Ellen Leffler
@ellenleffler.bsky.social
Assistant prof of human genetics @ UUtah. Language and food enthusiast, mom.
Thanks to a constructive peer review, the published paper in PLoS Pathogens is stronger than the preprint, so thanks to the editor and reviewers!
June 18, 2025 at 9:56 PM
Thanks to a constructive peer review, the published paper in PLoS Pathogens is stronger than the preprint, so thanks to the editor and reviewers!
We also identify genes with high SNP density, including genes in the Hep1 and Hep2 gene families, which are unique to Hepatocystis. This might suggest they are under selection for immune evasion, despite Hepatocystis lacking blood stage replication.
June 18, 2025 at 9:56 PM
We also identify genes with high SNP density, including genes in the Hep1 and Hep2 gene families, which are unique to Hepatocystis. This might suggest they are under selection for immune evasion, despite Hepatocystis lacking blood stage replication.
This gave us low-coverage whole-genome sequencing data for Hepatocystis from baboons and five species of Chlorocebus monkeys-- and so a first look at genetic variation and population structure genome-wide. There is support for substructure by host species, which was not as clear from mtDNA only.
June 18, 2025 at 9:56 PM
This gave us low-coverage whole-genome sequencing data for Hepatocystis from baboons and five species of Chlorocebus monkeys-- and so a first look at genetic variation and population structure genome-wide. There is support for substructure by host species, which was not as clear from mtDNA only.
Thanks to a constructive peer review, the published paper in PLoS Pathogens is stronger than the preprint, so thanks to the editor and reviewers!
June 18, 2025 at 9:52 PM
Thanks to a constructive peer review, the published paper in PLoS Pathogens is stronger than the preprint, so thanks to the editor and reviewers!
We also identify genes with high SNP density, including genes in the Hep1 and Hep2 gene familiels, which are unique to Hepatocystis. This might suggest they are under selection for immune evasion, despite Hepatocystis lacking blood stage replication
June 18, 2025 at 9:49 PM
We also identify genes with high SNP density, including genes in the Hep1 and Hep2 gene familiels, which are unique to Hepatocystis. This might suggest they are under selection for immune evasion, despite Hepatocystis lacking blood stage replication
This gave us low-coverage whole-genome sequencing data for Hepatocystis from baboons and five species of Chlorocebus monkeys-- and so a first look at genetic variation and population structure genome-wide. There is support for substructure by host species, which was not as clear from mtDNA only.
June 18, 2025 at 9:47 PM
This gave us low-coverage whole-genome sequencing data for Hepatocystis from baboons and five species of Chlorocebus monkeys-- and so a first look at genetic variation and population structure genome-wide. There is support for substructure by host species, which was not as clear from mtDNA only.