David A. Markowitz
davidamarkowitz.bsky.social
David A. Markowitz
@davidamarkowitz.bsky.social
We still need a massive improvement in compute efficiency of binder design tools to make this a financially compelling alternative to CROs for the average user.
November 25, 2025 at 3:54 PM
Furthermore, the above cost of binder design in the cloud doesn't include the cost of experimental validation of your candidates, which would be needed to achieve the same results as a CRO. Might be another few K in labor and materials, plus time needed to make the thing.
November 25, 2025 at 3:54 PM
Maybe it's specific to AI tools? As a comp, this non-AI announcement + blog post from last year did much larger numbers on Bluesky, well before the paper was released. People were happy to like and share: bsky.app/profile/andr...
🧪 E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (🧠→🔬→💻). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains.

Read more: e11.bio/news/roadmap
November 17, 2025 at 2:48 PM
Haven't seen Carlos in forever, but reading this gleeful post in his voice made my morning. Super cool work
November 17, 2025 at 2:14 PM
As this widely reported genocide plays out in real time and Arab nations express growing horror, it's sad to see the continued apathy toward it in the West. Silence on both left and right wing social media. No demonstrations, no boycotts... www.aljazeera.com/news/2025/10...
‘A true genocide’: RSF kills ‘at least 1,500 people’ in Sudan’s el-Fasher
Saudi Arabia, Egypt, Turkiye, Jordan and Qatar express alarm as more evidence emerges of mass killings by paramilitary forces in Sudan's in el-Fasher.
www.aljazeera.com
October 30, 2025 at 1:53 AM
In @nytopinion.nytimes.com

“There is bipartisan agreement in the United States that Sudan is suffering both genocide and famine — and also, apparently, a bipartisan consensus to do little about it,” our columnist @nickkristof.bsky.social writes.
Opinion | In Sudan, No One Doubts That This Is Genocide
Both the Biden and Trump administrations have described Sudan as suffering genocide. And no one’s done much about it.
nyti.ms
September 1, 2025 at 9:21 PM
Update From Doctors Without Borders: "This is one of the worst situations I have seen” ... "It really is quite unique in terms of the volume of affected people, the level of suffering and also the underfunding of the international response” www.ft.com/content/d331...
‘We watch the graveyards from space’: satellites track Sudanese city under siege
Paramilitary forces have cut off El Fasher, the military government’s final stronghold in the western Darfur region
www.ft.com
September 1, 2025 at 7:53 PM
Wow, VERY interested to see this paper!
August 21, 2025 at 3:07 PM
The latest on this humanitarian catastrophe, one of several happening in the world right now, yet strangely neglected in the public discourse: www.theglobeandmail.com/world/articl...
Starvation spreading in Sudan as aid convoys blocked by siege, UN says
Situation is worsening in El Fasher, which is enduring a daily bombardment of artillery shelling and drone attacks by RSF fighters
www.theglobeandmail.com
August 6, 2025 at 4:19 PM