Ährlund-Richter et al. show that in mice, discrete subregions of the prefrontal cortex send distinct feedback signals to the primary visual cortex. These pathways differentially modulate visual proces...

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Apply. The 2026 Leading Edge cohort application is now open! This cohort is named the Zara Weinberg Cohort, in honor of 2021 Leading Edge Fellow, Zara Weinberg. Applications are due February 2, 2026.

Perceptual experience depends on recurrent interactions between lower and higher cortices. One theory, predictive coding, posits that feedback from higher to lower brain regions decreases neuronal activity predicted by higher-level representations. Despite the widespread adoption of predictive coding in neuroscience, the correspondence to neurophysiological findings in sensory cortices remains elusive. Here, we review how the canonical patterns of intra- and inter-cortical interactions that occur during perception and shifts of attention deviate from those predicted by predictive coding. We argue that these circuit interactions are better captured by alternative theories, which we summarize under the umbrella term BELIEF. We review how BELIEF theories account for the inter-areal interactions during attentive perception.

This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

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By a vote of 5-4, the Supreme Court on Thursday agreed to allow the National Institutes of Health, the largest public funding source for biomedical research in the world, to […]