David Jones
@davidjonesbrain.bsky.social
Behavioral neurologist and AI director working to end degeneration of mental function and use technology to transform the practice of neurology.
Neuro AI Program (NAIP)
https://naip.mayo.edu
https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg
Neuro AI Program (NAIP)
https://naip.mayo.edu
https://www.youtube.com/channel/UCj9q9jnuNZNNZnx48-P1vkg
Focusing on AD only, out of context of all degenerative disease of intelligence is one of the major errors IMO. Intelligence is energetically expensive and FDG-PET provides a landscape for all dementias, and connects to the clinic to computational neuroscience: bsky.app/profile/davi...
1/
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
Every week in my neurology clinic, I see people lost in the search for a diagnosis.
Sometimes, what’s causing their dementia symptoms is treatable — but was missed for years.
We just published a new AI tool to change that. Here's why it matters🧵
@mayoclinic.org
#ENDAlz
July 3, 2025 at 7:20 PM
Focusing on AD only, out of context of all degenerative disease of intelligence is one of the major errors IMO. Intelligence is energetically expensive and FDG-PET provides a landscape for all dementias, and connects to the clinic to computational neuroscience: bsky.app/profile/davi...
18/
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org
June 29, 2025 at 5:11 PM
18/
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org
If we want to catch reversible cases, personalize care, and speed up new treatments — we need smarter tools.
Tools that understand dementia with nuance.
We built one. And it’s working.
🧠🔍
#Endalz #NeuroAI #HealthTech #FutureOfCare
@mayoclinic.org
17/
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
June 29, 2025 at 5:11 PM
17/
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
It is grounded in the Global Functional State Space (GFSS) — a neuroscience-informed model of brain function and dysfunction.That is why we call it StateViewer.It connects clinical care to systems neuroscience, paving the way for new science and new cures. #NeuroAI www.nature.com/articles/s41...
16/
StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech
StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech
June 29, 2025 at 5:11 PM
16/
StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech
StateViewer isn’t just a model.
It’s part of a shift:
🧠 From opaque to interpretable
🧠 From limited access to scalable tools
🧠 From "maybe it’s dementia" to "here’s what kind and what’s next"
Clinical AI built by neurologists, for patients.
#NeuroTech
15/
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI
June 29, 2025 at 5:11 PM
15/
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI
From our
@GreenJournal
paper (July 2025):
📈 Sensitivity = 0.89
📊 AUROC = 0.93
✅ 9 syndromes detected
📉 Reader errors reduced 3.3×
🔬 External validation in ADNI
🧠 Interpretable and scalable
#Neurology #AI
14/
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials
June 29, 2025 at 5:11 PM
14/
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials
This also matters for clinical trials.
🧬 Disease mechanisms don’t map 1:1 to syndromes
🎯 Precision targeting requires deeper models
⚡️ Cleaner cohorts = faster progress
StateViewer captures this complexity and makes it actionable.
#Alzheimers #ClinicalTrials
13/
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI
June 29, 2025 at 5:11 PM
13/
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI
It’s been trained on 3,600+ real patient cases.
Externally validated in the ADNI dataset.
And it doesn’t just give answers — it explains them.
It shows how a new case relates to past ones.
Transparent, interpretable, clinical-grade AI.
#ExplainableAI
12/
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare
June 29, 2025 at 5:11 PM
12/
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare
In a blinded study, clinicians using StateViewer were 3.3× more likely to make the correct diagnosis than those using today’s standard tools.
Even the most experienced doctors improved with it.
#DigitalNeurology #AIinHealthcare
11/
Here’s what makes StateViewer different:
✅ Needs only 1 input: a brain FDG-PET scan
✅Returns multiple diagnoses with statistics
✅Visual maps to explain “why”
✅Supports (not replaces) the physician
It’s made for real-world use and it’s already used in the real-world.
Here’s what makes StateViewer different:
✅ Needs only 1 input: a brain FDG-PET scan
✅Returns multiple diagnoses with statistics
✅Visual maps to explain “why”
✅Supports (not replaces) the physician
It’s made for real-world use and it’s already used in the real-world.
June 29, 2025 at 5:11 PM
11/
Here’s what makes StateViewer different:
✅ Needs only 1 input: a brain FDG-PET scan
✅Returns multiple diagnoses with statistics
✅Visual maps to explain “why”
✅Supports (not replaces) the physician
It’s made for real-world use and it’s already used in the real-world.
Here’s what makes StateViewer different:
✅ Needs only 1 input: a brain FDG-PET scan
✅Returns multiple diagnoses with statistics
✅Visual maps to explain “why”
✅Supports (not replaces) the physician
It’s made for real-world use and it’s already used in the real-world.
10/
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech
June 29, 2025 at 5:11 PM
10/
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech
It’s called StateViewer.
A clinical AI tool that reads brain FDG-PET scans and recognizes patterns of 14 different dementia syndromes — like a specialist would. (only nine were published)
But it’s built to augment, not replace, the clinician.
#CDSS #NeuroAI #DementiaTech
9/
That’s why we’re building scalable solutions.
So that even where no specialist is present, expertise is.
Inside Mayo Clinic, we built a platform to bring precision diagnosis anywhere.
👉 siliconangle.com/2025/04/16/i...
#AI
That’s why we’re building scalable solutions.
So that even where no specialist is present, expertise is.
Inside Mayo Clinic, we built a platform to bring precision diagnosis anywhere.
👉 siliconangle.com/2025/04/16/i...
#AI
AI diagnostics improve neurological care - SiliconANGLE
AI diagnostics accelerate brain scan analysis, helping clinicians close the expertise gap and deliver faster, accurate neurological care.
siliconangle.com
June 29, 2025 at 5:11 PM
9/
That’s why we’re building scalable solutions.
So that even where no specialist is present, expertise is.
Inside Mayo Clinic, we built a platform to bring precision diagnosis anywhere.
👉 siliconangle.com/2025/04/16/i...
#AI
That’s why we’re building scalable solutions.
So that even where no specialist is present, expertise is.
Inside Mayo Clinic, we built a platform to bring precision diagnosis anywhere.
👉 siliconangle.com/2025/04/16/i...
#AI