Erin Doherty
@erinedoherty.bsky.social
Postdoc @ Doudna Lab, UC Berkeley 🧬 | Chemical & Structural Biology | Immunity Mechanisms | CRISPR | RNA-Editing |
F32 NRSA | Berkeley Chancellor's Fellow
UC Davis Beal Lab Alum | Former CIRM, NIH F31 & NIH T32
F32 NRSA | Berkeley Chancellor's Fellow
UC Davis Beal Lab Alum | Former CIRM, NIH F31 & NIH T32
Excited to share our new preprint co-led by @jnoms.bsky.social!
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Here we reveal an exceptional diversity of viral 2H phosphodiesterases (PDEs) that enable immune evasion by selectively degrading oligonucleotide-based messengers. This 2H PDE fold has evolved striking substrate breath & specificity.
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...
www.biorxiv.org
November 25, 2025 at 9:13 PM
So grateful for the collective action that reversed this decision - the PPFP will continue!
November 23, 2025 at 2:14 AM
So grateful for the collective action that reversed this decision - the PPFP will continue!
Thank you, Jason!!
October 17, 2025 at 10:42 PM
Thank you, Jason!!
The link is not broken despite what the preview says :)
October 17, 2025 at 9:17 PM
The link is not broken despite what the preview says :)
Thanks to this fantastic, interdisciplinary team for making it happen! @benadler.bsky.social, Peter Yoon, Kendall Hsieh, @kenjmloi.bsky.social , Emily Armbruster, @arushi-lahiri.bsky.social , Cydni Bolling, Xander Wilcox, Amogha Akkati, Tony Iavarone, Joe Pogliano, and Jennifer Doudna
October 2, 2025 at 3:21 AM
Thanks to this fantastic, interdisciplinary team for making it happen! @benadler.bsky.social, Peter Yoon, Kendall Hsieh, @kenjmloi.bsky.social , Emily Armbruster, @arushi-lahiri.bsky.social , Cydni Bolling, Xander Wilcox, Amogha Akkati, Tony Iavarone, Joe Pogliano, and Jennifer Doudna
And thanks to @mfwhite2.bsky.social for this great perspective on both works! www.nature.com/articles/d41...
Bacteria use a decoy defence molecule to set a trap for viruses
Some bacterial-infecting viruses use ‘sponges’ to mop up defence molecules, but bacteria can fight back by responding when a sponge captures decoy molecules.
www.nature.com
October 2, 2025 at 3:17 AM
And thanks to @mfwhite2.bsky.social for this great perspective on both works! www.nature.com/articles/d41...
Very excited to see our work appear alongside findings from @aaronwhiteley.bsky.social & @benmorehouse.bsky.social !
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The Panoptes system uses decoy cyclic nucleotides to defend against phage - Nature
The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.
www.nature.com
October 2, 2025 at 3:16 AM
Very excited to see our work appear alongside findings from @aaronwhiteley.bsky.social & @benmorehouse.bsky.social !
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This also leads to a major constraint for the evolution of viral proteins that inhibit immune signaling, which we explored in recent pre-print co-led with @jnoms.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to humans. In response, viruses use phosphodiesterase...
www.biorxiv.org
October 2, 2025 at 3:06 AM
This also leads to a major constraint for the evolution of viral proteins that inhibit immune signaling, which we explored in recent pre-print co-led with @jnoms.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Immune activation upon cyclic oligonucleotide depletion prevents the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides.
October 2, 2025 at 3:05 AM
Immune activation upon cyclic oligonucleotide depletion prevents the spread of viruses that attempt immune evasion by depleting host cyclic nucleotides.