Eachan Johnson
@eachan.scbir.org
Group leader at The Francis Crick Institute in London. Opinions are my own. he/him
🦠 M. tuberculosis, K. pneumoniae, other pathogenic bacteria
🧫 antimicrobial resistance
🧬 molecular genetics
⚗️ chemical biology
🦠 M. tuberculosis, K. pneumoniae, other pathogenic bacteria
🧫 antimicrobial resistance
🧬 molecular genetics
⚗️ chemical biology
Reposted by Eachan Johnson
www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!
Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com
PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com
www.findaphd.com
January 23, 2026 at 10:33 AM
www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!
Reposted by Eachan Johnson
We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing.
It’s not a toxin. It’s metabolism.
The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.
doi.org/10.1126/sciadv.aeb5297
It’s not a toxin. It’s metabolism.
The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.
doi.org/10.1126/sciadv.aeb5297
Enterococcus faecalis redox metabolism activates the unfolded protein response to impair wound healing
E. faecalis EET generates ROS, which induces the UPR in keratinocytes, inhibiting in vitro migration.
doi.org
January 17, 2026 at 1:26 AM
We’ve discovered how the superbug E. faecalis prevents chronic wounds from healing.
It’s not a toxin. It’s metabolism.
The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.
doi.org/10.1126/sciadv.aeb5297
It’s not a toxin. It’s metabolism.
The bacteria use extracellular electron transport (EET) to electrochemically generate ROS, effectively "freezing" skin cells in place.
doi.org/10.1126/sciadv.aeb5297
Reposted by Eachan Johnson
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
HLi Lab - Vacancies
Openings
hlilab.github.io
January 14, 2026 at 3:44 PM
I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated!
Reposted by Eachan Johnson
Collaboration of AI and wet experiments with high thoughput technology is the one of solution IMHO.
January 10, 2026 at 8:42 AM
Collaboration of AI and wet experiments with high thoughput technology is the one of solution IMHO.
Reposted by Eachan Johnson
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
www.nature.com
December 22, 2025 at 1:11 PM
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development.
www.nature.com/articles/s41...
A thread.
www.nature.com/articles/s41...
A thread.
Reposted by Eachan Johnson
"Across the highest adult performance, peak performance is negatively correlated with early performance" Is uite literally what you'd see if coliderbias:
December 20, 2025 at 4:10 PM
"Across the highest adult performance, peak performance is negatively correlated with early performance" Is uite literally what you'd see if coliderbias:
Reposted by Eachan Johnson
@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
December 20, 2025 at 11:34 PM
@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs
www.biorxiv.org/content/10.6...
Reposted by Eachan Johnson
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
www.science.org
December 20, 2025 at 11:49 PM
Multidisciplinary training, over time, produces the highest impact people
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Eachan Johnson
Light-activated metal complexes have been shown to disable antibiotic resistance enzymes in E. coli, significantly enhancing the effectiveness of existing antibiotics without harming human cells. doi.org/hbcxrb
How phototherapy could reverse antibiotic resistance
Lars Stevens-Cullinane works in a dark room. But he's not processing negatives and printing photographs on light-sensitive paper; he's testing whether brief flashes of light can make drug-resistant bacteria sensitive to antibiotics.
phys.org
November 28, 2025 at 2:30 PM
Light-activated metal complexes have been shown to disable antibiotic resistance enzymes in E. coli, significantly enhancing the effectiveness of existing antibiotics without harming human cells. doi.org/hbcxrb
Reposted by Eachan Johnson
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
November 10, 2025 at 11:11 AM
📣 Paper alert!
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today!
journals.biologists.com/dev/article/...
🚨Deadline for our Senior Scientist applications is next week.
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
The Francis Crick Institute hiring Senior Laboratory Research Scientist in London Area, United Kingdom | LinkedIn
Posted 2:43:22 PM. Senior Laboratory Research Scientist - Johnson LabDetails of the role:Reports to: Eachan Johnson…See this and similar jobs on LinkedIn.
www.linkedin.com
November 1, 2025 at 12:49 PM
🚨Deadline for our Senior Scientist applications is next week.
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
If you want to develop your academic career in London and help us tackle next-generation drug discovery for Gram-negative infections, apply!
Reposted by Eachan Johnson
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
October 27, 2025 at 2:07 PM
Crick group leaders work across disciplines, supported by core funding and mentoring to build ambitious, curiosity-driven research.
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Apply now to join us ➡️ www.crick.ac.uk/careers-stud...
Reposted by Eachan Johnson
Just a few weeks left to apply for our clinical PhD programme.
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
Doctoral clinical fellows
The Crick's clinical PhD programme.
www.crick.ac.uk
October 30, 2025 at 9:41 AM
Just a few weeks left to apply for our clinical PhD programme.
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
We're looking for clinicians who are passionate about research to join the 3-year fully funded programme.
Learn more and see what positions are available ⬇️
www.crick.ac.uk/careers-and-...
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
The Francis Crick Institute hiring Senior Laboratory Research Scientist in London Area, United Kingdom | LinkedIn
Posted 2:43:22 PM. Senior Laboratory Research Scientist - Johnson LabDetails of the role:Reports to: Eachan Johnson…See this and similar jobs on LinkedIn.
www.linkedin.com
October 24, 2025 at 3:25 PM
📢 We're searching for a PhD-level Senior Research Scientist to develop a next-generation antibacterial drug discovery strategy for Gram-negative infections.
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
If you're looking to combine CRISPRi and high-throughput assays, reach out to me by email or apply below.
www.linkedin.com/jobs/view/43...
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions.
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research.
Apply now ➡️ www.crick.ac.uk/careers-stud...
October 9, 2025 at 9:47 PM
Join our community of more than 120 ambitious research programmes in infectious disease, chemical biology, and many other areas of biomedicine - all under one roof with fantastic facilities and support.
Reposted by Eachan Johnson
We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad:
idm.uct.ac.za/media/739223
idm.uct.ac.za/media/739223
October 9, 2025 at 11:28 AM
We are inviting applications for postdoctoral fellows in immunology of TB at the South African Tuberculosis Vaccine Initiative, University of Cape Town. For more information see the attached ad:
idm.uct.ac.za/media/739223
idm.uct.ac.za/media/739223
Reposted by Eachan Johnson
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
October 5, 2025 at 4:10 PM
Dear #microbiology and #immunology community- I took a break from social media after I deleted my Twitter account, but am back here. Please help me rebuild my community by following me and amplifying this message- I will follow you back. Thank you and I look forward to our many interactions!
Reposted by Eachan Johnson
Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com
The NIH ordered me to stop my ‘dangerous’ gain-of-function research. It isn’t dangerous at all
Safe gain-of-function research is necessary to identify new treatments for diseases like for tuberculosis — but the NIH has imposed unfounded stops.
www.statnews.com
October 6, 2025 at 12:15 PM
Important piece from Sarah Stanley at Berkeley on new NIH definitions that can be construed to arbitrarily halt research that is both safe and important to public health and future cures www.statnews.com/2025/10/06/g... via @statnews.com
Reposted by Eachan Johnson
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery
Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...
chemrxiv.org
September 23, 2025 at 12:10 PM
🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...
📢 PhD Opportunity @crick.ac.uk
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
PhD students
Our PhD programme attracts the brightest scientific minds and is an opportunity for talented people to embark on their career in biomedical research.
www.crick.ac.uk
October 6, 2025 at 9:40 AM
📢 PhD Opportunity @crick.ac.uk
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Want to help fight against antimicrobial resistance? Join us in London! Open to international applicants.
We have non-clinical & clinical PhD positions to accelerate antibiotic discovery across bacterial species.
November deadlines. More details ⬇️🧵
Reposted by Eachan Johnson
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking - Nature Structural & Molecular Biology
By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding in...
www.nature.com
September 19, 2025 at 1:52 PM
Our article on human multidomain protein biogenesis is now published in @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Eachan Johnson
Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social
More info below ⬇️
More info below ⬇️
📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells
Guest Editors: Alex Hughes and Rashmi Priya
📅 Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
#DevBio
Guest Editors: Alex Hughes and Rashmi Priya
📅 Deadline: 1 March 2026
journals.biologists.com/dev/pages/ex...
#DevBio
September 19, 2025 at 9:48 AM
Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social
More info below ⬇️
More info below ⬇️
Reposted by Eachan Johnson
Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Systematic antigen selection is an enduring challenge in tuberculosis (TB) vaccine development. An antigen screen ranks protective CD4 T cell antigens and yields a novel trivalent mRNA vaccine that protects against TB challenges in mice.
dlvr.it
September 15, 2025 at 6:52 PM
Now online! Mining the CD4 antigen repertoire for next-generation tuberculosis vaccines
Reposted by Eachan Johnson
Be my colleague! Cal Poly San Luis Obispo is hiring two tenure-track positions for Fall 2026, chemical education and coatings technology.
Chen Ed: jobs.calpoly.edu/en-us/job/55...
Coatings: jobs.calpoly.edu/en-us/job/55...
Chen Ed: jobs.calpoly.edu/en-us/job/55...
Coatings: jobs.calpoly.edu/en-us/job/55...
Cal Poly - Details - Tenure Track Position - Chemistry
jobs.calpoly.edu
September 17, 2025 at 6:05 PM
Be my colleague! Cal Poly San Luis Obispo is hiring two tenure-track positions for Fall 2026, chemical education and coatings technology.
Chen Ed: jobs.calpoly.edu/en-us/job/55...
Coatings: jobs.calpoly.edu/en-us/job/55...
Chen Ed: jobs.calpoly.edu/en-us/job/55...
Coatings: jobs.calpoly.edu/en-us/job/55...
Reposted by Eachan Johnson
The EMBL PhD programme is open until 13th October (entry ~Sep 2026):
www.embl.org/about/info/e...
We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
www.embl.org/about/info/e...
We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
EMBL International PhD Programme – Unique in the world and waiting for you!
www.embl.org
September 17, 2025 at 3:49 PM
The EMBL PhD programme is open until 13th October (entry ~Sep 2026):
www.embl.org/about/info/e...
We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
www.embl.org/about/info/e...
We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them