David Helekal
@dhelekal.bsky.social
Trees, Pathogens, Bayes.
Current: Postdoc @ Harvard Chan SPH
Prev: PhD @ Warwick
Current: Postdoc @ Harvard Chan SPH
Prev: PhD @ Warwick
Reposted by David Helekal
Now out in NEJM. Kudos to @dhelekal.bsky.social and @tatumdmortimer.bsky.social : www.nejm.org/doi/10.1056/...
July 10, 2025 at 11:09 AM
Now out in NEJM. Kudos to @dhelekal.bsky.social and @tatumdmortimer.bsky.social : www.nejm.org/doi/10.1056/...
Reposted by David Helekal
If you are an early career research attending @stihiv2025.org and interested in learning more about data visualization in R, @odileharrison.bsky.social , Sim Dabee, and I are organizing a workshop during the conference (11:30am-1:30pm on Wednesday). Register here: forms.gle/e4UL1NG62PUD...
ECR Data Visualisation Workshop
Please complete this application to attend the Data Viz workshop. This event will be held at the 2025 STI & HIV World Congress in Montreal, Canada on Wednesday, July 30th from 11:30-13:30.
Effective...
forms.gle
June 26, 2025 at 2:12 PM
If you are an early career research attending @stihiv2025.org and interested in learning more about data visualization in R, @odileharrison.bsky.social , Sim Dabee, and I are organizing a workshop during the conference (11:30am-1:30pm on Wednesday). Register here: forms.gle/e4UL1NG62PUD...
Reposted by David Helekal
A fun conversation with Carl this afternoon about his excellent book AIR-BORNE--the recording is available at the HSPH youtube site: www.youtube.com/user/Harvard...
June 24, 2025 at 8:56 PM
A fun conversation with Carl this afternoon about his excellent book AIR-BORNE--the recording is available at the HSPH youtube site: www.youtube.com/user/Harvard...
Reposted by David Helekal
One ceftriaxone-resistant #typhoid case last year set us on a path that is now live on Emerging Infectious Diseases.
47 cases in months, resistance rose from 0 to 5%. We spoke with patients, sequenced samples. 4.3.1.2.B1 lineage+blaCTX-M-15 on pCROB1. #AMR #PublicHealth
wwwnc.cdc.gov/eid/article/...
47 cases in months, resistance rose from 0 to 5%. We spoke with patients, sequenced samples. 4.3.1.2.B1 lineage+blaCTX-M-15 on pCROB1. #AMR #PublicHealth
wwwnc.cdc.gov/eid/article/...
Outbreak of Ceftriaxone-Resistant <em>Salmonella enterica</em> Serovar Typhi, Bangladesh, 2024
Ceftriaxone-Resistant <em>Salmonella</em> Typhi, Bangladesh
wwwnc.cdc.gov
June 23, 2025 at 4:19 PM
One ceftriaxone-resistant #typhoid case last year set us on a path that is now live on Emerging Infectious Diseases.
47 cases in months, resistance rose from 0 to 5%. We spoke with patients, sequenced samples. 4.3.1.2.B1 lineage+blaCTX-M-15 on pCROB1. #AMR #PublicHealth
wwwnc.cdc.gov/eid/article/...
47 cases in months, resistance rose from 0 to 5%. We spoke with patients, sequenced samples. 4.3.1.2.B1 lineage+blaCTX-M-15 on pCROB1. #AMR #PublicHealth
wwwnc.cdc.gov/eid/article/...
Reposted by David Helekal
Looking forward to my visit @ccdd-hsph.bsky.social!
March 31, 2025 at 8:47 PM
Looking forward to my visit @ccdd-hsph.bsky.social!
(1/10) New preprint: Expansion of tetM-carrying Neisseria gonorrhoeae in the US, 2018-2024; Link: www.medrxiv.org/content/10.1...
March 28, 2025 at 8:43 PM
(1/10) New preprint: Expansion of tetM-carrying Neisseria gonorrhoeae in the US, 2018-2024; Link: www.medrxiv.org/content/10.1...
How do changes in antibiotic use, various pathways to resistance, multiple drug resistance, and more come together to shape the success and failure of bacterial lineages in a real-world epidemic? #AMR #microsky
A preprint: www.biorxiv.org/content/10.1...
(1/15)
A preprint: www.biorxiv.org/content/10.1...
(1/15)
Quantifying the impact of antibiotic use and genetic determinants of resistance on bacterial lineage dynamics
The dynamics of antimicrobial resistance in bacteria are informed by the fitness advantages conferred by genetic determinants of resistance in the presence of antibiotic pressure and the potential fit...
www.biorxiv.org
February 7, 2025 at 9:58 PM
How do changes in antibiotic use, various pathways to resistance, multiple drug resistance, and more come together to shape the success and failure of bacterial lineages in a real-world epidemic? #AMR #microsky
A preprint: www.biorxiv.org/content/10.1...
(1/15)
A preprint: www.biorxiv.org/content/10.1...
(1/15)
Reposted by David Helekal
SAVE THE DATE ‼️ 📆 📢
BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Petra Levin as keynote! We can't wait to see you there.
Registration and scholarship applications open next week.
BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Petra Levin as keynote! We can't wait to see you there.
Registration and scholarship applications open next week.
February 1, 2025 at 3:05 PM
SAVE THE DATE ‼️ 📆 📢
BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Petra Levin as keynote! We can't wait to see you there.
Registration and scholarship applications open next week.
BBM 2025 will be held on June 9-10th at the Harvard Science Center feat. the one and only Dr. Petra Levin as keynote! We can't wait to see you there.
Registration and scholarship applications open next week.
Reposted by David Helekal
Why don’t people who live together have the same strains of microbes? Tami Lieberman (@contaminatedsci.bsky.social) and I put forward one underexplored reason in our new preprint:
Intraspecies warfare restricts strain coexistence in human skin microbiomes
Intraspecies warfare restricts strain coexistence in human skin microbiomes
Intraspecies warfare restricts strain coexistence in human skin microbiomes https://www.biorxiv.org/content/10.1101/2024.05.07.592803v1
Intraspecies warfare restricts strain coexistence in human skin microbiomes https://www.biorxiv.org/content/10.1101/2024.05.07.592803v1
Determining why only a fraction of encountered or applied bacterial strains engraft in a given perso
www.biorxiv.org
May 8, 2024 at 2:07 PM
Why don’t people who live together have the same strains of microbes? Tami Lieberman (@contaminatedsci.bsky.social) and I put forward one underexplored reason in our new preprint:
Intraspecies warfare restricts strain coexistence in human skin microbiomes
Intraspecies warfare restricts strain coexistence in human skin microbiomes
Reposted by David Helekal
My latest for JAMA. Dire headline but focuses on solutions - eg PCR test showing if patient responds to "older" antibiotic, modeling study suggesting how to deploy new drugs w/ national surveillance on shoestring budget.
@yhgrad.bsky.social @jenabbasi.bsky.social
jamanetwork.com/journals/jam...
@yhgrad.bsky.social @jenabbasi.bsky.social
jamanetwork.com/journals/jam...
“Super Gonorrhea” Has Arrived
This Medical News article discusses approaches to slow the spread of antimicrobial resistance in Neisseria gonorrhoeae.
jamanetwork.com
May 3, 2024 at 5:59 PM
My latest for JAMA. Dire headline but focuses on solutions - eg PCR test showing if patient responds to "older" antibiotic, modeling study suggesting how to deploy new drugs w/ national surveillance on shoestring budget.
@yhgrad.bsky.social @jenabbasi.bsky.social
jamanetwork.com/journals/jam...
@yhgrad.bsky.social @jenabbasi.bsky.social
jamanetwork.com/journals/jam...
Reposted by David Helekal
Fully automated assessment of correlated evolution on phylogenetic trees: now out in OA: doi.org/10.1111/2041... Thanks to all authors (not yet here). This explains the methodological basis of our recent work on epistatic interactions in the evolution of quinolone resistance: doi.org/10.1093/molb...
Evo‐Scope: Fully automated assessment of correlated evolution on phylogenetic trees
Correlated evolution describes how multiple biological traits evolve together. Recently developed methods provide increasingly detailed results of correlated evolution, sometimes at elevated compu...
doi.org
December 21, 2023 at 11:55 AM
Fully automated assessment of correlated evolution on phylogenetic trees: now out in OA: doi.org/10.1111/2041... Thanks to all authors (not yet here). This explains the methodological basis of our recent work on epistatic interactions in the evolution of quinolone resistance: doi.org/10.1093/molb...