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epilepsia-open.bsky.social
Epilepsia Open
@epilepsia-open.bsky.social
43 followers 5 following 180 posts
The open access journal of the International League against Epilepsy
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epilepsia-open.bsky.social
We performed epilepsy surgery in experimental models of focal onset seizures to investigate the effectiveness of surgeries using neurophysiological and metabolic changes before and after the surgery.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #DBS #kainicacid #kindling
November 21, 2025 at 6:37 PM
epilepsia-open.bsky.social
RNS with neocortical depth leads achieved 66.7% seizure reduction at 1 year and 77.5% at long term follow up.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #depthelectrode #neocortex #networkremodeling #responsiveneurostimulation #RNS #seizure #sEEG
November 21, 2025 at 6:36 PM
epilepsia-open.bsky.social
This post hoc analysis evaluates perampanel as first adjunctive therapy for epilepsy across different clinical and regional settings.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #firstaddontherapy #focalepilepsy #focalonsetseizures #tonicclonicseizures #perampanel
November 20, 2025 at 5:18 PM
epilepsia-open.bsky.social
Epilepsy is associated with significantly increased long-term risk of cardiovascular disease.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #cardiovasculardiseases #riskfactors #SouthKorea
November 19, 2025 at 7:04 PM
epilepsia-open.bsky.social
This is a pediatric case series of patients suffering from multifocal or generalized drug-resistant epilepsy treated with centromedian RNS.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #centromediannucleus #thalamus #drugresistantepilepsy #pediatric #responsiveneurostimulation
November 17, 2025 at 4:27 PM
epilepsia-open.bsky.social
We compared the early adjuvant treatment outcomes of IV lacosamide and levetiracetam for status epilepticus after benzodiazepine use.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antiseizuremedication #diagnosisprocedurecombination #overlapweighting #propensityscore #seizure
November 17, 2025 at 4:26 PM
epilepsia-open.bsky.social
Combined multimodal imaging (82–100% sensitivity) outperforms single modalities for localizing epileptogenic foci in surgical candidates.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #multimodalimaging #neuroimaging #radiosurgery #stereotactic
November 13, 2025 at 6:51 PM
epilepsia-open.bsky.social
The study compared the effectiveness of 5 mg melatonin versus partial sleep deprivation in inducing sleep during nap-time EEG in children with epilepsy.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #melatonin #napEEG #sleepinduction #sleeplatency
November 12, 2025 at 4:08 PM
epilepsia-open.bsky.social
This review provides a practical approach to assessing and selecting PROMs, and discusses how they may be incorporated into clinic workflows.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #mooddisorders #patientreportedoutcome #qualityoflife #seizure
November 11, 2025 at 3:46 PM
epilepsia-open.bsky.social
New in Epilepsia Open – November 9, 2025
mailchi.mp/ilae/epileps...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
November 10, 2025 at 3:51 PM
epilepsia-open.bsky.social
Global adolescent epilepsy burden increased 1990–2021, with marked regional and SDI disparities.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #adolescenthealth #globalburdenofdisease #healthpolicy #publichealth
November 7, 2025 at 3:33 PM
epilepsia-open.bsky.social
Approximately, 26% patients with unexplained seizures or epilepsy deterioration tested positive for autoimmune or paraneoplastic antibodies.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #antibodytesting #APEscore #autoimmuneencephalitis #EEG #paraneoplasticencephalitis
November 7, 2025 at 3:32 PM
epilepsia-open.bsky.social
After a median follow-up of 20 months, CBD was globally effective and safe in 107 patients with LGS, DS, TSC, and other DEEs.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #CBD #DEE #Dravetsyndrome #LennoxGastautsyndrome #realworld #cannabidiol
November 6, 2025 at 5:05 PM
epilepsia-open.bsky.social
This MR study assessed causal links between thousands of plasma proteins and epilepsy risk.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #causalinference #GWAS #MR #plasmaproteins
November 5, 2025 at 2:56 PM
epilepsia-open.bsky.social
The preponderance of evidence indicates that the KD is effective in targeting IESS.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #acidosis #infantileepilepticspasms #ketogenicdiet #microbiome #tryptophan
November 4, 2025 at 5:50 PM
epilepsia-open.bsky.social
Serum phosphate measurements are rarely included in the acute evaluation of Transient Loss of Consciousness (TLoC).
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #biomarker #electrolyte #hypophosphatemia #seizure #telemedicine
November 3, 2025 at 7:32 PM
epilepsia-open.bsky.social
Letter and Response - Addressing "SCN1A gain of function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications"

Letter: doi.org/10.1002/epi4...
Authors’ Response: doi.org/10.1002/epi4...
Original Article: doi.org/10.1002/epi4...

#Epilepsiaopen #Epilepsy #ILAE
To the editors: SCN1A gain‐of‐function effects in Dravet syndrome: Insights into clinical phenotypes and therapeutic implications
Click on the article title to read more.
doi.org
October 28, 2025 at 5:45 PM
epilepsia-open.bsky.social
New in Epilepsia Open – October 26, 2025
mailchi.mp/ilae/epileps...

Subscribe - eepurl.com/iLSrNc

#epilepsy #epilepsiaopen #ILAE #EpilepsyResearch #NewInEpilepsy #JustPublished #LatestResearch
October 27, 2025 at 7:37 PM
epilepsia-open.bsky.social
The degree and frequency of language decline reported in research literature are influenced by the protocols used to assess language functions.
doi.org/10.1002/epi4...

#epilepsy #ILAE #epilepsiaopen #confrontationnaming #languageoutcomes #reliablechange #temporallobeepilepsy #verbalfluency
October 27, 2025 at 7:36 PM
epilepsia-open.bsky.social
69.8% of epilepsy patients preferred in-person care despite high digital literacy and environmental concern.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #climatechange #telemedicine #digitalliteracy #enviromentalawareness
October 23, 2025 at 2:28 PM
epilepsia-open.bsky.social
Progressive clonic slowing is associated with marked oxygen desaturation during bilateral tonic–clonic seizures.
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #SUDEP #Progressiveclonicslowing #PostictalImmobility #Tonicclonicseizure #Respiratorydysfunction
October 22, 2025 at 7:22 PM
epilepsia-open.bsky.social
The multiple-hit rat model is a model of structural etiology drug-resistant infantile epileptic spasms syndrome (IESS).
doi.org/10.1002/epi4...

#epilepsy #ilae #epilepsiaopen #Sivelestat #fingolimod #methylprednisolone #topiramate #insulingrowthfactor
October 21, 2025 at 4:32 PM
epilepsia-open.bsky.social
To target seizure freedom, physicians should aim to optimize treatment, minimize delays, and improve medication adherence.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #antiseizuremedications #inflammation #qualityoflife #seizure
October 20, 2025 at 6:20 PM
epilepsia-open.bsky.social
Although most became eligible to drive after VNS implantation without significant medication changes, some required additional medication changes to achieve seizure control.
doi.org/10.1002/epi4...

#epilepsy #epilepsiaopen #ILAE #driving #drugresistantepilepsy #vagusnervestimulation #VNS
October 17, 2025 at 4:53 PM
epilepsia-open.bsky.social
We present the largest series reporting on the off-label use of Cenobamate (CNB) in 16 adults with drug-resistant idiopathic generalized epilepsy, including 12 with JME.
onlinelibrary.wiley.com/doi/10.1002/...

#epilepsy #ilae #epilepsiaopen #antiseizuremedication #Cenobamate #healthcareutilization
October 17, 2025 at 4:52 PM