So excited about this new work from our CardioVar consortium out this week in Science led by the amazing Daniel Tabet and @fritzroth.bsky.social.

www.science.org/doi/10.1126/

Honored to join Benjamin Meder and treasured colleagues at the 10th anniversary celebration of the Institute for Cardiomyopathies in Heidelberg. Hot on the heels of our Leducq Network meeting on cardiac splicing! Thanks for wonderful hospitality and stimulating science.❤️

I had the honor of remembering and celebrating our friend Atul Butte today at a special symposium at the AGBT Precision Health meeting in San Diego. I shared the stage with superstars Chris Longhurst, Marina Sirota, Lucila Ohno-Machado, and Bimal Chaudhari.

In this new opinion piece, we explore our belief that AI can make a significant impact on health by helping humans increase their physical activity. A new version of the My Heart Counts app will soon help us test that idea.

www.ahajournals.org/doi/10.1161/...

Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.

Great to spend some time with the incomparable @mcuban.bsky.social talking origin stories, healthcare disruption, entrepreneurship, and the NBA draft.

We are recruiting a Division Chief for Infectious Diseases and Geographic Medicine.

If you have a vision for the future of infectious disease and are passionate about driving innovation in healthcare, we invite you to learn more and apply:

facultypositions.stanford.edu/en-us/job/49...

Stanford Department of Medicine is recruiting a Division Chief for Gastroenterology and Hepatology.

If you're passionate about advancing digestive health and leading a dynamic team, I invite you to apply.

facultypositions.stanford.edu/en-us/job/49...

A pleasure to chat with Patrick on my favorite topics…genomes, sequencing, AI, and curing genetic disease!

pod.fo/e/2cc43f

YouTube:
youtu.be/jm4C3SqvIAI?...

Paper: www.nature.com/articles/s41...
Data: motrpac-data.org

Thanks to Sports Illustrated for featuring our consortium's work building a molecular map of exercise.

Some more details on our recent work with the Google Health AI team.

research.google/blog/advanci...

Manuscript: arxiv.org/abs/2410.03741

Little known fact: Die Hard 2 — also a Christmas movie.

Fall colors at Stanford

Thoughts today are with those spending Thanksgiving away from their families in hospital. Special thanks to our extraordinary health care workers, nurses, and doctors here at Stanford and around the world who are there for them every day. But especially on this day, I am so grateful for you all.

No one chooses to be in hospital for Thanksgiving but, if you had to be, then maybe the winter double rainbows from the J7 wing of Stanford hospital could help the healing a little bit. ❤️

These are remarkable results and while it is early days, this represents new hope for millions of patients worldwide with severe inherited cardiovascular disease. Congrats to the entire team of investigators.

For more on these disorders, see med.stanford.edu/familyheart

7 boys received an AAV9 containing LAMP2B transgene.
Side effects were significant but transient and reversible. In 1 case, the disease continued to progress. In 6 cases, there was evidence of cardiac expression of the missing protein and stabilization or improvement of clinical features.

In today's NEJM and at the American Heart Association meeting, a notable report of cardiac directed gene therapy.

Danon disease is a severe progressive X-linked storage disorder causing cardiomyopathy and early death in males. It is caused by loss of function mutations in the LAMP2 gene.