André C. Müller Chengzhe Tian Abigail Jarret Julio Garcia Daniela Reil Diana Santacruz Mary Piotrowski Stephen Noell Christoph Bueschl Huanyu Li @Smereiter Tiago Oliveira Josef (Joe!) M. Penninger @penningerlab.bsky.social @davidbsauer.bsky.social Claire M. Steppan Coralie Viollet Kristap Klavins

@rebsamenlab.bsky.social‬ Sabrina Lindinger Iciar Serrano Christoph Klimek Barbara Barbosa Anastasiia Pantielieieva @vojtechdvorak.bsky.social J. Thomas Hannich Julian Schoenbett Gilles Sansig Tamara A.M. Mocking Jasper F. Ooms Adriaan P. IJzerman Laura Heitman Peter Sykacek Juergen Reinhardt

Mariah Kohlbrenner Lena Chang Paul Selzer Jürgen Reinhardt Daniela Digles @gerhardecker.bsky.social Tanja Osthushenrich Aidan MacNamara @j-anders.bsky.social David Hepworth Svenja Onstein Enrico Girardi Rene Ladurner Eva Lineiro-Retes Zuzana Gelova Brianda L Santini @annkatrinhopp.bsky.social

Thank you to the authors: Ulrich Goldmann Tabea Wiedmer Andrea Garofoli Vitaly Sedlyarov Manuel Bichler @gernot-wolf.bsky.social Eirini Christodoulaki Alvaro Ingles Prieto Evandro Ferrada @fabianfrommelt.bsky.social Shao Teoh Thing @pleippe.bsky.social Ben Haladik Gabriel Onea Martin Pfeifer

Thank you to all partners, including @cemm-vienna.bsky.social @meduniwien.ac.at @oeaw.bsky.social @novartis.bsky.social‬ @univie.ac.at e.ac.at‬ Bayer Pfizer @boehringerglobal.bsky.social @cmd.ox.ac.uk @ndm.ox.ac.uk

All reagents, tools, and datasets from the RESOLUTE project are openly available at re-solute.eu, promoting open science and facilitating research efforts on #TransporterProteins worldwide. Funded by @ihieurope.bsky.social, the EU, EFPIA and the @oeaw.bsky.social

We integrated RESOLUTE data with public datasets to build a comprehensive, open-access #SoluteCarrier resource—systematically mapping their biochemical functions and biological roles. A blueprint for extracting insights from complex multi-omics data doi.org/10.1038/s443...

Over 35,000 double knockouts revealed synthetic lethal pairs and redundancies, highlighting therapeutic targets—especially in mitochondrial #SLCs. SLC39A1, a zinc #transporter, surprisingly drives metabolic rewiring and anti-apoptotic signaling in cancer. doi.org/10.1038/s443...

Highlights include #PDZ-domain roles in trafficking and degrons in stability—uncovering how #SLCs are controlled post-translationally. doi.org/10.1038/s443...

In the global survey of the SLC-protein interaction landscape we determined the protein interactions of ~400 #SLCs revealing thousands of new links.

Clustering and integration of metabolomics and transcriptomics profiles of all #SLCs enabled the linkage of #SLCs to new metabolic pathways. Further experimental validation uncovered roles in osmolyte balance and glycosylation doi.org/10.1038/s443...

Hundreds of genetically modified cell lines covering the entire #SLC superfamily were generated for systematic omics studies. By measuring metabolomics, we revealed functions for 71 unknown transporters. Among them, #SLC45A4 was found to transport polyamines

The RESOLUTE megaproject was executed by 120 researchers from 13 institutions across eight countries. We are grateful to a wonderful community that formed over more than five years. Together we paved the way for accelerated therapeutic innovation for #SoluteCarriers

but these posts are frustrating...why don't you tell us the cause?