David Rufino-Ramos
@davidrufinoramos.bsky.social
PostDoc @BKleinstiverLab at MGH | HMS
Alumni @LalmeidaLab & Xandra Breakefield'sLab
Genome Editing | Protein Evolution | EVs | Gene Therapy 🧬
Alumni @LalmeidaLab & Xandra Breakefield'sLab
Genome Editing | Protein Evolution | EVs | Gene Therapy 🧬
Reposted by David Rufino-Ramos
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reprogramming site-specific retrotransposon activity to new DNA sites - Nature
A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large pa...
www.nature.com
April 9, 2025 at 5:10 PM
So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵
www.nature.com/articles/s41...
www.nature.com/articles/s41...