And check this out - the capacity of these hearts to take up more energetic substrate - their mitochondrial flexibility - correlated with how much these hearts remodelled after 6 months of cardiac resynchronisation therapy.

For patients on an insulin-glucose infusion, switching on CRT shifted these patients to a greater proportion of lipid metabolism (the patients on a fat infusion presumably already maxed out!) [NEFA = non-esterified fatty acids]

We performed paired arteriovenous sampling on CRT implant patients while monitoring pressure volume loops and coronary artery flow

PPAR-gamma is closely involved in lipid metabolism (see Watson et al Circ 2023 for more on that in heart failure).
The footnote is that PPAR-gamma agonists (glitazones) are well known diabetic treatments but are contra-indicated in heart failure due to an oedema effect.

It's also (ironically) rejection of the idea that debate and discussion can refine an idea. No dissenting voices will be heard.

Work felt like the Christmas armistice in WW1. No shots fired, just people left to peacefully get on with their own thing. I wish it was always like this.

Assad day indeed.