Karen Dixon
@dixon-lab.bsky.social
Cancer Immunology Lab in Basel 🇨🇭.
Reposted by Karen Dixon
@dixon-lab.bsky.social, Gonzalo Fernandez Lahore, & @kuchroolab.bsky.social discuss the emerging roles for #TIM3 in regulating #MyeloidCell #immune responses!
Beyond T cell exhaustion: TIM-3 regulation of myeloid cells
We provide a comprehensive review of 20 years of research on TIM-3 functions in myeloid cells and T cell exhaustion.
www.science.org
April 29, 2025 at 12:52 PM
@dixon-lab.bsky.social, Gonzalo Fernandez Lahore, & @kuchroolab.bsky.social discuss the emerging roles for #TIM3 in regulating #MyeloidCell #immune responses!
Tremendously honoured to be recognised by the AACR among these fantastic scientists - Can't wait to hear more about the phenomenal work is doing! #AACR25 @theaacr.bsky.social
This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...
April 27, 2025 at 1:28 PM
Tremendously honoured to be recognised by the AACR among these fantastic scientists - Can't wait to hear more about the phenomenal work is doing! #AACR25 @theaacr.bsky.social
Reposted by Karen Dixon
Grateful to share our study on the potential for immune checkpoint blockade in late-onset #AlzheimersDisease out @nature.com today. Co-led with Kimi, Zhuoran, Ahad @kuchroolab.bsky.social in a big team effort @genelayinstitute.bsky.social @broadinstitute.org @harvardmed.bsky.social /1
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease - Nature
The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.
www.nature.com
April 10, 2025 at 3:39 AM
Grateful to share our study on the potential for immune checkpoint blockade in late-onset #AlzheimersDisease out @nature.com today. Co-led with Kimi, Zhuoran, Ahad @kuchroolab.bsky.social in a big team effort @genelayinstitute.bsky.social @broadinstitute.org @harvardmed.bsky.social /1
Reposted by Karen Dixon
academic.oup.com/sleep/advanc... excited to share our lab’s first data paper, led by stellar lab tech Leah Boyd in a fun collab with @erinmgibson.bsky.social :) one step closer to understanding and combating chemotherapy-associated behavioral comorbidities.
Enduring NREM sleep fragmentation following methotrexate chemotherapy in cancer-naïve mice
AbstractStudy objectives. Sleep disruption is common in people with cancer and survivors, but understanding the mechanisms driving these problems is diffic
academic.oup.com
March 20, 2025 at 2:39 PM
academic.oup.com/sleep/advanc... excited to share our lab’s first data paper, led by stellar lab tech Leah Boyd in a fun collab with @erinmgibson.bsky.social :) one step closer to understanding and combating chemotherapy-associated behavioral comorbidities.
Reposted by Karen Dixon
A great collab with @jborniger.bsky.social lab showing persistent NREM sleep disturbances with chemotherapy exposure irrespective of cancer presence. Important work in our understanding of how cancer treatments can impart lasting neurological changes.
academic.oup.com/sleep/advanc... excited to share our lab’s first data paper, led by stellar lab tech Leah Boyd in a fun collab with @erinmgibson.bsky.social :) one step closer to understanding and combating chemotherapy-associated behavioral comorbidities.
Enduring NREM sleep fragmentation following methotrexate chemotherapy in cancer-naïve mice
AbstractStudy objectives. Sleep disruption is common in people with cancer and survivors, but understanding the mechanisms driving these problems is diffic
academic.oup.com
March 20, 2025 at 3:07 PM
A great collab with @jborniger.bsky.social lab showing persistent NREM sleep disturbances with chemotherapy exposure irrespective of cancer presence. Important work in our understanding of how cancer treatments can impart lasting neurological changes.
Reposted by Karen Dixon
Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...
Open access link:
www.nature.com/articles/s41...
February 19, 2025 at 9:41 PM
Delighted to share the published version of this work from brilliant #CancerNeuroscience post-doc Tara Barron detailing GABAergic neuron-to-glioma synapses in #DIPG/#DMG. 🧵
Open access link:
www.nature.com/articles/s41...
Open access link:
www.nature.com/articles/s41...
Reposted by Karen Dixon
Our paper in @nature.com is finally published: a prospective trial of a personalized Neoantigen Vaccine in Kidney Cancer
www.nature.com/articles/s41...
This is teamwork with @danafarber.bsky.social @yalecancer.bsky.social @harvardmed.bsky.social + Wu lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This is teamwork with @danafarber.bsky.social @yalecancer.bsky.social @harvardmed.bsky.social + Wu lab
www.nature.com/articles/s41...
February 5, 2025 at 7:18 PM
Our paper in @nature.com is finally published: a prospective trial of a personalized Neoantigen Vaccine in Kidney Cancer
www.nature.com/articles/s41...
This is teamwork with @danafarber.bsky.social @yalecancer.bsky.social @harvardmed.bsky.social + Wu lab
www.nature.com/articles/s41...
www.nature.com/articles/s41...
This is teamwork with @danafarber.bsky.social @yalecancer.bsky.social @harvardmed.bsky.social + Wu lab
www.nature.com/articles/s41...
Reposted by Karen Dixon
📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells.
authors.elsevier.com/sd/article/S...
#neurobiology
authors.elsevier.com/sd/article/S...
#neurobiology
January 30, 2025 at 2:29 PM
📢New publication out: Sensory Neurotransmission and Pain in Solid Tumor Progression! This review article by first author @andremartel.bsky.social details recent work on the bidirectional relationship between sensory neurons and #cancer cells.
authors.elsevier.com/sd/article/S...
#neurobiology
authors.elsevier.com/sd/article/S...
#neurobiology