @sneadlab.bsky.social at Northwestern! pnas.org/doi/10.1073/pnas.2504778122
Reposted by Gladfelter Lab
We are back! 🔬👩🔬👨🔬
Mark your calendars, TCM 2025 is happening September 15th at the Trent Semans Center! 🧠✨
Get ready for an incredible lineup of speakers including Dr. Kris DeMali, Dr. Rae Cho, and Dr. Stefanie Redemann.
🗓️ Registration opens July 7th, don’t miss out!
#TCM2025
Mark your calendars, TCM 2025 is happening September 15th at the Trent Semans Center! 🧠✨
Get ready for an incredible lineup of speakers including Dr. Kris DeMali, Dr. Rae Cho, and Dr. Stefanie Redemann.
🗓️ Registration opens July 7th, don’t miss out!
#TCM2025
June 13, 2025 at 1:31 AM
We are back! 🔬👩🔬👨🔬
Mark your calendars, TCM 2025 is happening September 15th at the Trent Semans Center! 🧠✨
Get ready for an incredible lineup of speakers including Dr. Kris DeMali, Dr. Rae Cho, and Dr. Stefanie Redemann.
🗓️ Registration opens July 7th, don’t miss out!
#TCM2025
Mark your calendars, TCM 2025 is happening September 15th at the Trent Semans Center! 🧠✨
Get ready for an incredible lineup of speakers including Dr. Kris DeMali, Dr. Rae Cho, and Dr. Stefanie Redemann.
🗓️ Registration opens July 7th, don’t miss out!
#TCM2025
Discover the wonder of the fungi in this latest issue of Current Biology 🍄 www.cell.com/curbio/issue...
Current issue: Current Biology
www.cell.com
June 9, 2025 at 4:26 PM
Discover the wonder of the fungi in this latest issue of Current Biology 🍄 www.cell.com/curbio/issue...
Reposted by Gladfelter Lab
Start of 2025 @mblscience.bsky.social Physiology course! This is the second year of Amy @gladfelterlab.bsky.social and I co-Directing this absolutely amazing and life-changing course: www.mbl.edu/education/ad...
June 9, 2025 at 3:03 PM
Start of 2025 @mblscience.bsky.social Physiology course! This is the second year of Amy @gladfelterlab.bsky.social and I co-Directing this absolutely amazing and life-changing course: www.mbl.edu/education/ad...
Amazing start to EMBO workshop Cells4Climate resilience>>https://meetings.embo.org/event/25-climate-resilience>>day 1 energy captured here youtu.be/KFRFSPHdjFM
youtu.be
April 15, 2025 at 8:27 AM
Amazing start to EMBO workshop Cells4Climate resilience>>https://meetings.embo.org/event/25-climate-resilience>>day 1 energy captured here youtu.be/KFRFSPHdjFM
🌍🔬 📣 Please spread the word! Join us!
How can cell biology shape a more resilient planet?
Virtual registration is still open for the EMBO Workshop on Cells 4 Climate Resilience → meetings.embo.org/event/25-cli...
🗓️ Deadline: April 11
🎥 Watch the teaser → youtu.be/8eMJ91udHDs
@embo.org
How can cell biology shape a more resilient planet?
Virtual registration is still open for the EMBO Workshop on Cells 4 Climate Resilience → meetings.embo.org/event/25-cli...
🗓️ Deadline: April 11
🎥 Watch the teaser → youtu.be/8eMJ91udHDs
@embo.org
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meetings.embo.org
April 6, 2025 at 9:42 PM
🌍🔬 📣 Please spread the word! Join us!
How can cell biology shape a more resilient planet?
Virtual registration is still open for the EMBO Workshop on Cells 4 Climate Resilience → meetings.embo.org/event/25-cli...
🗓️ Deadline: April 11
🎥 Watch the teaser → youtu.be/8eMJ91udHDs
@embo.org
How can cell biology shape a more resilient planet?
Virtual registration is still open for the EMBO Workshop on Cells 4 Climate Resilience → meetings.embo.org/event/25-cli...
🗓️ Deadline: April 11
🎥 Watch the teaser → youtu.be/8eMJ91udHDs
@embo.org
What a wonderful time catching us with @meghanriddell.bsky.social in Charolette at the Society for Reproductive Investigation Annual Meeting!
March 28, 2025 at 10:15 PM
What a wonderful time catching us with @meghanriddell.bsky.social in Charolette at the Society for Reproductive Investigation Annual Meeting!
Reposted by Gladfelter Lab
Mónica Bettencourt-Dias @monicabettencourt.bsky.social, Amy Gladfelter @gladfelterlab.bsky.social, Gautam Dey @gautamdey.bsky.social Samara Reck-Peterson @samreckpeterson.bsky.social @cells4planethealth.bsky.social @embo.org share a call to action to apply the lens of #cellbio to climate challenges.
Cell biology meets climate resilience – a call to action
The molecular and cellular biology community has always been driven by a fascination with mechanisms – how proteins interact, how organelles communicate and how cells respond to stimuli. Yet one of th...
journals.biologists.com
March 25, 2025 at 9:22 AM
Mónica Bettencourt-Dias @monicabettencourt.bsky.social, Amy Gladfelter @gladfelterlab.bsky.social, Gautam Dey @gautamdey.bsky.social Samara Reck-Peterson @samreckpeterson.bsky.social @cells4planethealth.bsky.social @embo.org share a call to action to apply the lens of #cellbio to climate challenges.
Excited to share our first story on nuclear paraspeckles! Led by @sneadlab.bsky.social, this is the culmination of a ~4 year effort in collab. with @shrinivaslab.bsky.social. Can’t wait to see more paraspeckle stories from the future Snead Lab at Northwestern 🫧 www.biorxiv.org/content/10.1...
Immiscible proteins compete for RNA binding to order condensate layers
Biomolecular condensates mediate diverse and essential cellular functions by compartmentalizing biochemical pathways. Many condensates have internal subdomains with distinct compositional identities. ...
www.biorxiv.org
March 19, 2025 at 7:09 PM
Excited to share our first story on nuclear paraspeckles! Led by @sneadlab.bsky.social, this is the culmination of a ~4 year effort in collab. with @shrinivaslab.bsky.social. Can’t wait to see more paraspeckle stories from the future Snead Lab at Northwestern 🫧 www.biorxiv.org/content/10.1...
The mysteries of septins continue to unfold in this study examining mechanisms of septin polymerization and assembly! www.biorxiv.org/content/10.1...
Cooperativity in septin polymerization is tunable by ionic strength and membrane adsorption
Cells employ cytoskeletal polymers to move, divide, and pass information inside and outside of the cell. Previous work on eukaryotic cytoskeletal elements such as actin, microtubules, and intermediate...
www.biorxiv.org
February 18, 2025 at 10:46 PM
The mysteries of septins continue to unfold in this study examining mechanisms of septin polymerization and assembly! www.biorxiv.org/content/10.1...
We are excited to share our next installment of insights into how septins sense micron-scale curvature via detecting lipid packing! www.biorxiv.org/content/10.1...
Lipid packing and local geometry influence septin curvature sensing
Septins assemble into scaffolds that direct cell growth and morphology that are often localized to the plasma membrane. While septins preferentially bind convex membranes via amphipathic helices, thei...
www.biorxiv.org
February 18, 2025 at 10:23 PM
We are excited to share our next installment of insights into how septins sense micron-scale curvature via detecting lipid packing! www.biorxiv.org/content/10.1...
Change your life! Physiology course application deadline is extended to February 3rd! Apply now for a summer of discovery at MBL!
🗣️ Physiologists, rejoice! Thought you missed the deadline for the 2025 Physiology course at MBL? Don't toss out that application draft—you can now apply through February 3.
Read more: bit.ly/3BZSj9c
#ScienceStartsHere
Read more: bit.ly/3BZSj9c
#ScienceStartsHere
January 29, 2025 at 2:27 PM
Change your life! Physiology course application deadline is extended to February 3rd! Apply now for a summer of discovery at MBL!
The deadline for @cells4planethealth.bsky.social has been extended to February 1st- register now! meetings.embo.org/event/25-cli...
Integrating cell and planetary scales to address climate resilience
The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…
meetings.embo.org
January 19, 2025 at 8:20 PM
The deadline for @cells4planethealth.bsky.social has been extended to February 1st- register now! meetings.embo.org/event/25-cli...
The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...
Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches | Marine Biological Laboratory
This course is at the forefront of new tools — molecular, computational, biophysical — as it prepares students to tackle emerging biological questions.
www.mbl.edu
January 19, 2025 at 8:17 PM
The deadline to apply for the MBL Physiology course is fast approaching, January 27th! Consider applying to this amazing, life-changing research discovery experience in Woods Hole! www.mbl.edu/education/ad...
Reposted by Gladfelter Lab
📢 Dive into topics like cell biology in changing environments, microbial ecology, and climate adaptation strategies for planet and human health at the EMBO Workshop in Lisbon! 🌱
🗓️ April 13–16, 2025 | Lisbon, Portugal
Secure your spot: meetings.embo.org/event/25-cli...
#CellBiology #PlanetaryHealth
🗓️ April 13–16, 2025 | Lisbon, Portugal
Secure your spot: meetings.embo.org/event/25-cli...
#CellBiology #PlanetaryHealth
Integrating cell and planetary scales to address climate resilience
The climate crisis is a multiscale problem that requires transdisciplinary expertise for understanding and engineering climate resilience. Cells are the first responders of the biosphere and yet cell…
meetings.embo.org
January 8, 2025 at 11:52 AM
📢 Dive into topics like cell biology in changing environments, microbial ecology, and climate adaptation strategies for planet and human health at the EMBO Workshop in Lisbon! 🌱
🗓️ April 13–16, 2025 | Lisbon, Portugal
Secure your spot: meetings.embo.org/event/25-cli...
#CellBiology #PlanetaryHealth
🗓️ April 13–16, 2025 | Lisbon, Portugal
Secure your spot: meetings.embo.org/event/25-cli...
#CellBiology #PlanetaryHealth
Two weeks left to apply for this year's Physiology Course! We are looking forward to another exciting summer 🔬🦑☀️
🔔Upcoming deadline!🔔
January 27 is the last day to submit applications to the MBL's 2025 Physiology Course. This seven-week lab course has educated generations of leading biologists and fostered groundbreaking discoveries.
Learn more: bit.ly/3BZSj9c
#ScienceStartsHere
January 27 is the last day to submit applications to the MBL's 2025 Physiology Course. This seven-week lab course has educated generations of leading biologists and fostered groundbreaking discoveries.
Learn more: bit.ly/3BZSj9c
#ScienceStartsHere
January 13, 2025 at 9:04 PM
Two weeks left to apply for this year's Physiology Course! We are looking forward to another exciting summer 🔬🦑☀️
New work lead by graduate student Alex shows how concerned signaling networks can be modulated for distinct morphogenic programs even within the constraints of fungal budding! www.biorxiv.org/content/10.1...
Negative feedback equalizes polarity sites in a multi-budding yeast
Morphogenesis in fungi and animals is directed by polarization of small GTPases Cdc42 and Rac. In the budding yeast Saccharomyces cerevisiae competition between polarity patches results in one polariz...
www.biorxiv.org
January 8, 2025 at 10:10 PM
New work lead by graduate student Alex shows how concerned signaling networks can be modulated for distinct morphogenic programs even within the constraints of fungal budding! www.biorxiv.org/content/10.1...
Thrilled to share our recent work on the power of RNA to encode physical information and how this can be embedded in the genetic code
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
RNA encodes physical information
Most amino acids are encoded by multiple codons, making the genetic code degenerate. Synonymous mutations affect protein translation and folding, but their impact on RNA itself is often neglected. We ...
www.biorxiv.org
January 8, 2025 at 8:57 PM
Thrilled to share our recent work on the power of RNA to encode physical information and how this can be embedded in the genetic code
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Excited to share the latest work from postdocs Ameya
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...
Condensates act as translation hubs to coordinate multinucleate cell growth
Coordination between growth and division is a fundamental feature of cells. In many syncytia, cell growth must couple with multiple nuclear divisions in one cytoplasm. In the fungus, Ashbya gossypii, ...
www.biorxiv.org
January 8, 2025 at 8:53 PM
Excited to share the latest work from postdocs Ameya
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...
and Zach! We thought about how multinucleate cells are able to maintain N:C ratio, and found a condensate rheostat that regulates translation of cell cycle + growth mRNAs. Check it out! www.biorxiv.org/content/10.1...