Gc Rox
gcrox.bsky.social
Gc Rox
@gcrox.bsky.social
Hank Seifert is a Professor at Northwestern Medical School in Chicago. I'm interested in everything, particularly bacteria, but our group studies the Neisseria gonorrhoeae pilus—antigenic variation and functions.
Reposted by Gc Rox
Together with @soreklab.bsky.social, our labs discovered that the human cGAS-STING pathway evolved from ancient bacterial proteins in CBASS anti-phage defense

www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
STING cyclic dinucleotide sensing originated in bacteria - Nature
Structures of prokaryotic homologues of STING permit the reconstruction of the evolutionary trajectory of its incorporation into metazoan innate immunity, and reveal a role for the conserved cGAS–STIN...
www.nature.com
September 5, 2025 at 10:13 AM