epithelial mechanics fan club
@epimechfc.bsky.social
📚 We're your source for papers on various #EpithelialMechanics topics 🔍 & platform to share your research and passion 🧫🔬
Like to write a thread? Please DM us!
💬 @onenimesa.bsky.social & @juliaeckert.bsky.social
👉 https://epithelialmechanics.github.io
Like to write a thread? Please DM us!
💬 @onenimesa.bsky.social & @juliaeckert.bsky.social
👉 https://epithelialmechanics.github.io
Qu, L., Zhao, S., Huang, Y., Ye, X., Wang, K., Liu, Y., Liu, X., Mao, H., Hu, G., Chen, W., Guo, C., He, J., ...,Chen, L., & Zhao, W. (2024). Self-inspired learning for denoising live-cell super-resolution microscopy. Nature methods, 21(10), 1895–1908. #EpithelialMechanics
buff.ly/3CPtItA
buff.ly/3CPtItA
November 28, 2025 at 8:01 AM
Qu, L., Zhao, S., Huang, Y., Ye, X., Wang, K., Liu, Y., Liu, X., Mao, H., Hu, G., Chen, W., Guo, C., He, J., ...,Chen, L., & Zhao, W. (2024). Self-inspired learning for denoising live-cell super-resolution microscopy. Nature methods, 21(10), 1895–1908. #EpithelialMechanics
buff.ly/3CPtItA
buff.ly/3CPtItA
González-Martín, M., Martínez-Ara, G., Ngo, J. T., Trepat, X., & Roca-Cusachs, P. (2025). Synthetic mechanotransduction. Nature Reviews Bioengineering, 1-14. #EpithelialMechanicsReviews
buff.ly/nkVtz6I
buff.ly/nkVtz6I
November 27, 2025 at 8:01 AM
González-Martín, M., Martínez-Ara, G., Ngo, J. T., Trepat, X., & Roca-Cusachs, P. (2025). Synthetic mechanotransduction. Nature Reviews Bioengineering, 1-14. #EpithelialMechanicsReviews
buff.ly/nkVtz6I
buff.ly/nkVtz6I
Hill, K., Griffing, A. H., Palmer, M. A., Lemma, B., Lupo, A. S., Gamble, T., ... & Nelson, C. M. (2025). Biophysical processes of morphogenesis in lizard lungs. Developmental Dynamics. #EpithelialMechanics
buff.ly/5gevBeQ
buff.ly/5gevBeQ
November 26, 2025 at 8:01 AM
Hill, K., Griffing, A. H., Palmer, M. A., Lemma, B., Lupo, A. S., Gamble, T., ... & Nelson, C. M. (2025). Biophysical processes of morphogenesis in lizard lungs. Developmental Dynamics. #EpithelialMechanics
buff.ly/5gevBeQ
buff.ly/5gevBeQ
Zhang, Y., Kini, S. A., Mishkanian, S. A., Yarishkin, O., Luo, R., Seradj, S. H., ... & Patapoutian, A. (2025). PIEZO channels link mechanical forces to uterine contractions in parturition. Science, #EpithelialMechanics
buff.ly/7XSrbXX
buff.ly/7XSrbXX
November 25, 2025 at 8:00 AM
Zhang, Y., Kini, S. A., Mishkanian, S. A., Yarishkin, O., Luo, R., Seradj, S. H., ... & Patapoutian, A. (2025). PIEZO channels link mechanical forces to uterine contractions in parturition. Science, #EpithelialMechanics
buff.ly/7XSrbXX
buff.ly/7XSrbXX
More generally, we reviewed how epithelial mechanics drive tissue architecture in
physiology, and how this mechanical cues go awry in cancer here: buff.ly/Z3q2wy6
physiology, and how this mechanical cues go awry in cancer here: buff.ly/Z3q2wy6
November 23, 2025 at 8:01 AM
More generally, we reviewed how epithelial mechanics drive tissue architecture in
physiology, and how this mechanical cues go awry in cancer here: buff.ly/Z3q2wy6
physiology, and how this mechanical cues go awry in cancer here: buff.ly/Z3q2wy6
For those interested in how epithelial geometry/architecture affects cancers, from
tumorigenesis to metastatic spread, we reviewed this nascent field here: buff.ly/tCCChoJ
tumorigenesis to metastatic spread, we reviewed this nascent field here: buff.ly/tCCChoJ
November 23, 2025 at 8:01 AM
For those interested in how epithelial geometry/architecture affects cancers, from
tumorigenesis to metastatic spread, we reviewed this nascent field here: buff.ly/tCCChoJ
tumorigenesis to metastatic spread, we reviewed this nascent field here: buff.ly/tCCChoJ
These mechanical consequences of tumour architecture may further impact cancer
cell biology, even at the DNA level. Dysregulated tensions can cause errors in
chromosome segregation, and contribute to genomic instability in an incipient lesion.
buff.ly/pSVSOly
cell biology, even at the DNA level. Dysregulated tensions can cause errors in
chromosome segregation, and contribute to genomic instability in an incipient lesion.
buff.ly/pSVSOly
November 23, 2025 at 8:01 AM
These mechanical consequences of tumour architecture may further impact cancer
cell biology, even at the DNA level. Dysregulated tensions can cause errors in
chromosome segregation, and contribute to genomic instability in an incipient lesion.
buff.ly/pSVSOly
cell biology, even at the DNA level. Dysregulated tensions can cause errors in
chromosome segregation, and contribute to genomic instability in an incipient lesion.
buff.ly/pSVSOly
The interfacial geometry of the epithelium has direct mechanical effects on cancer
cells. In regions of higher tension, cancer cells acquire stem cell properties. This was
demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social
buff.ly/GYlyEBH
cells. In regions of higher tension, cancer cells acquire stem cell properties. This was
demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social
buff.ly/GYlyEBH
November 23, 2025 at 8:01 AM
The interfacial geometry of the epithelium has direct mechanical effects on cancer
cells. In regions of higher tension, cancer cells acquire stem cell properties. This was
demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social
buff.ly/GYlyEBH
cells. In regions of higher tension, cancer cells acquire stem cell properties. This was
demonstrated in 3D cultures of multiples shapes using melanoma cells. @kriskilian.bsky.social
buff.ly/GYlyEBH
From early stages of skin carcinogenesis, benign basal carcinomas secrete de novo
basement membrane (BM) components and acquire bud shapes. Malignant
squamous carcinomas don’t secrete BM proteins and acquire fold shapes.
@ElaineFuchsLab
basement membrane (BM) components and acquire bud shapes. Malignant
squamous carcinomas don’t secrete BM proteins and acquire fold shapes.
@ElaineFuchsLab
November 23, 2025 at 8:01 AM
From early stages of skin carcinogenesis, benign basal carcinomas secrete de novo
basement membrane (BM) components and acquire bud shapes. Malignant
squamous carcinomas don’t secrete BM proteins and acquire fold shapes.
@ElaineFuchsLab
basement membrane (BM) components and acquire bud shapes. Malignant
squamous carcinomas don’t secrete BM proteins and acquire fold shapes.
@ElaineFuchsLab
Malignant transformation triggers hyperproliferation within a confined space. The geometric characteristics of ductal epithelia such as pancreatic ducts will determine whether a tumor can grow into the lumen or outwards. @behrens_lab buff.ly/5g6oyOV
November 23, 2025 at 8:01 AM
Malignant transformation triggers hyperproliferation within a confined space. The geometric characteristics of ductal epithelia such as pancreatic ducts will determine whether a tumor can grow into the lumen or outwards. @behrens_lab buff.ly/5g6oyOV
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
November 23, 2025 at 8:01 AM
It’s time to talk about epithelial geometry and cancer. How can the architecture of an epithelium affect how tumors will grow and spread? In this thread, @jorgealmagro.bsky.social
Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M., & Kilian, K. A. (2016). Interfacial geometry dictates cancer cell tumorigenicity. Nature materials, doi.org/10.1038/nmat... #EpithelialMechanics
November 21, 2025 at 8:01 AM
Lee, J., Abdeen, A. A., Wycislo, K. L., Fan, T. M., & Kilian, K. A. (2016). Interfacial geometry dictates cancer cell tumorigenicity. Nature materials, doi.org/10.1038/nmat... #EpithelialMechanics
Fiore, V. F., Almagro, J., & Fuchs, E. (2025). Shaping epithelial tissues by stem cell mechanics in development and cancer. Nature Reviews Molecular Cell Biology, doi.org/10.1038/s415... #EpithelialMechanicsReviews
November 20, 2025 at 8:01 AM
Fiore, V. F., Almagro, J., & Fuchs, E. (2025). Shaping epithelial tissues by stem cell mechanics in development and cancer. Nature Reviews Molecular Cell Biology, doi.org/10.1038/s415... #EpithelialMechanicsReviews
Almagro, J., Messal, H. A., Elosegui-Artola, A., van Rheenen, J., & Behrens, A. (2022). Tissue architecture in tumor initiation and progression. Trends in cancer, doi.org/10.1016/j.tr... #EpithelialMechanicsReviews
November 19, 2025 at 8:00 AM
Almagro, J., Messal, H. A., Elosegui-Artola, A., van Rheenen, J., & Behrens, A. (2022). Tissue architecture in tumor initiation and progression. Trends in cancer, doi.org/10.1016/j.tr... #EpithelialMechanicsReviews
Knouse, K. A., Lopez, K. E., Bachofner, M., & Amon, A. (2018). Chromosome segregation fidelity in epithelia requires tissue architecture. Cell, doi.org/10.1016/j.ce... #EpithelialMechanics
November 18, 2025 at 8:01 AM
Knouse, K. A., Lopez, K. E., Bachofner, M., & Amon, A. (2018). Chromosome segregation fidelity in epithelia requires tissue architecture. Cell, doi.org/10.1016/j.ce... #EpithelialMechanics
Messal, H. A., Alt, S., Ferreira, R. M., Gribben, C., Wang, V. M. Y., Cotoi, C. G., ... & Behrens, A. (2019). Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature, doi.org/10.1038/s415... #EpithelialMechanics
November 17, 2025 at 8:00 AM
Messal, H. A., Alt, S., Ferreira, R. M., Gribben, C., Wang, V. M. Y., Cotoi, C. G., ... & Behrens, A. (2019). Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis. Nature, doi.org/10.1038/s415... #EpithelialMechanics
In many developmental systems, cells don’t read out pre-established gradients, but interact to self-organize shapes. How can we quantify the information in self-organized patterns? We recently proposed how to measure the total information in a pattern.
buff.ly/4AWd5Hk
buff.ly/4AWd5Hk
November 15, 2025 at 8:00 AM
In many developmental systems, cells don’t read out pre-established gradients, but interact to self-organize shapes. How can we quantify the information in self-organized patterns? We recently proposed how to measure the total information in a pattern.
buff.ly/4AWd5Hk
buff.ly/4AWd5Hk
Beyond the fly, many other systems are controlled by morphogens. The patterning of the vertebrate neural tube is controlled by two opposing gradients, which together provide high spatial precision for cell decisions.
buff.ly/oGeaTex
buff.ly/oGeaTex
November 15, 2025 at 8:00 AM
Beyond the fly, many other systems are controlled by morphogens. The patterning of the vertebrate neural tube is controlled by two opposing gradients, which together provide high spatial precision for cell decisions.
buff.ly/oGeaTex
buff.ly/oGeaTex
For a comprehensive review on the history, concept, and mathematics of PI, check out “The many bits of positional information” by Gasper Tkacik and @thomasgregor.bsky.social.
buff.ly/61xmO7O
buff.ly/61xmO7O
November 15, 2025 at 8:00 AM
For a comprehensive review on the history, concept, and mathematics of PI, check out “The many bits of positional information” by Gasper Tkacik and @thomasgregor.bsky.social.
buff.ly/61xmO7O
buff.ly/61xmO7O
Could one measure the information in such gradients? Combining imaging and information theory, @thomasgregor.bsky.social, William Bialek & Co. measured 4.2 bits of PI in the early fly gap genes (downstream of Bicoid) – enough for each cell to infer its position.
buff.ly/61xmO7O
buff.ly/61xmO7O
November 15, 2025 at 8:00 AM
Could one measure the information in such gradients? Combining imaging and information theory, @thomasgregor.bsky.social, William Bialek & Co. measured 4.2 bits of PI in the early fly gap genes (downstream of Bicoid) – enough for each cell to infer its position.
buff.ly/61xmO7O
buff.ly/61xmO7O
20 years later, the first morphogen molecule was discovered: Driever & Nüsslein-Volhard discovered that Bicoid mRNA placed by the mother fly at the anterior of the embryo establishes a gradient and controls cell fate.
buff.ly/a2lGTYz
buff.ly/a2lGTYz
November 15, 2025 at 8:00 AM
20 years later, the first morphogen molecule was discovered: Driever & Nüsslein-Volhard discovered that Bicoid mRNA placed by the mother fly at the anterior of the embryo establishes a gradient and controls cell fate.
buff.ly/a2lGTYz
buff.ly/a2lGTYz
During development, stem cells decide their fate based on input chemicals, called morphogens. In 1967, Lewis Wolpert proposed that gradients of such chemicals could tell cells where they are in the tissue, and thus carry positional information (PI).
buff.ly/p7NvbM3
buff.ly/p7NvbM3
November 15, 2025 at 8:00 AM
During development, stem cells decide their fate based on input chemicals, called morphogens. In 1967, Lewis Wolpert proposed that gradients of such chemicals could tell cells where they are in the tissue, and thus carry positional information (PI).
buff.ly/p7NvbM3
buff.ly/p7NvbM3
Hi, I’m David Brückner @davidbrueckner.bsky.social.
I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.
buff.ly/RFxVeHh
I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.
buff.ly/RFxVeHh
November 15, 2025 at 8:00 AM
Hi, I’m David Brückner @davidbrueckner.bsky.social.
I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.
buff.ly/RFxVeHh
I’ll take you through how cells in a tissue can use information distributed by biochemical gradients to make decisions, and how we can measure such positional information.
buff.ly/RFxVeHh
Dubuis, J. O., Tkačik, G., Wieschaus, E. F., Gregor, T., & Bialek, W. (2013). Positional information, in bits. Proceedings of the National Academy of Sciences, doi.org/10.1073/pnas... #EpithelialMechanics
November 14, 2025 at 8:01 AM
Dubuis, J. O., Tkačik, G., Wieschaus, E. F., Gregor, T., & Bialek, W. (2013). Positional information, in bits. Proceedings of the National Academy of Sciences, doi.org/10.1073/pnas... #EpithelialMechanics
Petkova, M. D., Tkačik, G., Bialek, W., Wieschaus, E. F., & Gregor, T. (2019). Optimal decoding of cellular identities in a genetic network. Cell, #EpithelialMechanics doi.org/10.1016/j.ce...
November 13, 2025 at 11:00 AM
Petkova, M. D., Tkačik, G., Bialek, W., Wieschaus, E. F., & Gregor, T. (2019). Optimal decoding of cellular identities in a genetic network. Cell, #EpithelialMechanics doi.org/10.1016/j.ce...