Anne Carpenter
@drannecarpenter.bsky.social
Dedicated to drug discovery, enthralled by science. 5 kids. She. SAB Recursion. Founder SyzOnc. Lab at Broad Institute. Opinions my own.
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
October 10, 2025 at 4:47 PM
15 years in the making, we confirmed that mitochondria - the powerhouse of the cell - have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery… 🧵
Several successful medicines prove the principle: correcting protein mislocalization can be life-changing for patients. Pooled technology allows testing for treatments like this at scale!
Thanks to Taipale, Blainey, JT Neal labs for laying the foundation to make this kind of experiment possible.
Thanks to Taipale, Blainey, JT Neal labs for laying the foundation to make this kind of experiment possible.
August 5, 2025 at 12:06 PM
Several successful medicines prove the principle: correcting protein mislocalization can be life-changing for patients. Pooled technology allows testing for treatments like this at scale!
Thanks to Taipale, Blainey, JT Neal labs for laying the foundation to make this kind of experiment possible.
Thanks to Taipale, Blainey, JT Neal labs for laying the foundation to make this kind of experiment possible.
Have $10M and want to cure some diseases?
It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments.
Contact me - be a hero for desperate patients!
docs.google.com/document/d/1...
It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments.
Contact me - be a hero for desperate patients!
docs.google.com/document/d/1...
August 5, 2025 at 12:06 PM
Have $10M and want to cure some diseases?
It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments.
Contact me - be a hero for desperate patients!
docs.google.com/document/d/1...
It costs ~$1B to invent a new medicine…but $10M buys you Project Encore, to see if ANY existing drug might be repurposed for ~100 diseases that have no treatments.
Contact me - be a hero for desperate patients!
docs.google.com/document/d/1...
if you’re tired of Word/excel/PPT asking to save files to OneDrive and would rather default to your local computer, it’s in Preferences > Save - uncheck the top box
(whose wording sounds nothing like having this functionality)
(whose wording sounds nothing like having this functionality)
June 5, 2025 at 11:50 AM
if you’re tired of Word/excel/PPT asking to save files to OneDrive and would rather default to your local computer, it’s in Preferences > Save - uncheck the top box
(whose wording sounds nothing like having this functionality)
(whose wording sounds nothing like having this functionality)
Have you invented a liver cell/tissue model? Want to validate it for tox?
You can apply to test your model’s ability to detect liver toxicity mechanisms-OASIS Consortium will suggest subsets of compounds based on your system's scale; you run yr assay.
Email [email protected] for more!
pls RT!
You can apply to test your model’s ability to detect liver toxicity mechanisms-OASIS Consortium will suggest subsets of compounds based on your system's scale; you run yr assay.
Email [email protected] for more!
pls RT!
April 23, 2025 at 5:31 PM
Have you invented a liver cell/tissue model? Want to validate it for tox?
You can apply to test your model’s ability to detect liver toxicity mechanisms-OASIS Consortium will suggest subsets of compounds based on your system's scale; you run yr assay.
Email [email protected] for more!
pls RT!
You can apply to test your model’s ability to detect liver toxicity mechanisms-OASIS Consortium will suggest subsets of compounds based on your system's scale; you run yr assay.
Email [email protected] for more!
pls RT!
My startup SyzOnc was selected for the Recode Edge 2025 cohort - top 10 out of >200!
Thrilled to take part in this program run by
@vishalgulati.bsky.social and Armen Vidian focused on deep tech at the interface of machine learning and health. @recodeventures.bsky.social
Thanks also to sponsors!
Thrilled to take part in this program run by
@vishalgulati.bsky.social and Armen Vidian focused on deep tech at the interface of machine learning and health. @recodeventures.bsky.social
Thanks also to sponsors!
April 23, 2025 at 5:10 PM
My startup SyzOnc was selected for the Recode Edge 2025 cohort - top 10 out of >200!
Thrilled to take part in this program run by
@vishalgulati.bsky.social and Armen Vidian focused on deep tech at the interface of machine learning and health. @recodeventures.bsky.social
Thanks also to sponsors!
Thrilled to take part in this program run by
@vishalgulati.bsky.social and Armen Vidian focused on deep tech at the interface of machine learning and health. @recodeventures.bsky.social
Thanks also to sponsors!
As an academic who works on tech to discover causes and cures of disease, contributing to novel drugs reaching patients has been thrilling.
Thanks to @statnews.com naming me to STATUS List 2025 honoring leaders in health, medicine, and science!
#STATUSList
www.statnews.com/status-list/...
Thanks to @statnews.com naming me to STATUS List 2025 honoring leaders in health, medicine, and science!
#STATUSList
www.statnews.com/status-list/...
April 10, 2025 at 11:10 AM
As an academic who works on tech to discover causes and cures of disease, contributing to novel drugs reaching patients has been thrilling.
Thanks to @statnews.com naming me to STATUS List 2025 honoring leaders in health, medicine, and science!
#STATUSList
www.statnews.com/status-list/...
Thanks to @statnews.com naming me to STATUS List 2025 honoring leaders in health, medicine, and science!
#STATUSList
www.statnews.com/status-list/...
Or it can be behind a panel behind your calves (Model S) or behind the speaker grille in the door (Model X)
March 31, 2025 at 4:54 PM
Or it can be behind a panel behind your calves (Model S) or behind the speaker grille in the door (Model X)
Rear doors are much trickier (bad news for rideshare passengers and kids). Usually you are peeling some chunk of a car panel off to find a loop to pull.
Can be: under a panel in the lower storage compartment of the door (Model 3,Y,cybertruck-which has an additional rubber mat)...
Can be: under a panel in the lower storage compartment of the door (Model 3,Y,cybertruck-which has an additional rubber mat)...
March 31, 2025 at 4:54 PM
Rear doors are much trickier (bad news for rideshare passengers and kids). Usually you are peeling some chunk of a car panel off to find a loop to pull.
Can be: under a panel in the lower storage compartment of the door (Model 3,Y,cybertruck-which has an additional rubber mat)...
Can be: under a panel in the lower storage compartment of the door (Model 3,Y,cybertruck-which has an additional rubber mat)...
Front doors are pretty similar, there's a switch to pull up in front of the window switches for current Models S, X, Y, 3, cybertruck and old models are the same, or have regular door handles AFAICT. (alt text: pictures showing the switches)
March 31, 2025 at 4:54 PM
Front doors are pretty similar, there's a switch to pull up in front of the window switches for current Models S, X, Y, 3, cybertruck and old models are the same, or have regular door handles AFAICT. (alt text: pictures showing the switches)
@occlupanid.bsky.social
Hi! This is Anne’s daughter.
Dear HORG,
I am contacting you because I believe I have discovered a new species of occlupanopsida. This specimen differs from others in that it has a rectangular protrusion instead of palps and is made of cardboard.
Sincerely, Elle
Hi! This is Anne’s daughter.
Dear HORG,
I am contacting you because I believe I have discovered a new species of occlupanopsida. This specimen differs from others in that it has a rectangular protrusion instead of palps and is made of cardboard.
Sincerely, Elle
March 6, 2025 at 11:58 AM
@occlupanid.bsky.social
Hi! This is Anne’s daughter.
Dear HORG,
I am contacting you because I believe I have discovered a new species of occlupanopsida. This specimen differs from others in that it has a rectangular protrusion instead of palps and is made of cardboard.
Sincerely, Elle
Hi! This is Anne’s daughter.
Dear HORG,
I am contacting you because I believe I have discovered a new species of occlupanopsida. This specimen differs from others in that it has a rectangular protrusion instead of palps and is made of cardboard.
Sincerely, Elle
Awesome first day of my first JPM!
Meeting investors for SyzOnc in person, loving getting to know random ppl working on random things and I think I had a smore for dinner last night?
I always lose my voice at networking events so we brought throat soothers as swag 😀 #JPM2025
Meeting investors for SyzOnc in person, loving getting to know random ppl working on random things and I think I had a smore for dinner last night?
I always lose my voice at networking events so we brought throat soothers as swag 😀 #JPM2025
January 14, 2025 at 3:43 PM
Awesome first day of my first JPM!
Meeting investors for SyzOnc in person, loving getting to know random ppl working on random things and I think I had a smore for dinner last night?
I always lose my voice at networking events so we brought throat soothers as swag 😀 #JPM2025
Meeting investors for SyzOnc in person, loving getting to know random ppl working on random things and I think I had a smore for dinner last night?
I always lose my voice at networking events so we brought throat soothers as swag 😀 #JPM2025
Ok I had to look up how often this typo appears, but now I’m wondering… is “genome-wise” always a typo, or is it possible it mean something in some contexts??
December 30, 2024 at 12:43 PM
Ok I had to look up how often this typo appears, but now I’m wondering… is “genome-wise” always a typo, or is it possible it mean something in some contexts??
We've a postdoc opening for our lab at the Broad: Cambridge MA!
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
December 18, 2024 at 3:50 PM
We've a postdoc opening for our lab at the Broad: Cambridge MA!
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Must have experience in toxicology + data science
Work on the wonderful OASIS dataset we are producing... Cell Painting, transcriptomics, proteomics in various liver cell and tissue models!
broad.io/mlcbpostdoc
Highly recommend (long) read for anyone who's been leading a lab 10+ years!
December 9, 2024 at 4:24 PM
Highly recommend (long) read for anyone who's been leading a lab 10+ years!
We hypothesized new gene functions & confirmed some!
- TSC22D1 -> neural function
- ECH1, UQCRFS1, & SARS2 -> mito function & cancer
- solute carrier <-> olfactory receptor superfamilies
- INSYN1 -> cell migration/proliferation
- MYT1 txnally represses RNF41
- Hippo pathway
- TSC22D1 -> neural function
- ECH1, UQCRFS1, & SARS2 -> mito function & cancer
- solute carrier <-> olfactory receptor superfamilies
- INSYN1 -> cell migration/proliferation
- MYT1 txnally represses RNF41
- Hippo pathway
December 4, 2024 at 2:09 PM
We hypothesized new gene functions & confirmed some!
- TSC22D1 -> neural function
- ECH1, UQCRFS1, & SARS2 -> mito function & cancer
- solute carrier <-> olfactory receptor superfamilies
- INSYN1 -> cell migration/proliferation
- MYT1 txnally represses RNF41
- Hippo pathway
- TSC22D1 -> neural function
- ECH1, UQCRFS1, & SARS2 -> mito function & cancer
- solute carrier <-> olfactory receptor superfamilies
- INSYN1 -> cell migration/proliferation
- MYT1 txnally represses RNF41
- Hippo pathway
We found many already-known gene-gene connections: we quantified this against a knowledge graph: Gene pairs that are morphologically similar are more likely to be "known" correct in the knowledge graph (based on diverse human data sources).
We also presented some anecdotes.
We also presented some anecdotes.
December 4, 2024 at 2:09 PM
We found many already-known gene-gene connections: we quantified this against a knowledge graph: Gene pairs that are morphologically similar are more likely to be "known" correct in the knowledge graph (based on diverse human data sources).
We also presented some anecdotes.
We also presented some anecdotes.
What kinds of genes are more likely to produce a Cell Painting phenotype?
- essential genes & enzymes (for CRISPR, not ORF)
- disease-associated genes
- secreted proteins
- membrane proteins
- essential genes & enzymes (for CRISPR, not ORF)
- disease-associated genes
- secreted proteins
- membrane proteins
December 4, 2024 at 2:09 PM
What kinds of genes are more likely to produce a Cell Painting phenotype?
- essential genes & enzymes (for CRISPR, not ORF)
- disease-associated genes
- secreted proteins
- membrane proteins
- essential genes & enzymes (for CRISPR, not ORF)
- disease-associated genes
- secreted proteins
- membrane proteins
We tried a bunch of profile-processing approaches and validated the final profiles using several kinds of ground truth (not actual truth, just truthy!)
Example: 8% of CORUM protein complexes show significant img-based similarity among genes in that complex. 45% for Wikipathways!
Example: 8% of CORUM protein complexes show significant img-based similarity among genes in that complex. 45% for Wikipathways!
December 4, 2024 at 2:09 PM
We tried a bunch of profile-processing approaches and validated the final profiles using several kinds of ground truth (not actual truth, just truthy!)
Example: 8% of CORUM protein complexes show significant img-based similarity among genes in that complex. 45% for Wikipathways!
Example: 8% of CORUM protein complexes show significant img-based similarity among genes in that complex. 45% for Wikipathways!
So in the "Morph Map" paper, we tested ~75% of the protein-coding genome in human U-2 OS cells, by over expressing (ORF), knocking down (CRISPR ko) or both, and captured Cell Painting image-based profiles.
67% of the genes tested produced a Cell Painting phenotype!
67% of the genes tested produced a Cell Painting phenotype!
December 4, 2024 at 2:09 PM
So in the "Morph Map" paper, we tested ~75% of the protein-coding genome in human U-2 OS cells, by over expressing (ORF), knocking down (CRISPR ko) or both, and captured Cell Painting image-based profiles.
67% of the genes tested produced a Cell Painting phenotype!
67% of the genes tested produced a Cell Painting phenotype!
Holy smokes, such opportunity to invest in seed/preseed right now.
Investment is down 5-7% vs 2023 which was itself recognized as colossally terrible for fundraising.
December 1, 2024 at 8:53 PM
Holy smokes, such opportunity to invest in seed/preseed right now.
Investment is down 5-7% vs 2023 which was itself recognized as colossally terrible for fundraising.