Gian Marco Duma
gianmarcoduma.bsky.social
Gian Marco Duma
@gianmarcoduma.bsky.social
Finally out our new work in which we showed a global dynamic shift towards inhibition as a potential protective mechanism before seizure onset, and it relationship with cortical thickness and muscarinic receptor density.

link.springer.com/article/10.1...
Dynamic excitation/inhibition balance preceding seizure onset and its link to functional and structural brain architecture - BMC Medicine
Background Altered excitation/inhibition (E/I) balance is a key mechanism in epilepsy, but its dynamic changes before seizure onset remain unclear. The interictal suppression hypothesis suggests that ...
link.springer.com
November 3, 2025 at 2:49 PM
Reposted by Gian Marco Duma
On Tuesday, @martinasaltafossi.bsky.social will present her poster on respiration and E:I balance in temporal lobe epilepsy.
September 15, 2025 at 1:39 PM
Reposted by Gian Marco Duma
🧠 Join us for the Brain Models for Multimodal Integration Symposium!
📅 12 September 2025 | ⏰ 12:00–13:15 UTC | 🌐 Virtual Event

Thrilled to co-chair w/ @pierpasorre.bsky.social at the @ohbmofficial.bsky.social Satellite Meeting! Feat. D. Depannemaecker & @gianmarcoduma.bsky.social ma.bsky.social.
September 5, 2025 at 3:20 PM
Reposted by Gian Marco Duma
New paper🥳

🧠 In TLE, brain changes go beyond the temporal lobe & beyond normal aging.

Our ENIGMA study (769 patients, 18 sites) found widespread gray & white matter decline, especially after 55. By Judy Chen and a terrific intl' team

Time for earlier diagnosis & deeper research
bit.ly/3HRYeQt
August 24, 2025 at 6:05 PM
🚨Paper alert
Finally out this impressive piece of science in which we used Virtual Brain Twins to simulate intracranial and non-invasive(Temporal interfence) stimulation to estimate the epileptogenic zone!
Honored of being part of this stellar team!

www.nature.com/articles/s43...
Virtual brain twins for stimulation in epilepsy - Nature Computational Science
A high-resolution virtual brain twin approach is proposed using stimulation-induced seizures to estimate the epileptogenic network, offering a step toward non-invasive diagnosis and treatment of drug-...
www.nature.com
August 5, 2025 at 3:58 PM
Reposted by Gian Marco Duma
🧠 New Preprint out!
Brain fluidity: a functional marker of neuronal death in Alzheimer’s disease (AD).
Our results highlight the link between dynamic brain connectivity disruptions and neurodegeneration in AD.
@pierpasorre.bsky.social @gianmarcoduma.bsky.social www.medrxiv.org/content/10.1...
Brain Fluidity as a Functional Marker of Tau-Related Neurodegeneration in Alzheimer’s Disease
Alzheimer’s Disease (AD) is the most common form of dementia and one of the leading neurodegenerative disorders worldwide. Neurophysiopathologically, AD is characterized by neuronal death, accompanied...
www.medrxiv.org
July 23, 2025 at 10:34 AM
A great honor to have partecipated to the book

EEG: The First 100 Years
link.springer.com/book/10.1007...
edited by the incredible prof. Mecarelli and Dr. Brigo.

In the chapter we discussed advancements and future directions of EEG applications
Link to chapter:
link.springer.com/chapter/10.1...
https://link.springer.com/book/10.1007/9…
June 15, 2025 at 7:38 AM