David A. Sinclair, Ph.D.
@davidsinclairphd.bsky.social
Professor @Harvard researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own 🙏✌️
Patent granted!
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
November 26, 2025 at 8:58 PM
Patent granted!
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“
Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu
RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏
November 8, 2025 at 7:06 PM
RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏
Dr. Haghighi is Chief Executive and Director, Harvard Medical School International Center for Genetic Disease, Principal Investigator and Director, Bahrain National Genome Program at Harvard and Assistant Professor of Medicine, Harvard Medical School, and Brigham and Women's Hospital
October 15, 2025 at 11:30 PM
Dr. Haghighi is Chief Executive and Director, Harvard Medical School International Center for Genetic Disease, Principal Investigator and Director, Bahrain National Genome Program at Harvard and Assistant Professor of Medicine, Harvard Medical School, and Brigham and Women's Hospital
This is more than a regional milestone. It reflects our broader commitment to working with governments, academia, and industry worldwide to responsibly unlock the full potential of genomics and AI
October 15, 2025 at 11:30 PM
This is more than a regional milestone. It reflects our broader commitment to working with governments, academia, and industry worldwide to responsibly unlock the full potential of genomics and AI
Dr. Alireza Haghighi, my cofounder and I, are proud to announce an exciting partnership with Asia University to develop a "Sovereign AI Life Science Data Platform for Taiwan", a national system for secure health data sharing, AI-powered analytics, and collaborative research
October 15, 2025 at 11:30 PM
Dr. Alireza Haghighi, my cofounder and I, are proud to announce an exciting partnership with Asia University to develop a "Sovereign AI Life Science Data Platform for Taiwan", a national system for secure health data sharing, AI-powered analytics, and collaborative research
With ER-100 on track for human trials in Q1 2026, this program is moving quickly 💉👁️ Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board & entire R&D team led by Dr. Sharon Rosenzweig-Lipson
August 26, 2025 at 7:12 PM
With ER-100 on track for human trials in Q1 2026, this program is moving quickly 💉👁️ Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board & entire R&D team led by Dr. Sharon Rosenzweig-Lipson
In liver disease (MASH), ER-300, an AAV-delivered package of reprogramming genes, improved multiple key liver health biomarkers in an animal model, from ALT/AST to cholesterol and steatosis (fat content) scores
August 26, 2025 at 7:12 PM
In liver disease (MASH), ER-300, an AAV-delivered package of reprogramming genes, improved multiple key liver health biomarkers in an animal model, from ALT/AST to cholesterol and steatosis (fat content) scores
This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea
August 26, 2025 at 7:12 PM
This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea
All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊
May 16, 2025 at 1:17 AM
All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊
Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
May 6, 2025 at 5:50 PM
Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz
Link to the review: link.springer.com/article/10.1...
March 24, 2025 at 9:06 PM
Link to the review: link.springer.com/article/10.1...
Where to get polyphenols? From berries, apples with skin, cherries, plums, pomegranates, spinach, red onions, artichokes, broccoli, asparagus, matcha green tea, black tea, coffee, dark chocolate, turmeric, beans, EVOO and any deeply-colored vegetable
March 24, 2025 at 9:06 PM
Where to get polyphenols? From berries, apples with skin, cherries, plums, pomegranates, spinach, red onions, artichokes, broccoli, asparagus, matcha green tea, black tea, coffee, dark chocolate, turmeric, beans, EVOO and any deeply-colored vegetable
The authors of this new review discuss how polyphenols like curcumin, quercetin, resveratrol, and genistein seems to also target cancer-related miRNAs, thereby slowing cancer progression...
March 24, 2025 at 9:06 PM
The authors of this new review discuss how polyphenols like curcumin, quercetin, resveratrol, and genistein seems to also target cancer-related miRNAs, thereby slowing cancer progression...
In the 1990s, Victor Ambros and Gary Ruvkun (in my Department @harvardmed.bsky.social) were interested in how different cell types develop in worms. They discovered microRNA, a new class of tiny RNA molecules that regulate genes called miRNAs...
March 24, 2025 at 9:06 PM
In the 1990s, Victor Ambros and Gary Ruvkun (in my Department @harvardmed.bsky.social) were interested in how different cell types develop in worms. They discovered microRNA, a new class of tiny RNA molecules that regulate genes called miRNAs...
In the 1990's, antioxidants were all the rage. Today, we know so much more, while the food and beverage industry still promotes antioxidants as though they were the most important thing...
March 24, 2025 at 9:06 PM
In the 1990's, antioxidants were all the rage. Today, we know so much more, while the food and beverage industry still promotes antioxidants as though they were the most important thing...
Polyphenols aren't just antioxidants. They signal to the body ➡️ defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs...a thread 🧵
March 24, 2025 at 9:06 PM
Polyphenols aren't just antioxidants. They signal to the body ➡️ defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs...a thread 🧵
Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏
t.co/XGexiZFQg3
t.co/XGexiZFQg3
February 4, 2025 at 5:13 PM
Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏
t.co/XGexiZFQg3
t.co/XGexiZFQg3
I couldn’t be prouder of the Sinclair lab family, now over 200 amazing people 🥹
February 3, 2025 at 11:04 PM
I couldn’t be prouder of the Sinclair lab family, now over 200 amazing people 🥹
Haim showed that the human SIRT1 gene is activated by CR, which protects cells (Science), Dudley showed all yeast Sirtuins mediate CR (Science) & Joe showed activators improve 🐁 health (Nature)
February 3, 2025 at 11:04 PM
Haim showed that the human SIRT1 gene is activated by CR, which protects cells (Science), Dudley showed all yeast Sirtuins mediate CR (Science) & Joe showed activators improve 🐁 health (Nature)
Roz showed adversity turns on NAD biosynthetic gene to extend lifespan (Nature), Kevin & Jason showed Sirtuins can be activated by molecules (Nature & Science)…
February 3, 2025 at 11:04 PM
Roz showed adversity turns on NAD biosynthetic gene to extend lifespan (Nature), Kevin & Jason showed Sirtuins can be activated by molecules (Nature & Science)…
In the first 5 years, Kevin & Roz showed Sirtuins are regulated by B3 and NAD availability (in Science)…
February 3, 2025 at 11:04 PM
In the first 5 years, Kevin & Roz showed Sirtuins are regulated by B3 and NAD availability (in Science)…
but we didn’t know how epigenetics was related to aging, why the epigenome changed over time, if aging was reversible, how the environment influenced Sirtuin activity, or if any of this was relevant to humans
February 3, 2025 at 11:04 PM
but we didn’t know how epigenetics was related to aging, why the epigenome changed over time, if aging was reversible, how the environment influenced Sirtuin activity, or if any of this was relevant to humans
In those days, we barely knew anything about aging. The Sirtuins had just been linked to yeast aging (in the Guarente lab @mit where I’d moved from)…
February 3, 2025 at 11:04 PM
In those days, we barely knew anything about aging. The Sirtuins had just been linked to yeast aging (in the Guarente lab @mit where I’d moved from)…
Exciting times, stressful times
February 3, 2025 at 11:04 PM
Exciting times, stressful times