@derianolab.bsky.social
🚨 Check out our latest article! 🚨
Spoiler: when NHEJ is out, polymerase theta steps in to fix persistent G1-phase breaks during the next S phase — not in mitosis! And for our fellow B cell fans, we explore how Pol θ contributes to immunoglobulin class switching.
@natcomms.nature.com
rdcu.be/eRTSe
Spoiler: when NHEJ is out, polymerase theta steps in to fix persistent G1-phase breaks during the next S phase — not in mitosis! And for our fellow B cell fans, we explore how Pol θ contributes to immunoglobulin class switching.
@natcomms.nature.com
rdcu.be/eRTSe
Polymerase theta repairs persistent G1-induced DNA breaks in S-phase during class switch recombination
Nature Communications - NHEJ is the primary repair pathway during class switch recombination. Here the authors show that in absence of NHEJ, Pol θ repairs persistent G1-induced breaks in...
rdcu.be
November 26, 2025 at 3:50 PM
🚨 Check out our latest article! 🚨
Spoiler: when NHEJ is out, polymerase theta steps in to fix persistent G1-phase breaks during the next S phase — not in mitosis! And for our fellow B cell fans, we explore how Pol θ contributes to immunoglobulin class switching.
@natcomms.nature.com
rdcu.be/eRTSe
Spoiler: when NHEJ is out, polymerase theta steps in to fix persistent G1-phase breaks during the next S phase — not in mitosis! And for our fellow B cell fans, we explore how Pol θ contributes to immunoglobulin class switching.
@natcomms.nature.com
rdcu.be/eRTSe
Our lab’s newest publication is now online! Senataxin promotes recombination fidelity during antigen receptor gene diversification | Science Signaling www.science.org/doi/10.1126/...
Senataxin promotes recombination fidelity during antigen receptor gene diversification
A CRISPR screen reveals a protective role for the RNA/DNA helicase senataxin during V(D)J recombination.
www.science.org
October 15, 2025 at 5:26 AM
Our lab’s newest publication is now online! Senataxin promotes recombination fidelity during antigen receptor gene diversification | Science Signaling www.science.org/doi/10.1126/...
Reposted
Plot twist: homologous recombination actually promotes the development of cancer!
This discussion has been started in the hope that it will be useful, see the link:
doi.org/10.1038/s413...
This discussion has been started in the hope that it will be useful, see the link:
doi.org/10.1038/s413...
RAD51-mediated homologous recombination is a pro-tumour driver pathway - Oncogene
Oncogene - RAD51-mediated homologous recombination is a pro-tumour driver pathway
doi.org
September 24, 2025 at 2:50 PM
Plot twist: homologous recombination actually promotes the development of cancer!
This discussion has been started in the hope that it will be useful, see the link:
doi.org/10.1038/s413...
This discussion has been started in the hope that it will be useful, see the link:
doi.org/10.1038/s413...
I am looking forward to my visit and to sharing some of our recent work with QBI colleagues!
We look forward to hosting Dr. Ludovic Deriano of Institut Pasteur @pasteur.fr next week at UCSF on August 5!
He’ll share how BRCA1/2-deficient cells adapt to DNA damage and how CRISPR screens reveal new targets for cancer therapy.
Learn more & save your spot: qbi.ucsf.edu/seminar-deri...
He’ll share how BRCA1/2-deficient cells adapt to DNA damage and how CRISPR screens reveal new targets for cancer therapy.
Learn more & save your spot: qbi.ucsf.edu/seminar-deri...
August 1, 2025 at 3:41 PM
I am looking forward to my visit and to sharing some of our recent work with QBI colleagues!
Reposted
The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability.
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1
Abstract. Genetic instability is a major hazard threatening the fate of cells and ultimately of organisms. DNA double-strand break (DSB) is a highly toxic
academic.oup.com
June 11, 2025 at 12:24 PM
The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability.
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
New publication from the lab. CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination - Lescale - 2025 - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....
CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination
Here we show that CST and SHLD are required for CSR, while SHLD1-CTC1 interaction via the SHLD1 LDLP motif is dispensable. Mechanistically, we show that CTC1 and SHLD1 are epistatic during CSR, preve...
onlinelibrary.wiley.com
April 3, 2025 at 7:24 PM
New publication from the lab. CST Is Epistatic With Shieldin to Limit DNA Double‐Strand Break End Resection and Promote Repair During Igh Class Switch Recombination - Lescale - 2025 - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/full/10....