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European Thyroid Journal
@eur-thyroid-j.bsky.social
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The international journal for basic, translational, and clinical #thyroidology. Fully #openaccess and the official journal of European Thyroid Association.
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New research by Jinyoung Kim et al. evaluates the clinical applicability of an AI model, AI‑Thyroid, for thyroid nodules with atypia of undetermined significance (AUS) cytology.

doi.org/10.1530/ETJ-25-0268
European Thyroid Journal logo. Artificial intelligence-assisted risk stratification of thyroid nodules with atypia of undetermined significance. By Jinyoung Kim et al. Figure 1. Study flow. This multicenter retrospective study enrolled patients from three data sources. Group 1 included patients identified from the Catholic Medical Center Clinical Data Warehouse, covering Seoul St. Mary’s Hospital, Yeouido St. Mary’s Hospital, and Eunpyeong St. Mary’s Hospital. Group 2 consisted of patients from Hanyang University Hospital. Group 3 comprised patients from Kangbuk Samsung Hospital. AUS, atypia of undetermined significance; FNA, fine-needle aspiration. European Thyroid Journal 15, 1; 10.1530/ETJ-25-0268
February 10, 2026 at 8:59 AM
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In a new multi‑institutional study, Sule Canberk et al. analyse 363 patients aged 0–25 years to assess the independent association between canonical somatic driver alterations and disease status at last clinical follow-up.

Read the full research #OpenAccess: doi.org/10.1530/ETJ-25-0310
European Thyroid Journal logo. The influence of age-independent somatic driver alterations on clinical outcomes in paediatric and young adult thyroid cancer. By Sule Canberk et al. Figure 1 Association between somatic mutation status and age group (n = 363). *Data are n (%). Cohort restricted to somatically tested patients with a known age group (n = 363). Percentages in positive/negative rows are row percentages; the total row shows column percentages (age distribution). Overall P-value: Pearson χ 2 (2 × 4); when expected counts were <5, the Fisher–Freeman–Halton exact test was used as a sensitivity check (results unchanged). NTRK1/3 = NTRK1 or NTRK3 fusion (union). RAS (N/H/K) = NRAS/KRAS/HRAS. Others = ALK, PAX8– PPARG, BRAF non-V600E, and other specified canonical alterations. Negative indicates the absence of the specified alteration and may include tumours with other driver mutations as well as wild type. Wild type denotes cases tested negative for all specified canonical drivers (Supplemental Table S1). European Thyroid Journal 15, 1; 10.1530/ETJ-25-0310
February 3, 2026 at 9:43 AM
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New research shows that EU‑TIRADS 4 nodules w back‑wall cystic figures (BWCF) have a lower malignancy risk than EU‑TIRADS 4 nodules w/out BWCF, reinforcing the importance of distinguishing BWCF from other hyperechoic foci to improve risk stratification.

Read the article: doi.org/10.1530/ETJ-25-0243
European Thyroid Journal logo. Can back-wall cystic figures of thyroid nodules predict benignity? By Jean-Guillaume Marchand et al. Table 2. Cytology results by EU-TIRADS category and BWCF presence, and statistical comparisons. European Thyroid Journal 15, 1; 10.1530/ETJ-25-0243.
January 27, 2026 at 5:18 PM
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How valuable is mir‑THYpe full in improving diagnosis & avoiding unnecessary thyroid surgeries?

Eduarda Gregorio Arnaut Lima et al. conducts the first external, independent, real‑world validation of this microRNA classifier.

Discover the results: doi.org/10.1530/ETJ-25-0105
European Thyroid Journal logo. External validation of a microRNA thyroid classifier: a real-world prospective study. By Eduarda Gregorio Arnaut Lima et al. Figure 1. Flowchart of the study evaluating thyroid nodules using the mir-THYpe full molecular test. Citation: European Thyroid Journal 14, 6; 10.1530/ETJ-25-0105
January 23, 2026 at 9:57 AM
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💫 Prof. van Santen, leading paediatric endocrinologist, specialises in endocrine effects of childhood cancer & paediatric thyroid cancer. We're delighted to have her as a Collection Editor on our latest collection.

⏰There's still time to contribute:
etj.bioscientifica.com/page/paediat...
Prof. Hanneke M van Santen. Current Approaches and Challenging Issues in Paediatric Thyroid Carcinoma Special Collection. Open for submissions. European Thyroid Journal logo. Collection Editors: Professor Marek Niedziela, Professor Hanneke M van Santen and Professor Andrew J Bauer.
January 16, 2026 at 11:05 AM
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How valuable is BRAF V600E as an independent prognostic marker?

A new review by Garcilaso Riesco‑Eizaguirre concludes that BRAF V600E remains a cornerstone, but its optimal clinical value will be realised within a precision‑oncology framework.

doi.org/10.1530/ETJ-25-0225
European Thyroid Journal logo. Novel Insights in Advanced Thyroid Carcinoma: From Mechanisms to Treatments Special Collection. New Review: BRAF V600E in thyroid cancer: navigating prognostic uncertainty and therapeutic opportunity. By Garcilaso Riesco-Eizaguirre Table 1 from: etj.bioscientifica.com/view/journals/etj/14/6/ETJ-25-0225.xml
January 13, 2026 at 1:41 PM
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A new systematic review by Natasha Dowell et al. evaluates the diagnostic test accuracy of the Afirma GSC & ThyroSeq v3 molecular tests in cytologically indeterminate thyroid nodules.

Read the article: doi.org/10.1530/ETJ-25-0296
European Thyroid Journal logo. Comparing the diagnostic accuracy of Afirma GSC to ThyroSeq V3 in cytologically indeterminate thyroid nodules. By Natasha Dowell et al. Figure 1. Preferred reporting items for systematic reviews and meta-analyses (PRISMA) flowchart. Citation: European Thyroid Journal 14, 6; 10.1530/ETJ-25-0296.
January 5, 2026 at 5:42 PM
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💙 Uniting for thyroid health in Africa

After the International Round Table - Global Challenges in Thyroid Health at the International Thyroid Congress, an editorial calls for collaboration among continental thyroid societies to strengthen clinical practice & advocacy.

doi.org/10.1530/ETJ-25-0374
European Thyroid Journal logo. New Editorial: Uniting continental thyroid societies to address challenges in thyroid health in Africa: a call to action. Read the editorial. European Thyroid Journal front cover.
December 16, 2025 at 11:35 AM
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A new review by Bernard Rees Smith, Ricardo Núñez Miguel & Jane Sanders explores the full-length human TSH receptor (TSHR) and how monoclonal autoantibodies activate or inhibit its function.

👉 Read the article: doi.org/10.1530/ETJ-25-0261
European Thyroid Journal logo. The thyrotropin receptor structure and interactions with autoantibodies. By Bernard Rees Smith, Ricardo Núñez Miguel, and Jane Sanders Figure 1 Cryo-EM structure of the full-length TSHR in two views rotated 180°. The structure is a monomer; all three domains are visible: leucine-rich repeat domain (LRD), hinge region (HR) and transmembrane domain (TMD). The structure is in cartoon representation, with the disulphide bonds and glycosylation sites in ball-and-stick representation, with oxygen in red, nitrogen in blue and sulphur in yellow. The glycans (shown in purple) are away from the concave surface of the TSHR-ECD, which interacts with TSHR autoantibodies. Cys301 forms a disulphide bond with Cys390, and the residues in between (amino acids 302–389) are missing from the structure. Reproduced with permission of the copyright holder, RSR Ltd. Citation: European Thyroid Journal 14, 6; 10.1530/ETJ-25-0261
December 8, 2025 at 3:32 PM
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Prof. Marek Niedziela, leading expert in paediatric thyroid diseases, is a Collection Editor for our latest Special Collection.

📢 Amplify your work - learn more: etj.bioscientifica.com/page/paediatric-thyroid-carcinoma/current-approaches-and-challenging-issues-in-paediatric-thyroid-carcinoma
Headshot of Marek Niedziela Professor Marek Niedziela, MD, PhD Head of the Department of Paediatric Endocrinology and Rheumatology Institute of Paediatrics Poznan University of Medical Sciences Poland Current Approaches and Challenging Issues in Paediatric Thyroid Carcinoma Special Collection. Open for Submissions. Collection Editors: Prof. Marek Niefziela, Prof. Hanneke M van Santen, Prof. Andrew J Bauer. European Thyroid Journal logo.
December 2, 2025 at 4:20 PM
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A new report by Ferdy S van Geest et al. describes a novel 8‑base‑pair duplication in THRB (c.1305_1312dup; (p.R438Lfs445X)) identified in a mosaic pattern in a patient with severe thyroid hormone β (RTHβ), resulting in a distinctive developmental & thyrotoxic phenotype.

doi.org/10.1530/ETJ-25-0092
European Thyroid Journal logo. Extreme resistance to thyroid hormone caused by a novel mosaic thyroid hormone receptor beta mutation. By Ferdy S van Geest et al. Figure 1 Clinical response to methimazole/Triac therapy. The light-blue bar indicates the age-specific reference interval for free T4; the light-red bar indicates the age-specific reference interval for TSH. The shaded bars indicate methimazole dose; the gray bars indicate Triac dose. Thyroid size is depicted as size of right lobe/size of isthmus/size of left lobe. Total thyroid volume was retrospectively assessed by an expert radiologist based on available ultrasound examinations, unless otherwise specified. *Thyroid volume was directly measured; the ultrasound technician deemed this an underestimation of actual thyroid volume. #A measurement of thyroid volume based on a CT scan is presented here;...Citation: European Thyroid Journal 14, 6; 10.1530/ETJ-25-0092.
November 25, 2025 at 9:17 AM
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🧬 Discover the emerging roles of DICER1 & DGCR8 in thyroid tumorigenesis and their impact on miRNA biogenesis and histopathologic diversity.

New open-access review by Lia Rodrigues et al. synthesises the latest evidence on miRNA biogenesis & histopathologic diversity: doi.org/10.1530/ETJ-25-0188
European Thyroid Journal logo. DICER1 and DGCR8 in thyroid tumorigenesis: miRNA biogenesis and histopathologic diversity. By Lia Rodrigues et al. Figure 1 miRNAs can be produced via the canonical pathway, involving the DROSHA–DGCR8 microprocessor complex, or through the non-canonical pathway from mirtrons in the nucleus. After exportation of the pre-miRNA by XPO5, cytoplasmic components such as DICER, TRBP, PACT, and AGO2 will process the pre-miRNA into the mature and active miRNA. Created with BioRender.com. European Thyroid Journal 14, 6; 10.1530/ETJ-25-0188
November 18, 2025 at 10:33 AM
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📢 Call for Papers: Paediatric Thyroid Carcinoma – Current Approaches & Challenges

Our latest special collection is led by international experts in the fields of paediatrics and endocrinology with a specialised interest in paediatric thyroid cancer.

Submit: [email protected]
🔗 bit.ly/4846F5v
European Thyroid Journal. Current Approaches and Challenging Issues in Paediatric Thyroid Carcinoma. Special Collection. Collection Editors: - Professor Marek Niedziela - Professor Hanneke M van Santen - Professor Andrew J Bauer
November 11, 2025 at 4:05 PM
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A new comprehensive review by Giulia Calafato et al. outlines the main somatic genetic and molecular alterations in thyroid tumors of follicular cells which drive tumour development and progression.

Read the review: doi.org/10.1530/ETJ-25-0104
Somatic genetic alterations in the development and progression in thyroid tumors of follicular cells in European Thyroid Journal. By Giulia Calafato et al.
November 5, 2025 at 9:29 AM
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🌐New research by Gloria Hoi-Yee Li introduces a novel algorithm & an electronic medical database from Hong Kong to establish the first large-scale registry of thyrotoxic periodic paralysis.

🔗Read the full study #OpenAccess: doi.org/10.1530/ETJ-25-0220
Twenty-year trend of thyrotoxicosis and thyrotoxic periodic paralysis: a population-based cohort study in European Thyroid Journal. By Gloria Hoi-Yee Li et al. Figure 1. Flowchart in identifying individuals with thyrotoxicosis and TPP in Hong Kong during 2002–2021. European Thyroid Journal 14, 5; 10.1530/ETJ-25-0220
October 28, 2025 at 8:55 AM
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🧬 Could a more systematic search for NUTM1 fusions improve the identification of poorly differentiated & anaplastic thyroid cancers?

Explore the article that supports the inclusion of NUTM1 fusions in RNA sequencing panels for advanced & refractory thyroid cancers.
doi.org/10.1530/ETJ-25-0100
European Thyroid Journal. NSD3::NUTM1 fusion evidenced on RNA sequencing in poorly differentiated thyroid cancer: a report of two cases in European Thyroid Journal. By Renaud Ciappuccini et al. Figure 1 Pathology features of patients 1 and 2. In patient 1, pathology revealed a 95 mm PDTC with a trabecular, insular solid component (70%) and a trabecular papillary component (30%). (A) Hematoxylin and eosin–stained sections (HES) from patient 1; magnification 20×). In patient 2, biopsy revealed a PDTC with an oncocytic component. (B) HES from patient 2; magnification 20×). Citation: European Thyroid Journal 14, 5; 10.1530/ETJ-25-0100
October 21, 2025 at 2:33 PM
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New research by Hiroshi Katoh et al. suggests lenvatinib may help rapidly relieve airway obstruction in thyroid cancer with tracheal invasion, and could serve as a bridging therapy during genetic testing in anaplastic thyroid cancer.

📖 Full research: doi.org/10.1530/ETJ-25-0212
Lenvatinib as an urgent initial therapy in thyroid cancer with remarkable laryngotracheal invasion in European Thyroid Journal. By Hiroshi Katoh et al. Figure 3. Waterfall plot of percentage change of the primary tumor diameters on the first CT scan after lenvatinib (LEN) initiation. European Thyroid Journal 14, 5; 10.1530/ETJ-25-0212
October 16, 2025 at 1:54 PM
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Latest research by Virginia Cappagli et al. assesses the prevalence of multifocality in MTC & aims to provide proof of concept that lobectomy can be safely performed.

Their findings support the more conservative surgical option for certain patients with sporadic MTC.

👉 doi.org/10.1530/ETJ-25-0074
Multifocality and bilaterality in medullary thyroid cancer: basis for a proof-of-concept safety of lobectomy in European Thyroid Journal. By Virginia Cappagli et al.
September 30, 2025 at 10:42 AM
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Hemithyroidectomy is chosen for low-risk DTC to preserve thyroid function, but the benefits in practice are lower than expected.

Tina Toft Kristensen et al. examine outcomes for patients managed under Danish guidelines, allowing TSH up to 4 mIU/L before LT4.

👉 doi.org/10.1530/ETJ-24-0282
Prevalence of endogenous normal thyroid function 3 years after hemithyroidectomy for differentiated thyroid cancer in European Thyroid Journal. By Tina Toft Kristensen et al. Figure 2. (A, B, C, D) Diagrams demonstrating the prevalence of levothyroxine treatment according to the postoperative TSH goal 1 and 3 years after hemithyroidectomy for DTC. TSH, thyroid stimulating hormone; ATA, American Thyroid Association. Citation: European Thyroid Journal 14, 5; 10.1530/ETJ-24-0282
September 24, 2025 at 8:39 AM
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Trailblazing research by Eline C Jager et al. has successfully cultured organoids from medullary thyroid carcinoma biopsies, offering a novel in vitro model for physiological studies, drug discovery, tracer testing and drug screening.

📖Read the full research #OpenAccess: doi.org/10.1530/ETJ-...
Patient-derived medullary thyroid cancer organoids: a potential model for mechanistic studies on diagnostics and therapy in European Thyroid Journal. By Eline C Jager et al. Figure 1 In vitro self-renewal of organoid-forming cells from human putative medullary thyroid cancer stem cells. (A) Schematic of medullary thyroid cancer tissue isolation, primary tissue culture, and the self-renewal assay. (B) Primary MTC-thyrospheres 7 days in culture (p0) and MTOs at the end of p1, p2, and p3. Scale bars, 100 μm. (C) Self-renewal potential of MTOs during passaging (n = 9 patients; error bars represent range). (D) In-medium secreted calcitonin and CEA levels from MTOs during passaging; calcitonin is plotted on the left y-axis, and CEA on the right y-axis (n = 3 patients; error bars represent SEM). European Thyroid Journal 14, 5; 10.1530/ETJ-24-0405
September 17, 2025 at 8:52 AM
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📈Paediatric thyroid cancer is rising, calling for advances in clinical practice.

This timely collection will explore the new WHO classification, Bethesda system alongside the challenges in evaluation & treatment.

Contribute today: [email protected]
🔗 bit.ly/4gjkdMQ
September 11, 2025 at 1:24 PM
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Therapeutics in Graves’ disease are rapidly evolving 🚀

Marius N. Stan @mayoclinic.org & Chrysoula Dosiou @stanford.edu explore how practices have shifted over time & the direction of future patient care.

👉 Read the full review: doi.org/10.1530/ETJ-25-0078

#GravesDisease #OpenAccess
European Thyroid Journal. The evolving therapeutic landscape of Graves' disease in adults: present and future. By Marius N Stan and Chrysoula Dosiou. Journal Cover.
September 10, 2025 at 9:34 AM
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Organoid technology at the forefront of thyroid cancer research.

New review by Eduardo Rios-Morris et al. @iribhm.bsky.social explores how patient- and stem-cell-derived models are transforming our understanding of complex molecular mechanisms & personalised medicine.

doi.org/10.1530/ETJ-24-0392
European Thyroid Journal. Novel Insights in Advanced Thyroid Carcinoma Special Collection. New Review: Development of 3D organoid models to study aggressive thyroid cancers. By Eduardo Rios-Morris et al.
September 10, 2025 at 9:16 AM
Reposted by European Thyroid Journal
inigolanda.bsky.social
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We've put together what I think is going to be a very good series of review articles on advanced thyroid cancer 📃

Mark this thread, I'll be posting articles as soon as they are released 📎

Published at the European Thyroid Journal 🦋 #OpenAccess

etj.bioscientifica.com/page/advance...
Novel Insights in Advanced Thyroid Carcinoma: From Mechanisms to Treatments
Advanced thyroid carcinoma
etj.bioscientifica.com
January 29, 2025 at 12:55 PM
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🆕Research by Lydia B Zablotska et al. defines thyroid ultrasound volume norms for an iodine-deficient population exposed to environmental radiation.

The studied Chernobyl cohort demonstrated substantial differences from MOH norms and WHO standards.

Open Access: doi.org/10.1530/ETJ-25-0085
Validation of established thyroid ultrasound volume norms in a Chernobyl cohort in European Thyroid Journal. By Lydia B Zablotska et al. Figure 2 Total thyroid volume reference curves with common percentiles (P) for thyroid volume (mL) according to age (years), separately for males and females. Citation: European Thyroid Journal 14, 4; 10.1530/ETJ-25-0085
September 9, 2025 at 2:30 PM