Fany M. Real
@fany-real.bsky.social
Group leader at CABD (Seville). Previous at Max Planck Institute for Molecular Genetics (Berlin). Interested in evolutionary genomics of moles and in any other living creature!
Email: [email protected]
Web: https://fmreallab.github.io/website/
Email: [email protected]
Web: https://fmreallab.github.io/website/
Pinned
Fany M. Real
@fany-real.bsky.social
· Jul 17
Thrilled to see our revised preprint now published in Nature Ecology & Evolution!
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!
www.nature.com/articles/s41...
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!
www.nature.com/articles/s41...
Reposted by Fany M. Real
To celebrate the most recently attributed José Luis Gomez Skarmeta prize #JLGS2024 we interviewed the prize winner @dariloops.bsky.social @cabd-upo-csic.bsky.social on his research and his thoughts on #DevBio youtu.be/eldKr4MIrIU?...
Premio José Luis Gómez Skarmeta a la excelencia científica 2024 a Dario Lupiáñez García
YouTube video by Sociedad Española de Biología del Desarrollo
youtu.be
November 3, 2025 at 2:19 PM
To celebrate the most recently attributed José Luis Gomez Skarmeta prize #JLGS2024 we interviewed the prize winner @dariloops.bsky.social @cabd-upo-csic.bsky.social on his research and his thoughts on #DevBio youtu.be/eldKr4MIrIU?...
Reposted by Fany M. Real
📢 We are hiring!
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
October 15, 2025 at 3:00 PM
📢 We are hiring!
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
👩🏾⚕️Research technician/Lab manager
📍 @cabd-upo-csic.bsky.social , Sevilla, Spain
🧬 Gene regulation in animal development & evolution
Check the details 👇 & join us!
drive.google.com/file/d/1cZJi...
#ResearchTechnician #Zebrafish #GeneRegulation #DevelopmentalBiology
Reposted by Fany M. Real
Excited to post my first #JobOffer! I am looking for a research technician to help me build new projects from the grounds up at @cabd-upo-csic.bsky.social
We will use medaka to study how organs can be reprogrammed!
Details on how to apply below 👇
#JobOffer #ScienceJobs #EvoDevo #GeneRegulation
We will use medaka to study how organs can be reprogrammed!
Details on how to apply below 👇
#JobOffer #ScienceJobs #EvoDevo #GeneRegulation
September 19, 2025 at 8:53 AM
Excited to post my first #JobOffer! I am looking for a research technician to help me build new projects from the grounds up at @cabd-upo-csic.bsky.social
We will use medaka to study how organs can be reprogrammed!
Details on how to apply below 👇
#JobOffer #ScienceJobs #EvoDevo #GeneRegulation
We will use medaka to study how organs can be reprogrammed!
Details on how to apply below 👇
#JobOffer #ScienceJobs #EvoDevo #GeneRegulation
Reposted by Fany M. Real
Exciting talk today at #CABDseminars by Fernando García-Moreno from @achucarro.bsky.social ! Fernando explained the latest discoveries understanding brain evolution. Fernando was hosted by @fany-real.bsky.social
Thanks for coming @phylobrain.bsky.social!
Thanks for coming @phylobrain.bsky.social!
September 12, 2025 at 3:10 PM
Exciting talk today at #CABDseminars by Fernando García-Moreno from @achucarro.bsky.social ! Fernando explained the latest discoveries understanding brain evolution. Fernando was hosted by @fany-real.bsky.social
Thanks for coming @phylobrain.bsky.social!
Thanks for coming @phylobrain.bsky.social!
Reposted by Fany M. Real
We’re offering a fully funded 4 yr PhD position to work on Sexual selection in complex environments at the @uv.es. Co-supervised by @dbergerbiol.bsky.social. Find details below 👇
September 1, 2025 at 1:25 PM
We’re offering a fully funded 4 yr PhD position to work on Sexual selection in complex environments at the @uv.es. Co-supervised by @dbergerbiol.bsky.social. Find details below 👇
Reposted by Fany M. Real
#CABDseminars
"Neurogenesis and transcriptocs provide a new understanding of brain evolution" by Fernando García-Moreno, @achucarro.bsky.social
🗓️ September 12 th
⏰ 12 pm
📍Rosalind Franklin Auditorium at the CABD
Hosted by @fany-real.bsky.social
"Neurogenesis and transcriptocs provide a new understanding of brain evolution" by Fernando García-Moreno, @achucarro.bsky.social
🗓️ September 12 th
⏰ 12 pm
📍Rosalind Franklin Auditorium at the CABD
Hosted by @fany-real.bsky.social
September 8, 2025 at 10:32 AM
#CABDseminars
"Neurogenesis and transcriptocs provide a new understanding of brain evolution" by Fernando García-Moreno, @achucarro.bsky.social
🗓️ September 12 th
⏰ 12 pm
📍Rosalind Franklin Auditorium at the CABD
Hosted by @fany-real.bsky.social
"Neurogenesis and transcriptocs provide a new understanding of brain evolution" by Fernando García-Moreno, @achucarro.bsky.social
🗓️ September 12 th
⏰ 12 pm
📍Rosalind Franklin Auditorium at the CABD
Hosted by @fany-real.bsky.social
Reposted by Fany M. Real
#Preprint alert! 📣
We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements
www.biorxiv.org/cgi/content/...
We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements
www.biorxiv.org/cgi/content/...
MLL2 facilitates long-range gene regulation through LINE1 elements
Transcriptional regulation is tightly linked to chromatin organization, with H3K4me3 commonly marking both active and bivalent promoters. In embryonic stem cells (ESC), MLL2 is essential for H3K4me3 d...
www.biorxiv.org
August 13, 2025 at 5:54 AM
#Preprint alert! 📣
We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements
www.biorxiv.org/cgi/content/...
We are thrilled to share the work led by Lara Zorro-Shahidian and Lucio di Filippo, in which we show that #MLL2 controls gene expression in both #ESC and upon #differentiation by facilitating the #enhancer like activity of #LINE1 elements
www.biorxiv.org/cgi/content/...
Reposted by Fany M. Real
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Reposted by Fany M. Real
📢New paper in @natecoevo.nature.com!
🦇Research reveals that bat wings form by reusing existing genetic programs
By @molgen.mpg.de, @mdc-berlin.bsky.social,
@cabd-upo-csic.bsky.social (@dariloops.bsky.social, @fany-real.bsky.social) & CNAG (@mamartirenom.bsky.social)
www.cnag.eu/news/flying-...
🦇Research reveals that bat wings form by reusing existing genetic programs
By @molgen.mpg.de, @mdc-berlin.bsky.social,
@cabd-upo-csic.bsky.social (@dariloops.bsky.social, @fany-real.bsky.social) & CNAG (@mamartirenom.bsky.social)
www.cnag.eu/news/flying-...
July 30, 2025 at 9:02 AM
📢New paper in @natecoevo.nature.com!
🦇Research reveals that bat wings form by reusing existing genetic programs
By @molgen.mpg.de, @mdc-berlin.bsky.social,
@cabd-upo-csic.bsky.social (@dariloops.bsky.social, @fany-real.bsky.social) & CNAG (@mamartirenom.bsky.social)
www.cnag.eu/news/flying-...
🦇Research reveals that bat wings form by reusing existing genetic programs
By @molgen.mpg.de, @mdc-berlin.bsky.social,
@cabd-upo-csic.bsky.social (@dariloops.bsky.social, @fany-real.bsky.social) & CNAG (@mamartirenom.bsky.social)
www.cnag.eu/news/flying-...
Reposted by Fany M. Real
Here you can find the Research Briefing that accompanies our recent article — a quick, accessible overview of the key findings, future directions, and a bit of the story behind the work. 😉 rdcu.be/exPz7
Evolving a bat wing by reusing an existing gene program
Nature Ecology & Evolution - Interspecies comparative analyses of single-cell transcriptomic data reveal that a proximal limb gene program is reactivated during bat wing formation. Our results...
rdcu.be
July 28, 2025 at 10:22 AM
Here you can find the Research Briefing that accompanies our recent article — a quick, accessible overview of the key findings, future directions, and a bit of the story behind the work. 😉 rdcu.be/exPz7
Reposted by Fany M. Real
The official website is now open. I’m looking forward to meeting lots of limb researchers in Tokyo 🌸🐓🐀🐟🦎
cscenter.co.jp/limbdev26/
cscenter.co.jp/limbdev26/
Limb Development and Regeneration
cscenter.co.jp
July 24, 2025 at 9:09 AM
The official website is now open. I’m looking forward to meeting lots of limb researchers in Tokyo 🌸🐓🐀🐟🦎
cscenter.co.jp/limbdev26/
cscenter.co.jp/limbdev26/
Reposted by Fany M. Real
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
www.upf.edu
July 23, 2025 at 2:28 PM
🚨🚨🚨
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Please RT!
We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.
Deadline: 30/09/25👇
Reposted by Fany M. Real
How to represent genomes in 3D?
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
June 27, 2025 at 8:13 AM
How to represent genomes in 3D?
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
In this paper (and video), we propose Geometric Diagrams of Genomes (GDG)—a visual grammar that aims at emulating the effect ribbon diagrams (Richardson et al 1981) had in protein structural biology. Time will tell.😅
👉🏼 genomebiology.biomedcentral.com/articles/10....
Reposted by Fany M. Real
Un estudio revela que las alas de los murciélagos se forman reutilizando programas genéticos ya existentes
La investigación en la que ha participado el @cabd-upo-csic.bsky.social obtuvo datos sobre los programas genéticos que subyacen a cambios morfológicos durante la evolución
t.ly/rMKZt
La investigación en la que ha participado el @cabd-upo-csic.bsky.social obtuvo datos sobre los programas genéticos que subyacen a cambios morfológicos durante la evolución
t.ly/rMKZt
July 16, 2025 at 11:04 AM
Un estudio revela que las alas de los murciélagos se forman reutilizando programas genéticos ya existentes
La investigación en la que ha participado el @cabd-upo-csic.bsky.social obtuvo datos sobre los programas genéticos que subyacen a cambios morfológicos durante la evolución
t.ly/rMKZt
La investigación en la que ha participado el @cabd-upo-csic.bsky.social obtuvo datos sobre los programas genéticos que subyacen a cambios morfológicos durante la evolución
t.ly/rMKZt
Reposted by Fany M. Real
How did the bat get its wings? New research from a collaboration between the labs of Stefan Mundlos (MPIMG), Dario G. Lupiáñez, and Francisca M. Real (@cabd-upo-csic.bsky.social) show how genetic programs were reused during the evolution of mammalian flight. --> www.molgen.mpg.de/news-2025-fl...
Flying with hands – The evolution of bat wings
www.molgen.mpg.de
July 16, 2025 at 12:46 PM
How did the bat get its wings? New research from a collaboration between the labs of Stefan Mundlos (MPIMG), Dario G. Lupiáñez, and Francisca M. Real (@cabd-upo-csic.bsky.social) show how genetic programs were reused during the evolution of mammalian flight. --> www.molgen.mpg.de/news-2025-fl...
Thrilled to see our revised preprint now published in Nature Ecology & Evolution!
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!
www.nature.com/articles/s41...
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!
www.nature.com/articles/s41...
July 17, 2025 at 7:35 AM
Thrilled to see our revised preprint now published in Nature Ecology & Evolution!
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!
www.nature.com/articles/s41...
If you’re curious about how to build a bat wing by re-using existing gene programs, check out the link or the tutorial below. Big congratulations to all co-authors!! Thanks to reviewers!
www.nature.com/articles/s41...
Reposted by Fany M. Real
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
July 9, 2025 at 10:05 AM
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Reposted by Fany M. Real
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
www.nature.com
July 2, 2025 at 4:17 PM
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/
Reposted by Fany M. Real
Textbooks: “Enhancers are just a bunch of TFBSs”
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 🧵 (1/n)
Free access link: rdcu.be/erD22
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 🧵 (1/n)
Free access link: rdcu.be/erD22
June 18, 2025 at 5:56 PM
Textbooks: “Enhancers are just a bunch of TFBSs”
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 🧵 (1/n)
Free access link: rdcu.be/erD22
But how do they REALLY work?
New paper with many contributors here @berkeleylab.lbl.gov, @anshulkundaje.bsky.social, @anusri.bsky.social
A 🧵 (1/n)
Free access link: rdcu.be/erD22
Reposted by Fany M. Real
We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...
June 20, 2025 at 8:13 AM
We are delighted to share our new preprint “The evolution of gene regulatory programs controlling gonadal development in primates” www.biorxiv.org/content/10.1...
Happy to share our latest paper, where we “dive” into the evolutionary history of whale genomes. Check it out for more details!! 🐳🐋🧬
Genome-wide demographic analyses of balaenid whales revealed complex history of gene flow associated with past climate oscillation
Abstract. The balaenid whale, comprising three species of right whales and the bowhead whale, represents an ancient and highly endangered lineage of marine
academic.oup.com
May 7, 2025 at 10:56 AM
Happy to share our latest paper, where we “dive” into the evolutionary history of whale genomes. Check it out for more details!! 🐳🐋🧬
Reposted by Fany M. Real
We released our preprint on the CREsted package. CREsted allows for complete modeling of cell type-specific enhancer codes from scATAC-seq data. We demonstrate CREsted’s robust functionality in various species and tissues, and in vivo validate our findings: www.biorxiv.org/content/10.1...
April 3, 2025 at 2:30 PM
We released our preprint on the CREsted package. CREsted allows for complete modeling of cell type-specific enhancer codes from scATAC-seq data. We demonstrate CREsted’s robust functionality in various species and tissues, and in vivo validate our findings: www.biorxiv.org/content/10.1...
Reposted by Fany M. Real
🚨🚨#Hiring!
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
April 23, 2025 at 12:45 PM
🚨🚨#Hiring!
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG
📆 Apply by 23rd May 2023
🔗Details below
@sebioldev.bsky.social
Please RT!🙏
Reposted by Fany M. Real
Nature research paper: DNA-guided transcription factor interactions extend human gene regulatory code
https://go.nature.com/4j13XRc
https://go.nature.com/4j13XRc
DNA-guided transcription factor interactions extend human gene regulatory code - Nature
A large-scale analysis of DNA-bound transcription factors (TFs) shows how the presence of DNA markedly affects the landscape of TF interactions, and identifies composite motifs that are recognized by complexes of TFs rather than by individual ones.
go.nature.com
April 9, 2025 at 5:24 PM
Nature research paper: DNA-guided transcription factor interactions extend human gene regulatory code
https://go.nature.com/4j13XRc
https://go.nature.com/4j13XRc