This! Often a rare disease only occurs because the protein or gene is so critical. It typically suggests that understanding the mechanism will help us understand critical pathways.

Definitely. Sink my grant for whatever reason, but not this. But also, why isn't CIHR removing these comments?

Trying to get a diagnosis for a rare disease can be incredibly hard & take years. Sometimes the only hope is in the research.

Imagine what it must be like to read that your disease isn't worth funding because it doesn't affect enough people!

If I interpreted the other sections correctly a huge amount is going towards tax credits for IP and such. The insult IMO is constantly saying we're not innovative. We barely have enough funds to survive publish or perish but they think it's patent or perish.

The sad thing is they missed the point that a strong research environment attracts AND retains top talent.

Came here to see if I was interpreting this correctly. Seems like I am.

We used live-cell imaging with plus-end binding protein EB3 to determine microtubule polarity in astrocytes for the first time. They are ~88% plus-ends out.

3/x

I think I wrote, edited, & discarded several versions of the same skeet(?) this week.

I think the last version was.... this job is hard.

Some projects I was about to triage after years of work were suddenly revived this week & things feel a bit better.

Hope the tides change for you too!