•Creeping fat enriched with mechanosensitive CTHRC1+ fibroblasts
•CTHRC1+ fibroblasts localize to fibrotic niches at the CF-bowel wall interface
•CF-derived CTHRC1+ fibroblasts promote intestinal fibrosis via YAP/TAZ signaling
•Creeping fat enriched with mechanosensitive CTHRC1+ fibroblasts
•CTHRC1+ fibroblasts localize to fibrotic niches at the CF-bowel wall interface
•CF-derived CTHRC1+ fibroblasts promote intestinal fibrosis via YAP/TAZ signaling