Debora Gisch
@dlgisch.bsky.social
🔬 Assistant Research Professor @ IU School of Medicine | Division of Clinical Pharmacology
I am a bioinformatician specializing in snRNA-seq, scATAC-seq, and DNA methylation analysis to understand biomolecular changes during DDI trials.
I am a bioinformatician specializing in snRNA-seq, scATAC-seq, and DNA methylation analysis to understand biomolecular changes during DDI trials.
Pinned
Cannabidiol is used off-label for chronic pain, yet little is known about its immune system effects in transplant recipients.
Here, ASCI member Gisch et al. report CBD exerts anti-inflammatory effects but maintains T effector memory cell differentiation in humans: doi.org/10.1172/jci....
Here, ASCI member Gisch et al. report CBD exerts anti-inflammatory effects but maintains T effector memory cell differentiation in humans: doi.org/10.1172/jci....
Proud to share that our human clinical trial on CBD and immune function is now published!
Led by Dr. Michael Eadon (Clinical Pharmacology Division, Indiana University School of Medicine) and honored to contribute as author.
This is the 5th paper from this clinical trial.
Led by Dr. Michael Eadon (Clinical Pharmacology Division, Indiana University School of Medicine) and honored to contribute as author.
This is the 5th paper from this clinical trial.
Proud to share that our human clinical trial on CBD and immune function is now published!
Led by Dr. Michael Eadon (Clinical Pharmacology Division, Indiana University School of Medicine) and honored to contribute as author.
This is the 5th paper from this clinical trial.
Led by Dr. Michael Eadon (Clinical Pharmacology Division, Indiana University School of Medicine) and honored to contribute as author.
This is the 5th paper from this clinical trial.
Cannabidiol is used off-label for chronic pain, yet little is known about its immune system effects in transplant recipients.
Here, ASCI member Gisch et al. report CBD exerts anti-inflammatory effects but maintains T effector memory cell differentiation in humans: doi.org/10.1172/jci....
Here, ASCI member Gisch et al. report CBD exerts anti-inflammatory effects but maintains T effector memory cell differentiation in humans: doi.org/10.1172/jci....
January 21, 2026 at 1:50 AM
Proud to share that our human clinical trial on CBD and immune function is now published!
Led by Dr. Michael Eadon (Clinical Pharmacology Division, Indiana University School of Medicine) and honored to contribute as author.
This is the 5th paper from this clinical trial.
Led by Dr. Michael Eadon (Clinical Pharmacology Division, Indiana University School of Medicine) and honored to contribute as author.
This is the 5th paper from this clinical trial.
Reposted by Debora Gisch
🚨 Preprint Alert! 🚨
We’re thrilled to share our long-awaited #Atlas 2.0 manuscript:
“Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney” is now live on bioRxiv!
📄 Read the full preprint: www.biorxiv.org/content/10.1...
We’re thrilled to share our long-awaited #Atlas 2.0 manuscript:
“Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney” is now live on bioRxiv!
📄 Read the full preprint: www.biorxiv.org/content/10.1...
www.biorxiv.org
September 29, 2025 at 2:51 PM
🚨 Preprint Alert! 🚨
We’re thrilled to share our long-awaited #Atlas 2.0 manuscript:
“Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney” is now live on bioRxiv!
📄 Read the full preprint: www.biorxiv.org/content/10.1...
We’re thrilled to share our long-awaited #Atlas 2.0 manuscript:
“Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney” is now live on bioRxiv!
📄 Read the full preprint: www.biorxiv.org/content/10.1...
Reposted by Debora Gisch
📑 Need something to read this weekend? If so, you're in luck!
"Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules" fueled by #KPMP investigators is hot off the press today @science.org
www.science.org/doi/10.1126/...
"Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules" fueled by #KPMP investigators is hot off the press today @science.org
www.science.org/doi/10.1126/...
Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules
The interplay in expression of the stem cell markers THY1 and PROM1 in kidney proximal tubules marks the timeline of disease.
www.science.org
August 15, 2025 at 8:15 PM
📑 Need something to read this weekend? If so, you're in luck!
"Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules" fueled by #KPMP investigators is hot off the press today @science.org
www.science.org/doi/10.1126/...
"Integration of spatial protein imaging and transcriptomics in the human kidney tracks the regenerative potential of proximal tubules" fueled by #KPMP investigators is hot off the press today @science.org
www.science.org/doi/10.1126/...
What does CBD really do to the immune system in humans?
🧬 We gave healthy adults oral cannabidiol oil.
📉 Lymphocyte proliferation dropped.
🔥 Inflammatory signals shifted.
💡 T effector memory cells expanded.
Preprint out now:
🔗 www.biorxiv.org/content/10.1...
#CBD #scRNAseq #Immunology #pk
🧬 We gave healthy adults oral cannabidiol oil.
📉 Lymphocyte proliferation dropped.
🔥 Inflammatory signals shifted.
💡 T effector memory cells expanded.
Preprint out now:
🔗 www.biorxiv.org/content/10.1...
#CBD #scRNAseq #Immunology #pk
Cannabidiol exerts anti-inflammatory effects but maintains T effector memory cell differentiation: A Single-Cell Study in Humans
Cannabidiol is widely available and often used for pain management. Individuals with kidney disease or renal allografts have limited analgesia options. We conducted a Phase 1 human study to compare th...
www.biorxiv.org
August 5, 2025 at 1:07 AM
What does CBD really do to the immune system in humans?
🧬 We gave healthy adults oral cannabidiol oil.
📉 Lymphocyte proliferation dropped.
🔥 Inflammatory signals shifted.
💡 T effector memory cells expanded.
Preprint out now:
🔗 www.biorxiv.org/content/10.1...
#CBD #scRNAseq #Immunology #pk
🧬 We gave healthy adults oral cannabidiol oil.
📉 Lymphocyte proliferation dropped.
🔥 Inflammatory signals shifted.
💡 T effector memory cells expanded.
Preprint out now:
🔗 www.biorxiv.org/content/10.1...
#CBD #scRNAseq #Immunology #pk
Reposted by Debora Gisch
Are you an artist inspired by the world of biology? The Science Museum in London is inviting proposals for an art commission that will explore and showcase the themes raised by the Human Cell Atlas. Find out more:
Human Cell Atlas Creative Commission for the Tomorrow Gallery [Notice]
Introduction : Tomorrow: The Bennett Gallery will be the Science Museum's new landmark gallery expl... A Tender Notice by Science Museum Group. Value £0-£100K.
buff.ly
March 7, 2025 at 4:10 PM
Are you an artist inspired by the world of biology? The Science Museum in London is inviting proposals for an art commission that will explore and showcase the themes raised by the Human Cell Atlas. Find out more:
Last day at Kidney Week! Thank you for all the opportunities to learn and exchange experiences! #KidneyWk San Diego, CA 2024
Hope to see you all next year in Houston, TX!"
Hope to see you all next year in Houston, TX!"
October 27, 2024 at 4:28 PM
Last day at Kidney Week! Thank you for all the opportunities to learn and exchange experiences! #KidneyWk San Diego, CA 2024
Hope to see you all next year in Houston, TX!"
Hope to see you all next year in Houston, TX!"
Reposted by Debora Gisch
A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1
A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1
Background: The maintenance of a healthy epithelial-endothelial juxtaposition requires cross-talk wi
www.biorxiv.org
September 30, 2024 at 5:30 PM
A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1
Reposted by Debora Gisch
A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1
A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1
Background: The maintenance of a healthy epithelial-endothelial juxtaposition requires cross-talk wi
www.biorxiv.org
September 30, 2024 at 5:30 PM
A MEF2C transcripton factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease https://www.biorxiv.org/content/10.1101/2024.09.27.615250v1