Fitz-James Lab
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fitz-james-lab.bsky.social
Fitz-James Lab
@fitz-james-lab.bsky.social
Molecular biology lab based at the Department of Biology, University of Oxford. Researching insect epigenetics and epigenetic inheritance. Actively recruiting!
Would love to be added as well please!
July 30, 2025 at 2:25 AM
10/10 Very happy to have this paper out and for the wonderful work done with Peter and our students Poppy and Chris!
March 12, 2025 at 1:37 PM
9/10 While we can’t fully explain this effect, this downregulation of Pho, with potential downstream effects on Polycomb targets, may be something to keep in mind when using Sb as a marker in future.
March 12, 2025 at 1:37 PM
8/10 In following up on this unexpected result, we found that mutation of Sb has an effect on expression of Pho, a recruiter of the PRC2 complex responsible for depositing H3K27me3.
March 12, 2025 at 1:37 PM
7/10 As controls for our sRNA pathway mutants we used some well-known marker mutations on the same chromosome. One of these, mutation in the gene Stubble (Sb) which is well-known to Drosophila enthusiasts, had a clear effect on eye colour, making it more red.
March 12, 2025 at 1:36 PM
6/10 Next, we tested an array of mutants in sRNA pathways. Again, we found no effect of the mutations on eye colour, arguing against a role for sRNAs in eye colour. However, a surprising result involving one of our controls jumped out at us…
March 12, 2025 at 1:36 PM