Fritz Roth
@fritzroth.bsky.social
Opinions here are my own.
Day job: Professor and Chair,
Computational & Systems Biology,
University of Pittsburgh School of Medicine
https://rothlab.csb.pitt.edu/
Systematically testing impacts of genetic change & mapping protein interaction dynamics
Day job: Professor and Chair,
Computational & Systems Biology,
University of Pittsburgh School of Medicine
https://rothlab.csb.pitt.edu/
Systematically testing impacts of genetic change & mapping protein interaction dynamics
Reposted by Fritz Roth
We highlight the power of iPSC-SGE by identifying sarcomere dependent variant effects of MYBPC3 in cardiomyocytes. Additionally, we identified dominant negative and LOF variant effects in POLG by assaying variants in multiple genetic backgrounds. Please see our preprint for more exciting results!
November 22, 2025 at 1:49 AM
We highlight the power of iPSC-SGE by identifying sarcomere dependent variant effects of MYBPC3 in cardiomyocytes. Additionally, we identified dominant negative and LOF variant effects in POLG by assaying variants in multiple genetic backgrounds. Please see our preprint for more exciting results!