DenisPBlondin
@denispblondin.bsky.social
Papa | Associate.Professor @USherbrooke 🇨🇦 | Researcher @_CRCHUS | Integrative Physiologist | Energy Metabolism in #Diabetes #Obesity
🙋Is this only limited to BAT though?
6️⃣ WAT lipolysis also did not respond in a graded fashion - it increased in the cold but the magnitude of the lipolytic response was not dependent on skin temperature.
7️⃣ This implies that another 🔥 mechanism, GL/FA cycling also ⬆️, but was not dose-dependent.
6️⃣ WAT lipolysis also did not respond in a graded fashion - it increased in the cold but the magnitude of the lipolytic response was not dependent on skin temperature.
7️⃣ This implies that another 🔥 mechanism, GL/FA cycling also ⬆️, but was not dose-dependent.
July 16, 2025 at 4:09 PM
🙋Is this only limited to BAT though?
6️⃣ WAT lipolysis also did not respond in a graded fashion - it increased in the cold but the magnitude of the lipolytic response was not dependent on skin temperature.
7️⃣ This implies that another 🔥 mechanism, GL/FA cycling also ⬆️, but was not dose-dependent.
6️⃣ WAT lipolysis also did not respond in a graded fashion - it increased in the cold but the magnitude of the lipolytic response was not dependent on skin temperature.
7️⃣ This implies that another 🔥 mechanism, GL/FA cycling also ⬆️, but was not dose-dependent.
🙋What about BAT, what about BAT!
5️⃣Importantly, BAT perfusion and oxidative metabolism increased in the cold, but did not increase as a function of skin temperature.
In other words, with a minimal stress to activate BAT, 🔥 is either on or off - there is not a graded response!
5️⃣Importantly, BAT perfusion and oxidative metabolism increased in the cold, but did not increase as a function of skin temperature.
In other words, with a minimal stress to activate BAT, 🔥 is either on or off - there is not a graded response!
July 16, 2025 at 4:09 PM
🙋What about BAT, what about BAT!
5️⃣Importantly, BAT perfusion and oxidative metabolism increased in the cold, but did not increase as a function of skin temperature.
In other words, with a minimal stress to activate BAT, 🔥 is either on or off - there is not a graded response!
5️⃣Importantly, BAT perfusion and oxidative metabolism increased in the cold, but did not increase as a function of skin temperature.
In other words, with a minimal stress to activate BAT, 🔥 is either on or off - there is not a graded response!
🙋Yes, but how does this impact myocardial 💖 metabolism?
4️⃣The perfusion and oxidative metabolism of the myocardium, determined by 11C-acetate PET, only increased at the colder skin temperature and primarily in women.
This represents the first measurement of 💖 metabolism in cold-exposed humans.
4️⃣The perfusion and oxidative metabolism of the myocardium, determined by 11C-acetate PET, only increased at the colder skin temperature and primarily in women.
This represents the first measurement of 💖 metabolism in cold-exposed humans.
July 16, 2025 at 4:09 PM
🙋Yes, but how does this impact myocardial 💖 metabolism?
4️⃣The perfusion and oxidative metabolism of the myocardium, determined by 11C-acetate PET, only increased at the colder skin temperature and primarily in women.
This represents the first measurement of 💖 metabolism in cold-exposed humans.
4️⃣The perfusion and oxidative metabolism of the myocardium, determined by 11C-acetate PET, only increased at the colder skin temperature and primarily in women.
This represents the first measurement of 💖 metabolism in cold-exposed humans.
🙋 What about shivering?
3️⃣ Shivering intensity ⬆️ as function of skin cooling, with women shivering to a greater extent than men for the same skin temperature.
Women appeared to recruit a greater #️⃣ of motor units than men, reflected by the ⬆️ in both intensity of continuous and burst shivering.
3️⃣ Shivering intensity ⬆️ as function of skin cooling, with women shivering to a greater extent than men for the same skin temperature.
Women appeared to recruit a greater #️⃣ of motor units than men, reflected by the ⬆️ in both intensity of continuous and burst shivering.
July 16, 2025 at 4:09 PM
🙋 What about shivering?
3️⃣ Shivering intensity ⬆️ as function of skin cooling, with women shivering to a greater extent than men for the same skin temperature.
Women appeared to recruit a greater #️⃣ of motor units than men, reflected by the ⬆️ in both intensity of continuous and burst shivering.
3️⃣ Shivering intensity ⬆️ as function of skin cooling, with women shivering to a greater extent than men for the same skin temperature.
Women appeared to recruit a greater #️⃣ of motor units than men, reflected by the ⬆️ in both intensity of continuous and burst shivering.
1️⃣ Heat production 🔥 increased as a function of mean skin temperature, in both men and women.
2️⃣ ♂️♀️ differences in 🔥 are driven by differences in body mass. The cold-induced increase in 🔥 did not differ between the sexes.
2️⃣ ♂️♀️ differences in 🔥 are driven by differences in body mass. The cold-induced increase in 🔥 did not differ between the sexes.
July 16, 2025 at 4:09 PM
1️⃣ Heat production 🔥 increased as a function of mean skin temperature, in both men and women.
2️⃣ ♂️♀️ differences in 🔥 are driven by differences in body mass. The cold-induced increase in 🔥 did not differ between the sexes.
2️⃣ ♂️♀️ differences in 🔥 are driven by differences in body mass. The cold-induced increase in 🔥 did not differ between the sexes.
We were then interested in understanding how different organs respond to different cold stimulations, particularly adipose tissue (brown and white adipose tissue).
So we took advantage of our closed-loop temp control system to clamp the mean skin temp of our participants to either 30°C or 26°C.
So we took advantage of our closed-loop temp control system to clamp the mean skin temp of our participants to either 30°C or 26°C.
![14 Participants were exposed to a cold stimulus eliciting a mean skin temperature of 30 or 26°C. They underwent PET imaging with [11C]-acetate and FDG to examine organ-specific metabolism in response to the cold.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cbz2ifnjiyyxol5exbt2lq4w/bafkreicrorv4fbeevcx3tqtzxff6r6o7sxxjrox6xcxsufamknm5qwwvnq@jpeg)
July 16, 2025 at 4:09 PM
We were then interested in understanding how different organs respond to different cold stimulations, particularly adipose tissue (brown and white adipose tissue).
So we took advantage of our closed-loop temp control system to clamp the mean skin temp of our participants to either 30°C or 26°C.
So we took advantage of our closed-loop temp control system to clamp the mean skin temp of our participants to either 30°C or 26°C.
✅Love cold exposure❄️, heat exposure🔥, or exercise physiology🚴?
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!
November 13, 2024 at 11:51 PM
✅Love cold exposure❄️, heat exposure🔥, or exercise physiology🚴?
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!
✅Looking to do an MSc/PhD/Postdoc🔬?
✅Interested in learning how to perform PET imaging, high-resolution respirometry, stable isotope methods or indirect calorimetry?
Come join us in Sherbrooke, Canada 🇨🇦!