Finally, using SLDSC and a TWAS-like approach, we highlight stability-regulated events that may explain risk for multiple autoimmune diseases. (6/n)

Stability-regulating variants were enriched among the target sites of known RNA stability-regulators, such as microRNAs and decay-related proteins such as UPF1. We validated these variants using massively parallel assays and CRISPR prime editing experiments. (5/n)

Among GTEx eQTLs, stability-regulated genes had similar enrichment to that of transcriptionally-regulated genes, underscoring our point that allele-specific decay rates have substantial (yet underappreciated) impacts on shaping gene expression. (4/n)

We used Bru-seq/BruChase-seq data, which enables tracking the same population of RNA over time, to identify genes regulated by RNA stability. Our RNAtracker workflow employs a beta-binomial mixture model to categorize genes by their mode of regulation. (3/n)