David Monchaud
@dmonchaud.bsky.social
🥖😬👨🎨 (France) - 🍯🍷🌧️ (Dijon) - 🧬🔬🧪 (CNRS)
GATTACA Lab. Chemical biology & genetics. Trying to understand why and how DNA and RNA fold into ωєιя∂ℓу ѕнαρє∂ structures..
https://sites.google.com/site/monchaudchembiolab/
GATTACA Lab. Chemical biology & genetics. Trying to understand why and how DNA and RNA fold into ωєιя∂ℓу ѕнαρє∂ structures..
https://sites.google.com/site/monchaudchembiolab/
Super proud of my team! They have simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s.
The TASQs story: doi.org/10.1021/acs....
This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...
The TASQs story: doi.org/10.1021/acs....
This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...
November 24, 2025 at 9:28 AM
Super proud of my team! They have simplified the synthesis of TASQs, enabling easier & faster access to these biomimetic G-quadruplex (G4) ligands used to image and identify cellular G4s.
The TASQs story: doi.org/10.1021/acs....
This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...
The TASQs story: doi.org/10.1021/acs....
This new article @chemistryeurope.bsky.social: doi.org/10.1002/chem...
A novel biotechnological application for G4s, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner
Now in Anal. Chem. @pubs.acs.org
With Nanjing U. & @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....
Now in Anal. Chem. @pubs.acs.org
With Nanjing U. & @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....
November 3, 2025 at 1:17 PM
A novel biotechnological application for G4s, used for controlling the activity of a CRISPR-Cas12a device used for diagnosing human viral infection (HPV) in a spatio-temporal manner
Now in Anal. Chem. @pubs.acs.org
With Nanjing U. & @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....
Now in Anal. Chem. @pubs.acs.org
With Nanjing U. & @polytechniqueparis.bsky.social
@cnrs.fr
doi.org/10.1021/acs....
The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down)
In ACS Bio & Med Chem Au: doi.org/10.1021/acsb...
With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)
In ACS Bio & Med Chem Au: doi.org/10.1021/acsb...
With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)
November 3, 2025 at 10:13 AM
The photoMultiTASQ is a new molecular tool to investigate G-quadruplex #G4 biology, notably for identifying G4 binding proteins by Chem-CLIP (chemical cross-linking and isolation by pull-down)
In ACS Bio & Med Chem Au: doi.org/10.1021/acsb...
With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)
In ACS Bio & Med Chem Au: doi.org/10.1021/acsb...
With @iphc-strasbourg.bsky.social (FR) & WIS Rehovot (IS)
Stimulating scientific days #ChemBioParis2025.
Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others
Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com
Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others
Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com
October 9, 2025 at 7:05 AM
Stimulating scientific days #ChemBioParis2025.
Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others
Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com
Super great to hear Shankar Balasubramanian speaking about G-quadruplex, Matthew Disney about ChemCLIP and Dan Nomura about MYC druggability, among many others
Kudos to @borisvauzeilles.bsky.social & the team for the organization chembioparis2025.com
Honored to have been interviewed by Pour La Science, a wide-audience scientific magazine, to discuss the results from @simonelsasser.bsky.social / @puckknipscheer.bsky.social published in @science.org about how DNA repair proteins mold G-quadruplex #G4
👉 tinyurl.com/3k6pxu6d
(sorry, in French only)
👉 tinyurl.com/3k6pxu6d
(sorry, in French only)
August 28, 2025 at 6:47 AM
Honored to have been interviewed by Pour La Science, a wide-audience scientific magazine, to discuss the results from @simonelsasser.bsky.social / @puckknipscheer.bsky.social published in @science.org about how DNA repair proteins mold G-quadruplex #G4
👉 tinyurl.com/3k6pxu6d
(sorry, in French only)
👉 tinyurl.com/3k6pxu6d
(sorry, in French only)
Happy to describe a novel strategy to detect pollutants in food with a super high sensitivity, using G-quadruplex #G4 based biosensing devices.
A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR)
Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....
A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR)
Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....
August 27, 2025 at 7:13 AM
Happy to describe a novel strategy to detect pollutants in food with a super high sensitivity, using G-quadruplex #G4 based biosensing devices.
A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR)
Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....
A collaboration with the University of Nanjing (CN) and Polytechnique Palaiseau (FR)
Now in Anal. Chem. (@pubs.acs.org): doi.org/10.1021/acs....
Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC.
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
August 26, 2025 at 6:41 AM
Happy to describe a novel strategy to combat colorectal cancer by pharmacologically modulating G-quadruplex #G4 RNA found in dysregulated lncRNAs, using the molecular helicase PhpC.
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
A collaboration with ITTGN (India) and supported by @embo.org fellowships
Now in BMC Biol.: doi.org/10.1186/s129...
A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) we developed in the lab
In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social
👉 doi.org/10.1016/j.ij...
In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social
👉 doi.org/10.1016/j.ij...
June 20, 2025 at 11:50 AM
A novel demonstration of the G-quadruplex #G4 unfolding properties of PhpC, a quite unique prototype of G4 unfolder (or molecular helicase) we developed in the lab
In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social
👉 doi.org/10.1016/j.ij...
In collaboration with C. Cruz @ubeirainterior.bsky.social and R.H.E. Huson @westernu.bsky.social
👉 doi.org/10.1016/j.ij...
The best of the best!
The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others
Thank you again for your participation!
The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others
Thank you again for your participation!
May 20, 2025 at 8:33 AM
The best of the best!
The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others
Thank you again for your participation!
The core of our community on #DNA #RNA junctions during the first meeting #IMAJ1 including @biometalusc.bsky.social, @sebastien-britton.bsky.social, @christinecardin.bsky.social, @granzhan.bsky.social, Jean-Louis, Mark and many others
Thank you again for your participation!
It was an absolute thrill and a real pleasure to organize the first meeting on #DNA #RNA junctions in Paris.
Fantastic talks, lively discussions—and some excellent wine too! 🍷😁
A very promising beginning for this new community
Stay tuned—we’ll be back next year!
#IMAJ1 #CNRSchimie @cnrs.fr
Fantastic talks, lively discussions—and some excellent wine too! 🍷😁
A very promising beginning for this new community
Stay tuned—we’ll be back next year!
#IMAJ1 #CNRSchimie @cnrs.fr
May 19, 2025 at 2:34 PM
It was an absolute thrill and a real pleasure to organize the first meeting on #DNA #RNA junctions in Paris.
Fantastic talks, lively discussions—and some excellent wine too! 🍷😁
A very promising beginning for this new community
Stay tuned—we’ll be back next year!
#IMAJ1 #CNRSchimie @cnrs.fr
Fantastic talks, lively discussions—and some excellent wine too! 🍷😁
A very promising beginning for this new community
Stay tuned—we’ll be back next year!
#IMAJ1 #CNRSchimie @cnrs.fr
We're thrilled to have contributed to this @naturecomms.bsky.social paper on the role of G-quadruplex #G4 in mitochondrial RNA
G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate
This is huge!
👉 doi.org/10.1038/s414...
G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate
This is huge!
👉 doi.org/10.1038/s414...
April 7, 2025 at 1:59 PM
We're thrilled to have contributed to this @naturecomms.bsky.social paper on the role of G-quadruplex #G4 in mitochondrial RNA
G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate
This is huge!
👉 doi.org/10.1038/s414...
G4s can be targeted with ligands to inhibit mitochondrial translation and eventually functions, which jeopardizes cancer cells fate
This is huge!
👉 doi.org/10.1038/s414...
Welcome to BlueSky @jamchemsoc.bsky.social !
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
March 11, 2025 at 10:36 AM
Welcome to BlueSky @jamchemsoc.bsky.social !
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
Happy to celebrate your arrival amongst us with this new article (doi.org/10.1021/jacs...), in which we report on CoRP-seq, a technique for mapping RNA G-quadruplex #G4 transcriptome-wide in a fast, cheap and simple manner
#chembio #AcademicSky #SciSky
A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
January 22, 2025 at 7:56 AM
A fully detailed protocol to visualize G-quadruplex #G4 DNA/RNA in human cells using clickable G4 ligands (in situ click imaging) now in @bio-protocol.bsky.social
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
Interested?? All you need is:
- the clickable ligand: www.sigmaaldrich.com/FR/en/produc...
- and the protocol: doi.org/10.21769/Bio...
Quite happy to see this out in @chemistryeurope.bsky.social (with ENS Paris FR, Szeged University HU, UTC Prague CZ)
We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties.
👉 doi.org/10.1002/cmdc...
We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties.
👉 doi.org/10.1002/cmdc...
January 15, 2025 at 1:14 PM
Quite happy to see this out in @chemistryeurope.bsky.social (with ENS Paris FR, Szeged University HU, UTC Prague CZ)
We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties.
👉 doi.org/10.1002/cmdc...
We report here on molecular tools used to detect G-quadruplex #G4 DNA/RNA in vitro, and on the mechanism underlying their unique photophysical properties.
👉 doi.org/10.1002/cmdc...
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
December 11, 2024 at 9:14 AM
A fully detailed method (40+ steps) to isolate/identify RNA G-quadruplex #G4 in human cells using G4-RNA precipitation (G4RP) protocol
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
G4RP.v1 in @natureportfolio.bsky.social: doi.org/10.1038/s414... & nature.com/articles/s41...
& G4RP.v2 now in @cellpressnews.bsky.social: doi.org/10.1016/j.xp...
One of the ones I am most proud of.
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
December 3, 2024 at 10:33 AM
One of the ones I am most proud of.
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
In this article, we abided by the very definition of chemical biology #ChemBio to decipher the role that DNA/RNA G-quadruplex #G4 plays, and the effects that the G4 ligands have, in human cells.
👉https://dx.doi.org/10.1016/j.jbc.2024.108040
@cnrs.bsky.social
My (little) contribution to make the field of G-quadruplex #G4 ligands accessible to all..
.. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology.
A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉
👉 doi.org/10.1007/s000...
.. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology.
A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉
👉 doi.org/10.1007/s000...
November 27, 2024 at 9:40 AM
My (little) contribution to make the field of G-quadruplex #G4 ligands accessible to all..
.. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology.
A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉
👉 doi.org/10.1007/s000...
.. and to show how pivotal ligands have been as #ChemBio tools to decipher G4 biology.
A personal view on the contribution of Pr. Stephen Neidle in a Sp. Issue honoring S. Neidle 😉
👉 doi.org/10.1007/s000...
Kane is an artist, his work deserves to be highlighted ;-) this one is also one of his masterpieces
November 17, 2024 at 9:11 AM
Kane is an artist, his work deserves to be highlighted ;-) this one is also one of his masterpieces
Hi DNA/RNA folks!
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested
November 14, 2024 at 10:39 AM
Hi DNA/RNA folks!
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested
With @granzhan.bsky.social @sebastien-britton.bsky.social @glowsticks.bsky.social and others we are launching an International Research Network (IRN) on nucleic acid junctions #3WJ - Thanks @cnrs.bsky.social Chimie!
1st meeting next year (May 25) in Paris
Contact me if interested
(4/4) With my buddies @sebastien-britton.bsky.social and @granzhan.bsky.social we are currently designing, synthesizing and using small molecules aimed at interacting with alternative DNA and RNA structures (mostly three-way junctions #3WJ and G-quadruplex #G4) to decipher their cellular biology
November 13, 2024 at 7:31 AM
(4/4) With my buddies @sebastien-britton.bsky.social and @granzhan.bsky.social we are currently designing, synthesizing and using small molecules aimed at interacting with alternative DNA and RNA structures (mostly three-way junctions #3WJ and G-quadruplex #G4) to decipher their cellular biology
(3/4) ..or the use of chemicals "to interrogate, modify, and manipulate biological systems
at the cellular level in a highly controlled manner"
(Karl-Heinz Altmann, ChemBioChem 2009, 10, 16)
at the cellular level in a highly controlled manner"
(Karl-Heinz Altmann, ChemBioChem 2009, 10, 16)
November 13, 2024 at 7:31 AM
(3/4) ..or the use of chemicals "to interrogate, modify, and manipulate biological systems
at the cellular level in a highly controlled manner"
(Karl-Heinz Altmann, ChemBioChem 2009, 10, 16)
at the cellular level in a highly controlled manner"
(Karl-Heinz Altmann, ChemBioChem 2009, 10, 16)
(2/4) Then, the definition has evolved towards a more general notion involving the use of chemicals "as reversible modulators of biological systems to gain a deep understanding of cell circuitry and diseases biology"
(Stuart L. Schreiber, Nat. Chem. Biol. 2005, 1, 64)..
(Stuart L. Schreiber, Nat. Chem. Biol. 2005, 1, 64)..
November 13, 2024 at 7:31 AM
(2/4) Then, the definition has evolved towards a more general notion involving the use of chemicals "as reversible modulators of biological systems to gain a deep understanding of cell circuitry and diseases biology"
(Stuart L. Schreiber, Nat. Chem. Biol. 2005, 1, 64)..
(Stuart L. Schreiber, Nat. Chem. Biol. 2005, 1, 64)..
So let's talk about chemical biology! But what is it all about exactly? A thread (1/4)
The notion of chemical biology (and of chemical genetics) was initially discussed between Linus Pauling and George Beadle as of 1945 and published in 1954
(Eng. Sci. 1954, 17, 9)
The notion of chemical biology (and of chemical genetics) was initially discussed between Linus Pauling and George Beadle as of 1945 and published in 1954
(Eng. Sci. 1954, 17, 9)
November 13, 2024 at 7:31 AM
So let's talk about chemical biology! But what is it all about exactly? A thread (1/4)
The notion of chemical biology (and of chemical genetics) was initially discussed between Linus Pauling and George Beadle as of 1945 and published in 1954
(Eng. Sci. 1954, 17, 9)
The notion of chemical biology (and of chemical genetics) was initially discussed between Linus Pauling and George Beadle as of 1945 and published in 1954
(Eng. Sci. 1954, 17, 9)