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dragonscramble.bsky.social
sybil ΘΔ
@dragonscramble.bsky.social
250 followers 270 following 820 posts
23 // it/he // minors dni // ❤️ @ashleyninelives.bsky.social // BA in fucking your mom (and also psychology) 🐾 // pgh // pfp by mammalfriend
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dragonscramble.bsky.social
:0 omg bombo ...
November 29, 2025 at 4:40 PM
Reposted by sybil ΘΔ
sailorrooscout.bsky.social
Their efficacy was confirmed against LIVE viruses including Ebola, Marburg, Nipah, Hendra, SARS-CoV, SARS-CoV-2 (COVID-19), AND Middle East Respiratory Syndrome (MERS).

The study has been published in Science Advances. YES, it is PEER-REVIEWED.
• www.science.org/doi/10.1126/...

🧪🧵⬇️
ABSTRACT Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of universal drug targets across diverse viral families and high variability among viral proteins. In this study, we evaluated 57 synthetic carbohydrate receptors (SCRs) for antiviral activity in cellulo using pseudotyped virus particles (PVPs) from six high-risk viruses across three families: Paramyxoviridae, Filoviridae, and Coronaviridae. Four SCRs inhibited all tested PVPs, and their efficacy was confirmed against live viruses including SARS-CoV-2, MERS-COV, EBOV, MARV, NiV, and HeV. Notably, SCR005 and SCR007, which exhibited minimal toxicity, significantly reduced SARS-CoV-2 infection in a severe animal model with a single dose. Mechanistic studies suggested that SCRs bind viral envelope N-glycans, blocking viral attachment and/or fusion. These results identify conserved viral N-glycans as promising BSA targets and establish SCRs as candidate prophylactic agents against enveloped viruses with pandemic potential.
November 28, 2025 at 5:02 PM
dragonscramble.bsky.social
the freaky bathroom...
November 29, 2025 at 12:28 AM
dragonscramble.bsky.social
damn your two toilets have a different flush?? nuts
November 28, 2025 at 5:14 PM
dragonscramble.bsky.social
girl thats YOUR toilet

also iirc the bigger one is a smaller flush?
November 28, 2025 at 3:26 PM
dragonscramble.bsky.social
happy thanksgiving everybody
November 27, 2025 at 1:36 PM