Kevin Pruitt
@dr-kevin-pruitt.bsky.social
Associate Professor | UNC Chapel Hill, Pharmacology Department | Lineberger Comprehensive Cancer Center | Research in Endocrinology, Epigenetics, & Wnt signaling| Views my own. https://www.med.unc.edu/pharm/pruittlab/team/
Pinned
Kevin Pruitt
@dr-kevin-pruitt.bsky.social
· Nov 12
Hi Bluesky! As a first post, just sharing a few moments from our 1 yr anniversary since my lab relocated to UNC from Texas Tech. I love training the next generation of scientists & building teams that make discoveries in the fields of cancer biology and epigenetics. Excited to meet you on Bluesky!
Reposted by Kevin Pruitt
Had an amazing visit to the NIEHS to present the lab's research. The depth of expertise in #epigenetics and chromatin biology there is remarkable. Big thanks to @jxhoffman.bsky.social for hosting me. 🧪
November 22, 2025 at 2:17 PM
Had an amazing visit to the NIEHS to present the lab's research. The depth of expertise in #epigenetics and chromatin biology there is remarkable. Big thanks to @jxhoffman.bsky.social for hosting me. 🧪
Reposted by Kevin Pruitt
Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
RNA polymerase II coordinates histone deacetylation at active promoters
Transcription initiation limits histone acetylation and H2AZ incorporation at promoters.
www.science.org
February 12, 2025 at 9:21 PM
Unpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
www.science.org/doi/10.1126/...
Reposted by Kevin Pruitt
Gave a seminar at the Van Andel Institute and greatly enjoyed meeting with pioneers in the field of Wnt signaling @sgraingerphd.bsky.social and @bartwilliams.bsky.social. Also reunited with amazing colleagues in the fields of epigenetics and RAS biology. What a vibrant research community @vai.org!
September 23, 2025 at 10:43 PM
Gave a seminar at the Van Andel Institute and greatly enjoyed meeting with pioneers in the field of Wnt signaling @sgraingerphd.bsky.social and @bartwilliams.bsky.social. Also reunited with amazing colleagues in the fields of epigenetics and RAS biology. What a vibrant research community @vai.org!
Had an amazing visit to the NIEHS to present the lab's research. The depth of expertise in #epigenetics and chromatin biology there is remarkable. Big thanks to @jxhoffman.bsky.social for hosting me. 🧪
November 22, 2025 at 2:17 PM
Had an amazing visit to the NIEHS to present the lab's research. The depth of expertise in #epigenetics and chromatin biology there is remarkable. Big thanks to @jxhoffman.bsky.social for hosting me. 🧪
Reposted by Kevin Pruitt
For years, we searched for factors which are dysregulated in cancer and regulate development. We now describe elusive roles of DVL, a protein co-opted in #cancer and mutated in congenital disorders thanks to lab members & support from @unclineberger.bsky.social & @unc-phco.bsky.social
rdcu.be/ewwsZ
rdcu.be/ewwsZ
Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor
Nature Communications - Currently, nuclear roles for DVL1 and its involvement in gene regulation remained unclear. Here the authors reveal that altering DVL1 expression significantly reshapes gene...
rdcu.be
July 16, 2025 at 6:25 PM
For years, we searched for factors which are dysregulated in cancer and regulate development. We now describe elusive roles of DVL, a protein co-opted in #cancer and mutated in congenital disorders thanks to lab members & support from @unclineberger.bsky.social & @unc-phco.bsky.social
rdcu.be/ewwsZ
rdcu.be/ewwsZ
Reposted by Kevin Pruitt
Immense pride for the GW team (Chiappinelli, Seto & co.) pushing the frontier on cancer, immunity, and the dark genome. Their discoveries could revolutionize the treatment of stubborn tumors.
Read the full piece — this is science with real hope.
buff.ly/jTsiumZ
#GWCancerCenter #Epigenetics
Read the full piece — this is science with real hope.
buff.ly/jTsiumZ
#GWCancerCenter #Epigenetics
October 2, 2025 at 8:19 PM
Immense pride for the GW team (Chiappinelli, Seto & co.) pushing the frontier on cancer, immunity, and the dark genome. Their discoveries could revolutionize the treatment of stubborn tumors.
Read the full piece — this is science with real hope.
buff.ly/jTsiumZ
#GWCancerCenter #Epigenetics
Read the full piece — this is science with real hope.
buff.ly/jTsiumZ
#GWCancerCenter #Epigenetics
Reposted by Kevin Pruitt
This month we celebrated our 2nd yr since relocating to UNC and my final TTUHSC PhD defense of the talented Dr. Geetha Boligala, a thoughtful, creative, hard working, and brilliant lab member who's finalizing one of our most notable discoveries. She is simply amazing!
@geethapboligala.bsky.social
@geethapboligala.bsky.social
October 17, 2025 at 7:06 PM
This month we celebrated our 2nd yr since relocating to UNC and my final TTUHSC PhD defense of the talented Dr. Geetha Boligala, a thoughtful, creative, hard working, and brilliant lab member who's finalizing one of our most notable discoveries. She is simply amazing!
@geethapboligala.bsky.social
@geethapboligala.bsky.social
Reposted by Kevin Pruitt
The link for a junior tenure-track position with UNC-CH Biochemistry and Biophysics is now live. Learn about the search here www.med.unc.edu/biochem/join..., then apply here unc.peopleadmin.com/postings/307... Help us inspire tomorrow’s discoveries by decoding the molecular basis of life!
UNC Department of Biochemistry and Biophysics
Our mission is to perform transformative biochemical and biophysical research in an inclusive and stimulating training environment.
www.med.unc.edu
September 29, 2025 at 11:44 PM
The link for a junior tenure-track position with UNC-CH Biochemistry and Biophysics is now live. Learn about the search here www.med.unc.edu/biochem/join..., then apply here unc.peopleadmin.com/postings/307... Help us inspire tomorrow’s discoveries by decoding the molecular basis of life!
This month we celebrated our 2nd yr since relocating to UNC and my final TTUHSC PhD defense of the talented Dr. Geetha Boligala, a thoughtful, creative, hard working, and brilliant lab member who's finalizing one of our most notable discoveries. She is simply amazing!
@geethapboligala.bsky.social
@geethapboligala.bsky.social
October 17, 2025 at 7:06 PM
This month we celebrated our 2nd yr since relocating to UNC and my final TTUHSC PhD defense of the talented Dr. Geetha Boligala, a thoughtful, creative, hard working, and brilliant lab member who's finalizing one of our most notable discoveries. She is simply amazing!
@geethapboligala.bsky.social
@geethapboligala.bsky.social
Reposted by Kevin Pruitt
Congrats to Dr. Flavia Sardela de Miranda on her PhD defense! Smart, resilient, kind, hardworking, phenomenal lab member with amazing communication skills are just a few words that describe @flaviasardela.bsky.social. Your future is bright and you deserve the good coming your way. So proud of you!🎉
October 3, 2025 at 8:09 PM
Congrats to Dr. Flavia Sardela de Miranda on her PhD defense! Smart, resilient, kind, hardworking, phenomenal lab member with amazing communication skills are just a few words that describe @flaviasardela.bsky.social. Your future is bright and you deserve the good coming your way. So proud of you!🎉
Congrats to Dr. Flavia Sardela de Miranda on her PhD defense! Smart, resilient, kind, hardworking, phenomenal lab member with amazing communication skills are just a few words that describe @flaviasardela.bsky.social. Your future is bright and you deserve the good coming your way. So proud of you!🎉
October 3, 2025 at 8:09 PM
Congrats to Dr. Flavia Sardela de Miranda on her PhD defense! Smart, resilient, kind, hardworking, phenomenal lab member with amazing communication skills are just a few words that describe @flaviasardela.bsky.social. Your future is bright and you deserve the good coming your way. So proud of you!🎉
Reposted by Kevin Pruitt
🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…
September 27, 2025 at 2:13 PM
🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…
Gave a seminar at the Van Andel Institute and greatly enjoyed meeting with pioneers in the field of Wnt signaling @sgraingerphd.bsky.social and @bartwilliams.bsky.social. Also reunited with amazing colleagues in the fields of epigenetics and RAS biology. What a vibrant research community @vai.org!
September 23, 2025 at 10:43 PM
Gave a seminar at the Van Andel Institute and greatly enjoyed meeting with pioneers in the field of Wnt signaling @sgraingerphd.bsky.social and @bartwilliams.bsky.social. Also reunited with amazing colleagues in the fields of epigenetics and RAS biology. What a vibrant research community @vai.org!
Reposted by Kevin Pruitt
Big day for Bryjalab yesterday! Mirek Micka & Tomáš Gybeľ nailed their defences — welcome to the PhD club! 🎓🔥 Thanks to everyone who supported them along the way and came to celebrate! 🎉🤗
September 13, 2025 at 1:59 PM
Big day for Bryjalab yesterday! Mirek Micka & Tomáš Gybeľ nailed their defences — welcome to the PhD club! 🎓🔥 Thanks to everyone who supported them along the way and came to celebrate! 🎉🤗
Reposted by Kevin Pruitt
Congrats Ryan Woodring on your 1st author pub "Biodegradable nanofibrous scaffolds enhance standard of care for glioblastoma via localized targeted therapy"
Open Access: go.unc.edu/AinslieLabTMZ
Open Access: go.unc.edu/AinslieLabTMZ
September 13, 2025 at 3:03 PM
Congrats Ryan Woodring on your 1st author pub "Biodegradable nanofibrous scaffolds enhance standard of care for glioblastoma via localized targeted therapy"
Open Access: go.unc.edu/AinslieLabTMZ
Open Access: go.unc.edu/AinslieLabTMZ
Reposted by Kevin Pruitt
A moment from Day 1 of a symposium celebrating 50 yrs of discovery at UNC Lineberger Cancer Center. This talk by Dr. Edison Liu was one of many filled with inspiration and remarkable feats of scientific discovery.
@unclineberger.bsky.social
@unclineberger.bsky.social
September 10, 2025 at 1:55 AM
A moment from Day 1 of a symposium celebrating 50 yrs of discovery at UNC Lineberger Cancer Center. This talk by Dr. Edison Liu was one of many filled with inspiration and remarkable feats of scientific discovery.
@unclineberger.bsky.social
@unclineberger.bsky.social
A moment from Day 1 of a symposium celebrating 50 yrs of discovery at UNC Lineberger Cancer Center. This talk by Dr. Edison Liu was one of many filled with inspiration and remarkable feats of scientific discovery.
@unclineberger.bsky.social
@unclineberger.bsky.social
September 10, 2025 at 1:55 AM
A moment from Day 1 of a symposium celebrating 50 yrs of discovery at UNC Lineberger Cancer Center. This talk by Dr. Edison Liu was one of many filled with inspiration and remarkable feats of scientific discovery.
@unclineberger.bsky.social
@unclineberger.bsky.social
Reposted by Kevin Pruitt
Big thank you to Cristy Page, MD, MPH, Interim CEO and Dean, UNC Health and UNC School of Medicine, for stopping by the UNC Lineberger scientific symposium to speak to the scientists, clinicians, and advocates in attendance. unclineberger.org/symposium/
September 9, 2025 at 1:54 PM
Big thank you to Cristy Page, MD, MPH, Interim CEO and Dean, UNC Health and UNC School of Medicine, for stopping by the UNC Lineberger scientific symposium to speak to the scientists, clinicians, and advocates in attendance. unclineberger.org/symposium/
Reposted by Kevin Pruitt
We’re halfway through Day 1 of the UNC Lineberger Scientific Symposium, and what an inspiring morning it’s been! From powerful insights on cancer care, prevention, and biology—our speakers are delivering.
Onsite registration is open, or join us virtually anytime: unclineberger.org/symposium/
Onsite registration is open, or join us virtually anytime: unclineberger.org/symposium/
September 9, 2025 at 6:22 PM
We’re halfway through Day 1 of the UNC Lineberger Scientific Symposium, and what an inspiring morning it’s been! From powerful insights on cancer care, prevention, and biology—our speakers are delivering.
Onsite registration is open, or join us virtually anytime: unclineberger.org/symposium/
Onsite registration is open, or join us virtually anytime: unclineberger.org/symposium/
Reposted by Kevin Pruitt
Ever wondered what else SETD2 does beyond transcription? 🧬
Check out our new @natcellbio.nature.com study.
Awesome work from Abid Khan in the lab SETD2 moonlights during mitosis to keep the genome safe from chaos.showing how SETD2 moonlights to safeguard the genome during cell division.
Check out our new @natcellbio.nature.com study.
Awesome work from Abid Khan in the lab SETD2 moonlights during mitosis to keep the genome safe from chaos.showing how SETD2 moonlights to safeguard the genome during cell division.
August 11, 2025 at 12:26 PM
Ever wondered what else SETD2 does beyond transcription? 🧬
Check out our new @natcellbio.nature.com study.
Awesome work from Abid Khan in the lab SETD2 moonlights during mitosis to keep the genome safe from chaos.showing how SETD2 moonlights to safeguard the genome during cell division.
Check out our new @natcellbio.nature.com study.
Awesome work from Abid Khan in the lab SETD2 moonlights during mitosis to keep the genome safe from chaos.showing how SETD2 moonlights to safeguard the genome during cell division.
Reposted by Kevin Pruitt
August 31, 2025 at 9:40 PM
August 31, 2025 at 9:40 PM
Reposted by Kevin Pruitt
Welcomed the momentary peace of nature.
#trailwalk #gratitude #nature #bluesky #photography #summer #calm #peace
#trailwalk #gratitude #nature #bluesky #photography #summer #calm #peace
July 27, 2025 at 8:58 PM
Welcomed the momentary peace of nature.
#trailwalk #gratitude #nature #bluesky #photography #summer #calm #peace
#trailwalk #gratitude #nature #bluesky #photography #summer #calm #peace
Reposted by Kevin Pruitt
While helping my daughter move and get settled into her apartment for her senior year at UT Austin, we visited the Austin public library with her, where I took a photo from the top floor balcony of the library. My how time flies...
#Fatherhood #Memories #Austin #Texas #Longhorns #Bluesky #Clouds
#Fatherhood #Memories #Austin #Texas #Longhorns #Bluesky #Clouds
August 3, 2025 at 4:15 AM
While helping my daughter move and get settled into her apartment for her senior year at UT Austin, we visited the Austin public library with her, where I took a photo from the top floor balcony of the library. My how time flies...
#Fatherhood #Memories #Austin #Texas #Longhorns #Bluesky #Clouds
#Fatherhood #Memories #Austin #Texas #Longhorns #Bluesky #Clouds
While helping my daughter move and get settled into her apartment for her senior year at UT Austin, we visited the Austin public library with her, where I took a photo from the top floor balcony of the library. My how time flies...
#Fatherhood #Memories #Austin #Texas #Longhorns #Bluesky #Clouds
#Fatherhood #Memories #Austin #Texas #Longhorns #Bluesky #Clouds
August 3, 2025 at 4:15 AM
While helping my daughter move and get settled into her apartment for her senior year at UT Austin, we visited the Austin public library with her, where I took a photo from the top floor balcony of the library. My how time flies...
#Fatherhood #Memories #Austin #Texas #Longhorns #Bluesky #Clouds
#Fatherhood #Memories #Austin #Texas #Longhorns #Bluesky #Clouds