David Castillo-Azofeifa
@davidc-a.bsky.social
Principal Scientist/Group Leader @genentech, interested in the diverse regenerative strategies of tissues and how they fail later in life. From CR 🇨🇷
https://www.gene.com/scientists/our-scientists/david-castillo-azofeifa
https://www.gene.com/scientists/our-scientists/david-castillo-azofeifa
Our new preprint: doi.org/10.1101/2025...
IFNγ is a double-edged sword for gut regeneration. Young guts: transient burst heals. Aged guts: prolonged upregulation impairs repair by trapping cells in a fetal-like state🔥📉 #immunology #inflammaging #aging #stemcells #regeneration
IFNγ is a double-edged sword for gut regeneration. Young guts: transient burst heals. Aged guts: prolonged upregulation impairs repair by trapping cells in a fetal-like state🔥📉 #immunology #inflammaging #aging #stemcells #regeneration
Maladaptive inflammatory signaling in old mice impairs colonic regeneration by promoting a sustained fetal-like epithelial state
Aging is associated with a decline in the regenerative capacity of many tissues. Central to this decline is a complex interplay between inflammation and stem cell function. How these two processes are...
doi.org
July 23, 2025 at 8:57 PM
Our new preprint: doi.org/10.1101/2025...
IFNγ is a double-edged sword for gut regeneration. Young guts: transient burst heals. Aged guts: prolonged upregulation impairs repair by trapping cells in a fetal-like state🔥📉 #immunology #inflammaging #aging #stemcells #regeneration
IFNγ is a double-edged sword for gut regeneration. Young guts: transient burst heals. Aged guts: prolonged upregulation impairs repair by trapping cells in a fetal-like state🔥📉 #immunology #inflammaging #aging #stemcells #regeneration