🌍 Why it matters:

Our findings highlight how diet and gut microbiome (microbes, regional pH, metabolites) influence the host’s systemic immune regulation—with new connections and potential implications for chronic disease prevention

🔍 What we did:

We combined metagenomes, in vivo colonic pH, & deep peripheral immune phenotyping (121 cell types & subtypes) to uncover novel host–microbe interactions in humans - the most detailed map of microbiome interaction w the human systemic immune system to date

You can read more in our review published in Sept 25 in @natrevgastrohep.nature.com

www.nature.com/articles/s41...

💡 Take‑home: Maternal fibre intake during pregnancy is cardioprotective for offspring, but the effect may be exaggerated in males

@monashuniversity.bsky.social

🧫 Flow cytometry → sex‑specific changes in monocytes & lymphocytes

🧬 Single‑cell RNAseq → fibrotic genes reduced in both sexes, but inflammatory genes downregulated only in males

🦠 Microbiome → male offspring showed more changes than females

In our latest paper in Clinical Sciences, led by PhD student Chaoran Yang, we reveal that maternal fibre intake doesn’t affect male and female offspring equally 👇

🔗 portlandpress.com/clinsci/arti...

Last year, we published a study in Circulation Research showing that maternal fibre intake during pregnancy was cardioprotective for the offspring via gut microbial metabolites known as short-chain fatty acids (SCFAs)

www.ahajournals.org/doi/10.1161/...

Thank you Tatiane 🙏

Her PhD focuses on how the gut #microbiome and intestinal pH contribute to human physiology such as #bloodpressure and the #immunesystem

Her papers so far include:

pubmed.ncbi.nlm.nih.gov/40560060/

pubmed.ncbi.nlm.nih.gov/38899764/

One more submitted, 2 under preparation! Watch this space

There are guidelines for fibre intake (eg pubmed.ncbi.nlm.nih.gov/38586958/)

Yes the amounts of fibre are correct, the diets used in mice were extreme, reusing samples from a previous paper (pubmed.ncbi.nlm.nih.gov/32093510/) however we have data across several human populations

Look forward to continuing the conversations from Australia!

I’m off to UKE in Hamburg today and then the Max Planck Institute in Berlin on Tuesday

For now, safe travels everyone!