Davis McCarthy
@davisjmcc.bsky.social
Head, Bioinformatics and Cellular Genomics Lab,
St Vincent's Institute of Medical Research, Melbourne. Stats, AI/ML, bioinformatics, genomics, single-cell.
https://www.svi.edu.au/researchers/dr-davis-mccarthy/
St Vincent's Institute of Medical Research, Melbourne. Stats, AI/ML, bioinformatics, genomics, single-cell.
https://www.svi.edu.au/researchers/dr-davis-mccarthy/
i can only imagine the licensing agreement needed to get that name over the line
September 16, 2025 at 1:10 AM
i can only imagine the licensing agreement needed to get that name over the line
expertise, maybe...energy, ah that's a different issue...
September 10, 2025 at 12:41 AM
expertise, maybe...energy, ah that's a different issue...
Gosh the number of times I see people testing differentially expressed genes and then applying a post-hoc fold-change threshold and I have to scream into the void WE WROTE A METHOD TO TEST THE INTERVAL NULL (...15+ years ago 🫠)
July 23, 2025 at 4:51 AM
Gosh the number of times I see people testing differentially expressed genes and then applying a post-hoc fold-change threshold and I have to scream into the void WE WROTE A METHOD TO TEST THE INTERVAL NULL (...15+ years ago 🫠)
Increasingly, I think one of the most important questions people need to ask (and answer) themselves is "How much is enough?"
June 25, 2025 at 1:05 AM
Increasingly, I think one of the most important questions people need to ask (and answer) themselves is "How much is enough?"
I would also very much like a mixed model in edgeR 😉
afaik (given I haven't been an active developer for years), it hasn't been possible to implement a mixed model in a way that's compatible with the empirical Bayes information sharing...and for edgeR eBayes is more important if there's a tradeoff
afaik (given I haven't been an active developer for years), it hasn't been possible to implement a mixed model in a way that's compatible with the empirical Bayes information sharing...and for edgeR eBayes is more important if there's a tradeoff
June 20, 2025 at 12:11 AM
I would also very much like a mixed model in edgeR 😉
afaik (given I haven't been an active developer for years), it hasn't been possible to implement a mixed model in a way that's compatible with the empirical Bayes information sharing...and for edgeR eBayes is more important if there's a tradeoff
afaik (given I haven't been an active developer for years), it hasn't been possible to implement a mixed model in a way that's compatible with the empirical Bayes information sharing...and for edgeR eBayes is more important if there's a tradeoff