Frédérique Le Roux
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fredoleroux.bsky.social
Frédérique Le Roux
@fredoleroux.bsky.social
Professeure/chaire d'excellence du Canada
Université de Montréal
Département de microbiologie, infectiologie et immunologie
What do I like? Wild things 😜 yet phages are my favorite!
Reposted by Frédérique Le Roux
Many thanks to all those involved, including Jeffrey Liang, who stayed in our lab for several months, our own Charles Bernard and, of course, @fredoleroux.bsky.social and the usual suspects @agencerecherche.bsky.social @erc.europa.eu @cnrsbiologie.bsky.social @pasteur.fr @umontreal.ca etc
October 14, 2025 at 4:08 PM
And thank you so much Pauline!!! It was very cool to see you again with other 'old' conference friends, looking forward to see you again @ Roscoff 2026/Monod conference/virus evolution ;-)?
August 22, 2025 at 2:10 PM
and here is the link for the program: event.fourwaves.com/fr/scm-csm20...
SCM-CSM2025 UMontreal Conference
Fourwaves - SCM-CSM2025 UMontreal Conference
event.fourwaves.com
June 9, 2025 at 5:31 PM
Reposted by Frédérique Le Roux
And I've written a few reviews on the subject over the years, but this one is pretty short, so why not start there ;)

www.sciencedirect.com/science/arti...
How clonal are bacteria over time?
Bacteria and archaea reproduce clonally (vertical descent), but exchange genes by recombination (horizontal transfer). Recombination allows adaptive m…
www.sciencedirect.com
May 29, 2025 at 6:58 PM
Congratulation Mélanie, so cool story on phage defense and pathogen evolution in real life!
May 23, 2025 at 11:12 AM
Reposted by Frédérique Le Roux
Have also a look at our back-to-back study for mobile integrons by Nicolas Kieffer from @jaescudero.bsky.social group !
www.science.org/doi/10.1126/...
+ a similar story in V. parahaemolyticus by @landongetz.bsky.social from @themaxwelllab.bsky.social
www.nature.com/articles/s41...
Mobile integrons encode phage defense systems
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle ...
www.science.org
May 9, 2025 at 11:41 AM
Reposted by Frédérique Le Roux
An enormous thanks for the great co-first author @eloilittner.bsky.social and for our supervisors @celineloot.bsky.social @epcrocha.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social. Many thanks to all co-authors !!
May 9, 2025 at 11:41 AM
Reposted by Frédérique Le Roux
On the bioinformatic side, eloilittner.bsky.social found a diverse arsenal of anti-phage defenses in SCIs. Strikingly, systems in integrons are always compact (< 3 genes), and smaller than their homologs outside integrons (likely due to cassette size constraints)
May 9, 2025 at 11:41 AM
Reposted by Frédérique Le Roux
The integron of our favorite model Vibrio cholerae was mostly “dark matter” as most cassettes had no known role. We found this intriguing and cloned 88 cassettes, testing them for phage resistance. We found 16 defensive cassettes and named the systems after gallic mythology
May 9, 2025 at 11:41 AM