Christophe Dessimoz
@dessimoz.bsky.social
Executive Director of SIB Swiss Institute of Bioinformatics @sib.swiss and Professor at the University of Lausanne (UNIL), Switzerland. @cdessimoz and @[email protected] elsewhere. Comparative Genomics, Phylogenetics, Evolution, Computational Biology.
And an EMBO meeting report led by Athina Gavriilidou entitled “Advances and challenges in understanding evolution through genome comparison.”
doi.org/10.1093/bioa...
doi.org/10.1093/bioa...
October 23, 2025 at 6:39 AM
And an EMBO meeting report led by Athina Gavriilidou entitled “Advances and challenges in understanding evolution through genome comparison.”
doi.org/10.1093/bioa...
doi.org/10.1093/bioa...
Correspondence in Nature: to make FAIR a reality, fund the data resources and expertise—not just data-management plans. A call to action co-signed with @francesarnold.bsky.social, Rich Roberts, and Tim Hubbard. doi.org/10.1038/d415...
October 23, 2025 at 6:26 AM
Correspondence in Nature: to make FAIR a reality, fund the data resources and expertise—not just data-management plans. A call to action co-signed with @francesarnold.bsky.social, Rich Roberts, and Tim Hubbard. doi.org/10.1038/d415...
Gene annotations matter for downstream analyses: different structural gene-annotation pipelines yield markedly different orthology calls. We compare four strategies across species and argue for standards & QC before inference. Work led by @silviaprietob.bsky.social. Paper: doi.org/10.1093/bioi...
October 23, 2025 at 6:20 AM
Gene annotations matter for downstream analyses: different structural gene-annotation pipelines yield markedly different orthology calls. We compare four strategies across species and argue for standards & QC before inference. Work led by @silviaprietob.bsky.social. Paper: doi.org/10.1093/bioi...
EdgeHOG reconstructs ancestral gene order at Tree-of-Life scale in linear time. 2,845 genomes → 1,133 ancestors. Vontigs for LECA (~1.8 Ga). Also dates gene adjacencies & rearrangements. Sexual chroms stand out! Led by Charles Bernard (research.pasteur.fr/fr/member/ch...) doi.org/10.1038/s415...
October 23, 2025 at 6:19 AM
EdgeHOG reconstructs ancestral gene order at Tree-of-Life scale in linear time. 2,845 genomes → 1,133 ancestors. Vontigs for LECA (~1.8 Ga). Also dates gene adjacencies & rearrangements. Sexual chroms stand out! Led by Charles Bernard (research.pasteur.fr/fr/member/ch...) doi.org/10.1038/s415...
Testing the "least-diverged ortholog” conjecture on >1M structs + expression across 16 animals & 20 plants, the LDO tends to retain ancestral function while the other copy specialises. Work led by @irenejulca.bsky.social. Paper: doi.org/10.1101/gr.2... Free preprint: www.biorxiv.org/content/10.1...
October 23, 2025 at 6:17 AM
Testing the "least-diverged ortholog” conjecture on >1M structs + expression across 16 animals & 20 plants, the LDO tends to retain ancestral function while the other copy specialises. Work led by @irenejulca.bsky.social. Paper: doi.org/10.1101/gr.2... Free preprint: www.biorxiv.org/content/10.1...
Structure-informed phylogenetic inference with FoldTree outperforms sequence-only trees on divergent proteins, and untangles RRNPPA quorum-sensing receptors across Gram-positive bacteria & phages. Work led by David Moi (www.linkedin.com/in/david-moi) Paper: doi.org/10.1038/s415...
October 23, 2025 at 6:13 AM
Structure-informed phylogenetic inference with FoldTree outperforms sequence-only trees on divergent proteins, and untangles RRNPPA quorum-sensing receptors across Gram-positive bacteria & phages. Work led by David Moi (www.linkedin.com/in/david-moi) Paper: doi.org/10.1038/s415...
Really important points by @alexbateman1.bsky.social on the importance of curation, addressing some of the myths out there.
Deeply resonates with the commentary Paul Thomas and I wrote last year www.nature.com/articles/s41...
Deeply resonates with the commentary Paul Thomas and I wrote last year www.nature.com/articles/s41...
July 24, 2025 at 8:13 AM
Really important points by @alexbateman1.bsky.social on the importance of curation, addressing some of the myths out there.
Deeply resonates with the commentary Paul Thomas and I wrote last year www.nature.com/articles/s41...
Deeply resonates with the commentary Paul Thomas and I wrote last year www.nature.com/articles/s41...
Fantastic keynote by @marcrr.bsky.social at the joint EvolCompGen-Function session of #ISMBECCB2025 on the power of (curated & FAIR) gene expression data from @bgee.org to study functional retention and innovation across animals, summarising 15+ yrs of work
Paper:
www.unil.ch/dee/en/home/...
Paper:
www.unil.ch/dee/en/home/...
July 22, 2025 at 10:54 AM
Fantastic keynote by @marcrr.bsky.social at the joint EvolCompGen-Function session of #ISMBECCB2025 on the power of (curated & FAIR) gene expression data from @bgee.org to study functional retention and innovation across animals, summarising 15+ yrs of work
Paper:
www.unil.ch/dee/en/home/...
Paper:
www.unil.ch/dee/en/home/...
🧬 Pandemics. AI. Digital sovereignty.
In life sciences, these are no longer separate topics – they are converging challenges that demand one thing above all: *trusted data infrastructure*.
The new SIB Profile 2025 is out. Thread!
In life sciences, these are no longer separate topics – they are converging challenges that demand one thing above all: *trusted data infrastructure*.
The new SIB Profile 2025 is out. Thread!
May 22, 2025 at 7:48 AM
🧬 Pandemics. AI. Digital sovereignty.
In life sciences, these are no longer separate topics – they are converging challenges that demand one thing above all: *trusted data infrastructure*.
The new SIB Profile 2025 is out. Thread!
In life sciences, these are no longer separate topics – they are converging challenges that demand one thing above all: *trusted data infrastructure*.
The new SIB Profile 2025 is out. Thread!
When the @sib.swiss Roadshow Initiative works out, everyone wins: optimized travel, more scientific exchange, and a chance to catch top speakers across Switzerland—this time with Prof. Piyanun Harnpicharnchai on fungal communities & water quality.
@saramitri.bsky.social @cbank.bsky.social
@saramitri.bsky.social @cbank.bsky.social
March 4, 2025 at 3:20 PM
When the @sib.swiss Roadshow Initiative works out, everyone wins: optimized travel, more scientific exchange, and a chance to catch top speakers across Switzerland—this time with Prof. Piyanun Harnpicharnchai on fungal communities & water quality.
@saramitri.bsky.social @cbank.bsky.social
@saramitri.bsky.social @cbank.bsky.social
SIB has stopped posting on X and joined BlueSky. Follow here @sib.swiss. We will continue posting on Mastodon mstdn.science/@SIB and LinkedIn too.
Quite a few SIB colleagues are already on BlueSky. Follow them here: go.bsky.app/TcDfZrs
Quite a few SIB colleagues are already on BlueSky. Follow them here: go.bsky.app/TcDfZrs
February 8, 2025 at 10:47 AM
SIB has stopped posting on X and joined BlueSky. Follow here @sib.swiss. We will continue posting on Mastodon mstdn.science/@SIB and LinkedIn too.
Quite a few SIB colleagues are already on BlueSky. Follow them here: go.bsky.app/TcDfZrs
Quite a few SIB colleagues are already on BlueSky. Follow them here: go.bsky.app/TcDfZrs
Our dear colleague @firefoxx66.bsky.social is indeed one to watch in 2025! 💯https://www.nature.com/immersive/d41586-024-03890-5/index.html
December 9, 2024 at 7:56 PM
Our dear colleague @firefoxx66.bsky.social is indeed one to watch in 2025! 💯https://www.nature.com/immersive/d41586-024-03890-5/index.html